巻号一覧
50 巻, 6 号
選択された号の論文の4件中1～4を表示しています
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徳永 徹, 片岡 哲朗, 山本 三郎, 室橋 豊穂1975 年 50 巻 6 号 p. 147-152
発行日: 1975/06/15
公開日: 2011/05/24
ジャーナル フリーSocial needs for a single dose preparation of purified protein derivative (PPD) have been increasing year by year in the fields of surveillance for tuberculosis and of cancer immunotherapy. For the purpose of meeting these requests, the authors examined a new type of PPD preparation that was developed recently by the Japan BCG Laboratory and named “PPD Disposable (one dose)”.
Potency test was carried out in sensitized guinea pigs and human subjects according to the method described in the Minimum Requirement of Biological Products published by the Ministry of Health and Welfare, Japanese Government in 1973. As shown in Tables 1 and 2 in the text, difference in the potency between the test PPD and the standard PPD was statistically insignificant (p=0.01) in both animal and human subjects.
The potencies of 10 lots of the PPD preparations were examined in sensitized guinea pigs comparing with the standard PPD. As shown in Table 3, the difference among them was not significant from each other with p=0.01. Quantitative analysis on the amount of lactose distributed into the each preparation and lyophilized and on the moisture content of the final products were performed. No significant difference among the values obtained was found.
At 30 and 60 minutes after dissolving the test PPD, potency test was carried out by using sensitized guinea pigs. The results obtained are shown in Table 4, indicating that the decline of the potency was not significant even 60 minutes after the dissolving.
When the procedures of sucking up the buffer solution to dissolve the test PPD were incorrectly or carelessly carried out, the skin reaction sizes reduced than those elicited by the standard PPD.
The aluminum foils sealed hermetically the single dose PPD preparations were intension ally broken and the PPD preparations that became wet within 2 days by absorbing atomospheric moisture were picked up, and potency test of these preparations were carried out by using guinea pigs, and no significant decline of the potency was demonstrated.
The single dose PPD preparation can be used con veniently and effectively in the daily practice, provided that the directions for use are kept correctly.抄録全体を表示PDF形式でダウンロード (1557K) -
―初感染巣,再感染巣における活性化マクロファージと14C標識BCGとの相互関係について―安藤 正幸, 志摩 清, 徳臣 晴比古1975 年 50 巻 6 号 p. 153-160
発行日: 1975/06/15
公開日: 2011/05/24
ジャーナル フリーTo evaluate immunopathologically the defense mechanism against tuberculosis infection in the immune host, the interrelation between activated macrophages (MN) and 14C-labeled BCG was observed in BCG lesions. In normal and tuberculin-positive rabbits, multiple dermal BCG lesions were produced and biopsied at 3, 7, 10, 14 and 21 days after inoculation. A different lesion was used for each biopsy. The biopsies were quickly frozen and cut in a cryostat. The resulting tissue sections were stained for the lysosomal enzyme, β-galactosidase, which reflects the state of MN activation. Tubercle bacilli in the lesions were recognized both by staining with carbolfuchsin and by radioautography. The 14C-label was of great help in detecting the bacilli and showing progressive digestion of them.抄録全体を表示PDF形式でダウンロード (4104K) -
結核療法研究協議会1975 年 50 巻 6 号 p. 161-167
発行日: 1975/06/15
公開日: 2011/05/24
ジャーナル フリーSide effects of antituberculous drugs among pulmonary tuberculosis patients with positive bacilli who were admitted to 50 hospitals or sanatoria during the period from January 1st to June 30th, 1972, were investigated. Two hundred thirty one patients of original treatment and 315 patients of retreatment were subjected to this study.
The triple combination of streptomyc in, isoniazid and PAS was used in 70.1 % of the original treatment cases, and 54 cases were treated with regimens containing second line drugs from the beginning. In retreatment cases, the triple combination of streptomycin, isoniazid and PAS was used in only 24.4% and second line drugs were used so widely from the start of retreatment that the total number of regimens amounted to 57.
Nearly half of patients who were treated with streptomycin were received daily injection for one to 3 months. No patients discontinued streptomycin due to side effects on 8th cervical nerve except one patient (1.3%) in streptomycin intermittently injected group, while streptomycin was discontinued due to the side effect in 4 cases (6.3%) in streptomycin daily group.
In original treatment patients, side effects occured more frequently in ligh t weight patients than heavy patients. The difference, however, was not statistically significance, and no difference was seen in retreatment cases according to weight. The incidence of allergic reactions such as fever or rash was higher in original treatment cases than in retreatment cases. Gastrointestinal disturbance, rise of GOTand GPT, allergic reactions and tinnitus were the side effects which were frequently observed and most of them appeared within 3 months after starting chemotherapy.
Isoniazid was discontinued in two cases out of 449 patients who were treated with the regimens containning isoniazid. The incidence of drop-out cases due to side effects was low in isoniazid, rifampicin and ethambutol, and it was 0.4%, 1.3% and 2.6%, respectively.抄録全体を表示PDF形式でダウンロード (1828K) -
武田 操1975 年 50 巻 6 号 p. 169-180
発行日: 1975/06/15
公開日: 2011/05/24
ジャーナル フリーThe actual status of primary tuberculosis cases registered at 17 health centres in Tokyo was investigated. Out of cases applying the subsidy for treatment expense of tuberculosis during the period from January 1950 to December 1972 to the above health centres, 179 cases with the diagnosis of primary tuberculosis were subjected to this study. These cases include all cases with the diagnosis of primary infection tuberculosis, hilar lymphnodes tuberculosis, pleurisy, and tuberculin positive conversion due to natural infection and cases with the diagnosis of pulmonary tuberculosis, cervical glandular tuberculosis and tuberculous meningitis who were applied the subsidy for treatment expense for the first time and were assumed to be within 3 years after primary infection. The subjects consisted of 95 male and 84 female, and approximately two thirds were less than 5 years of age.抄録全体を表示PDF形式でダウンロード (2400K)
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