巻号一覧
52 巻, 7 号
選択された号の論文の6件中1～6を表示しています
- |<
- <
- 1
- >
- >|
-
束村 道雄1977 年 52 巻 7 号 p. 319-325
発行日: 1977/07/15
公開日: 2011/05/24
ジャーナル フリーThe distribution of species of mycobacteria other than tubercle bacilli which cause lung disease and those isolated from sputum specimens, including the strains that cause disease and casual isolates, are different in various countries and in different area in the same countries. In Japan, the disease occur more frequently in the Pacific ocean coast (South coast) of the Honshu island and relatively rare in North Japan. Disease due to M. kansasii occurs frequently in the Tokyo area. Geographic difference in the occurrence of the disease is reported also in the United States of America, Australia and West Germany.
The difference in the species of the mycobacteria that cause the disease and those isolated from sputa is considered to be related to the geographical difference of the ecology of mycobac teria.
Generally speaking, disease due to M. kansasii occupies more than one half of the disease due to all mycobacteria other than tubercle bacilli in the United States of America and in Europe. In contrast to the above, disease due to M. intracellulare occupies 75 to 90% of the disease, and the disease due to M. kansasii remains at the level of a few per cent in Japan and Australia.
Moreover, disease due to M. xenopi occurs in the former areas, whereas the disease has not been seen up to now in the latter areas.
In the United States, the proportion of the strains that show Avium serotype is 25% among the M. aviurnintracellulare strains that caused lung disease, whereas the rate remains only a few per cent in Japan.
Difference in some biological characteristics are also observed between the strains isolated in Japan and the strains isolated in Rhodesia. The majority of the Japan isolates grow at 45°C, whereas the majority of the Rhodesian isolates do not grow at this temperature.抄録全体を表示PDF形式でダウンロード (885K) -
M.M. ABDEL KADER, K.M. SOLIMAN, S. SHOUAB, B.A. EL-MOURSI1977 年 52 巻 7 号 p. 327-329
発行日: 1977/07/15
公開日: 2011/05/24
ジャーナル フリーIt was shown by Abdel Kader and Zaki that histidine (in vitro), tryptophan and some of its meta bolites (both in vitro and in vivo) possessed bacteriostatic effect on mycobacterium tuberculosis. Histidine is now gaining a site in researches done on human tuberculosis. Kulyabko found increased histamine level in blood in acute primary tuberculosis in young children. This investigation was, therefore, conducted to study the effect of histidine on tuberculosis in guinea pigs.抄録全体を表示PDF形式でダウンロード (285K) -
III. Mycobacterium intracellulareに対する抗結核剤の併用効果について久世 文幸, 武田 貞夫, 前川 暢夫1977 年 52 巻 7 号 p. 331-338
発行日: 1977/07/15
公開日: 2011/05/24
ジャーナル フリーThe sensitivities of 20 disease associated strains of Mycobacterium intracellulare were tested in vitro using Tween Albumin liquid medium to various triple-drug combinations. The triple drug regimens tested were SM·PAS·INH, SM·INH·EB, KM·INH·EB, KM·TH·CS, RFP·EEB·INH, RFP·INH·CS, KM·EB·RFP and VM·ERFP·TH, all of which were considered as poten tially usable in the treatment of Atypical Mycobacterial Diseases.
The ratio of combination in these triple-drup regimens in this study was uniformly 1: 1: 1 in microgram. Hundred micrograms per milliliter of each drug was included in the first test tube, which was then successively doubly diluted until the 19th tube. The twentieth tube was used as a control. As the same time, single drug regimens were tested for the comparisons.
As a whole, all these triple-drug combinations showed more or less advantages upon the single drug regimens. Even the combination of SM·EPAS·EINH was not exceptional, though these three drugs usually show unfavorable effects in the separate use.
Though the combined effects in these triple-drug regimens vary rather equivocally in each strain, the combination of KM·EINH·EEB showed considerably better results than others.
Four combinations including RFP were more potent than others in their inhibitory effects. As the difference in the inhibitory effect between RFP alone and the combined regimen was rather small, the advantages of combining the drugs with RFP were further to be studied.抄録全体を表示PDF形式でダウンロード (893K) -
I. 単独あるいは併用による間欠投与近藤 螢子, 金井 興美1977 年 52 巻 7 号 p. 339-343
発行日: 1977/07/15
公開日: 2011/05/24
ジャーナル フリーTherapeutic effects of intermittent drug administration in various regimens were compared by the time-course observation of the altered fate of tissue viable counts in experimental mouse tuberculosis.
It was shown that intermittent chemotherapy with increased single dose of ethambutol (EB) or rifampicin (RFP) can gain the therapeutic effect almost comparable, if not superior, to that achieved by daily administration with divided dose of those drugs.
The effect was greatly enhanced when intermittent chemotherapy, even once a week regimen, was conducted with the combinations of isoniazid (INH) plus RFP, EB plus RFP, or INH plus EB plus RFP, but not so with INH plus EB.抄録全体を表示PDF形式でダウンロード (530K) -
国療化研第18次A研究国立療養所化学療法共同研究班1977 年 52 巻 7 号 p. 345-351
発行日: 1977/07/15
公開日: 2011/05/24
ジャーナル フリーNewly diagnosed moderately or far advanced culture-positive pulmonary tuberculosis in patients, 243 in number, were allocated at random to the following two regimens:
ST (Standard): SM 1.0g twice weekly+INH 0.3g daily+PAS 10g daily
Out of 243 cases, 59 were excluded due to various reasons. The remaining 184 cases (“IM”: 93 cases and “ST”: 91 cases) were analysed as to their clinical efficacy, while 225 cases were utilized for the analysis of adverse reactions. The back-ground factors were almost similer in both groups. Number of far advanced cases were 66 (71.0%) in IM and 70 (76.9%) in ST.
Drop-out cases during the first 6 months were 10 in “IM” and 13 in “ST”, and in the second 6 months they were 12 in “IM”and 32 in “ST”. As the difference in the drop-out cases during the second 6 months was statistically significant, the data in the second 6 months could not be comparable between the two groups.
The rate of negative conversion of tubercle bacilli by culture for all cases at 6 months was 100% in FEW j and 96.1% in “ST”, and for far advanced cases 100% and 94.8%, respectively. The rates of TM j at 3 and 4 months were significantly higher than the rates of “ST”. On the contrary, the rates of smear negativity of “IM” were lower than that of “ST” at each month. In “IM”, the rates of smear negativity were lower than those of culture negativity.
Two bacteriologic relapse cases were observed in the second 6 months in “IM”, and the organismus in one case were resistant to both SM and INH. It seems that the administration of INH and rifampicin only for 6 months is not safe enough to prevent the bacteriological relapse.
Daily use of SM 0.75g for 2 months was safety and effective.抄録全体を表示PDF形式でダウンロード (698K) -
主として切除肺病巣内の結核菌検索の成績から結核療法研究協議会 , Subcommittee on Surgical Treatment1977 年 52 巻 7 号 p. 353-360
発行日: 1977/07/15
公開日: 2011/05/24
ジャーナル フリーThe indication of surgical treatment for pulmonary tuberculosis should be changed with the advances in chemotherapy, as the surgical treatment is indicated after chemotherapy. Accordingly, the changes in the indication of surgical treatment with the introduction of rifampicin (RFP) were reviewed based on the bacteriological findings on culture of resected specimens.
The material consisted of 285 cases who had undergone pulmonary resection under the coverage of RFP at 23 institutions belonging to the Tuberculosis Research Committee (RYOKEN). They were divided into 5 groups; 29 original treatment cases with SM·INHP FP showing positive sputum, 125 retreatment cases with positive sputum, 111 retreatment cases with negative sputum, 15 retreatment cases with unknown findings of sputum and 5 original treatment cases with SM·INH RFP showing negative sputum, before the introduction of RFP.
The bacteriological examinations of tubercle bacilli on smear and culture were carried out for necrotic mass obtained aseptically from cavities or non-cavitary lesions of resected specimens just after the completion of operation in each case. The bacteriological findings were then evaluated in relation to the duration of negative sputum and of RFP treatment.
The culture positive rate of tubercle bacilli in the resected specimens was only 1.0% (1 case) among 98 cases with the duration of both negative sputum and of RFP treatment for more than 6 months.
One culture positive case was found in the retreatment cases with negative sputum before the introduction of RFP, and the reason of which could not be solved. Moreover, the positive rate was also the same in 32 cases with the duration of negative sputum for the period of 3 to 5 months after using RFP for more than 5 months. It was noticed that the proportion of smear positive-culture negative cases to culture negative cases in resected specimens was as high as 47.4%.
The following conclusion could be obtained on the indication of surgical treatment: Cases showing negative sputum for more than 6 months by applying RFP treatment might be excluded from the indication of surgical treatment in the near future. It is also most likely to exclude cases with negative sputum for 3 to 5 months from the indication of surgical treatment. However, the final decision should be made after waiting for the results of further researches, as many problems such as the viability of smear positive-culture negative tubercle bacilli still remained unsolved.抄録全体を表示PDF形式でダウンロード (1024K)
- |<
- <
- 1
- >
- >|