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Volume 55, Issue 1
Displaying 1-4 of 4 articles from this issue
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Harumi AIZAWA, Hideshige HAYASHI, Naoto YAMAMOTO1980 Volume 55 Issue 1 Pages 1-5
Published: January 15, 1980
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSWe studied two cases of pulmonary tuberculosis who had the episode of hypokalemic alkalosis and tetanic symptom during the treatment with Enviomycin (EVM). The role of EVM as a causative agent for the hypokalemia and tetanic symptom observed was suggested from the detailed studies on the above-mentioned patients and another hundred patients on the relationship of EVM administra tion and the changes in values of serum electrolytes. We observed later additional two patients of hypokalemia who had been treated with EVM and had persistent lumbago, pains in legs and headache. In these two cases, insulin and/or diuretica administered together with EVM might be partly respon sible for the hypokalemia observed. Adverse reactions of EVM such as tinnitus, hearing loss, head ache and others were observed in 17 cases or 16 percent of total 109 cases studied.View full abstractDownload PDF (619K) -
Tuberculosis Research Committee RYOKEN1980 Volume 55 Issue 1 Pages 7-13
Published: January 15, 1980
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSClinical effect of two regimens, INH·ERFP·EEB regimen (EB group) and INH·RFP·PZA regimen (PZA group), were compared in the chemotherapy for previously untreated cavitary pulmonary tuber culosis patients with positive sputum. Each regimen was given for six months and followed by the same or another regimen that was selected freely by attending doctors.
1. The smear results of PZA group at 2 months and 3 months was 73.8% and 90.2%, respectively. These results were slightly better than that of EB group which was 68.0% and 77.0%, respectively, but the difference was not significant. The culture results of two regimens were almost similar, 70.3% in PZA group and 67.1% in EB group at 2 months, 94.9% and 88.9% at 3 months.
2. Improvement of X-ray findings of two regimens was also almost similar.
3. The total incidence of adverse reactions of any sort reported for 6 months was 75.3% in PZA group and 37.2% in EB group. The difference was significant. Hepatitis, elevation of level of uric acid and arthralgia associated with pyrazinamide were frequently found and there were significant difference between two regimens. Pyrazinamide was terminated in 24.7% of the patients, among them 11% by hepatitis.View full abstractDownload PDF (820K) -
Shun IKEDA, Kiyoshi SHIMA, Masayuki ANDO, Haruhiko TOKUOMI1980 Volume 55 Issue 1 Pages 15-18
Published: January 15, 1980
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSThe inhibitory effect of the serum from 14 patients with pulmonary tuberculosis on the E-rosette formation of normal donor T-cell was studied. The results obtained were as follows:
1. Some of the serum from patients with pulmonary tuberculosis inhibited the E-rosette forma tion of the normal T-cells, when compared with the serum from normal subjects. Five of 14 cases used in this study showed the increased inhibitory rate of more than 10 percent, and observing by the type of lesions, 4 of 7 cases with F type and one of 7 cases with C type of GAKKEN classification showed increased inhibitory rate. The mean of the inhibitory rate was 8±2 percent in the serum of F type and 2±1 percent in those of C, type, respectively. Thus, the serum from F type showed more inhibitory effect than those of C type.
2. The serum from a case with F type which showed high inhibitory effect was fractionated into euglobulin, pseudoglobulin and albumin fractions by the ammonium sulfate saturation method, and the inhibitory effect of each fraction was studied. The inhibitory effect was found in the non-γ-globulin fractions of pseudoglobulin and albumin, but not in the euglobulin fraction.View full abstractDownload PDF (539K) -
Satoshi MORIKAWA1980 Volume 55 Issue 1 Pages 19-28
Published: January 15, 1980
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSIn 167 cases with sarcoidosis, involvements of eyes and bone, and unusual cases of acute onset type have been reported.
1. It is clinically very important to suspect the diagnosis of sarcoidosis from ocular findings. In our series intraocular lesions occured in 101 of 146 patients with sarcoidosis (69.2%) and were found more frequently than other reports. All patients with characteristic ocular involvement were finaly established their diagnosis as sarcoidosis by the histological examination, so we considered that not only bilateral hilar adenopathy (BHL) on chest roentgenogram but also four or more active signs of ocular findings are important criteria for the diagnosis of sarcoidosis.
2. In 7 of 130 patients with sarcoidosis, serum calcium levels were elevated at the time of diag nosis. Hypercalcemia had been persisted in only one patient, and there was no significant difference between patients with sarcoidosis and control subjects in the frequency of hypercalcemia.
3. We proposed the new diagnostic criteria of bone lesions in sarcoidosis. In 18 of 76 patients, characteristic roentgenographic lesions were revealed in the fingers and/or hand. Bone biopsy were performed in five patients, and epithelioid cell granuloma was found histologically in only one patient.
4. Nine cases of so-called acute on-set sarcoidosis were reported. Most of them were adolescent, with BHL on chest X-ray film and markedly inflammatory reactions such as the increased erythrocyte sedimentation rate, leucocytosis with a shift to the left and strongly positive CRP reaction. The responseto corticosteroid therapy was satisfactory and the prognosis of these patients was favourable.
5. Although the lung was affected in more than 88% of patients with sarcoidosis, there were 12% of sarcoidosis without any evidence on chest X-ray film. On the other hand 6 patients with BHL who were suspected sarcoidosis were pneumoconiosis (4), tuberculosis (1) and anthracosis. It was suggested that the diagnosis of sarcoidosis should be made histologically using tissue biopsy specimens, and the presence of BHL should not be overestimated.View full abstractDownload PDF (1723K)
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