結核
Online ISSN : 1884-2410
Print ISSN : 0022-9776
ISSN-L : 0022-9776
55 巻, 1 号
選択された号の論文の4件中1~4を表示しています
  • 相沢 春海, 林 秀茂, 山本 直人
    1980 年 55 巻 1 号 p. 1-5
    発行日: 1980/01/15
    公開日: 2011/05/24
    ジャーナル フリー
    EVM投与中にみられた痙攣発作の2症例の経過を報告しそれ以降のEVM投与例に副作用調査を行ない, 少なくも経月的に血清電解質を測定しえた症例について血清K・Ca値の変動と副作用との関連性を検討し次の結果を得た。
    1) EVM投与中に発生した痙攣発作は血清Kの低下と関連ありと認められた。
    2) 経月的に血清K値を測定できた70例中, EVM投与中に血清K値の低下を認めた2例にしつこい副作用の発生をみたが1例はインスリンを他の1例は利尿剤の投与をうけていた症例であつた。
    3) EVM投与109例の副作用総数は16%, そのための中止は6%と低かつた。
  • 結核療法研究協議会
    1980 年 55 巻 1 号 p. 7-13
    発行日: 1980/01/15
    公開日: 2011/05/24
    ジャーナル フリー
    Clinical effect of two regimens, INH·ERFP·EEB regimen (EB group) and INH·RFP·PZA regimen (PZA group), were compared in the chemotherapy for previously untreated cavitary pulmonary tuber culosis patients with positive sputum. Each regimen was given for six months and followed by the same or another regimen that was selected freely by attending doctors.
    1. The smear results of PZA group at 2 months and 3 months was 73.8% and 90.2%, respectively. These results were slightly better than that of EB group which was 68.0% and 77.0%, respectively, but the difference was not significant. The culture results of two regimens were almost similar, 70.3% in PZA group and 67.1% in EB group at 2 months, 94.9% and 88.9% at 3 months.
    2. Improvement of X-ray findings of two regimens was also almost similar.
    3. The total incidence of adverse reactions of any sort reported for 6 months was 75.3% in PZA group and 37.2% in EB group. The difference was significant. Hepatitis, elevation of level of uric acid and arthralgia associated with pyrazinamide were frequently found and there were significant difference between two regimens. Pyrazinamide was terminated in 24.7% of the patients, among them 11% by hepatitis.
  • 池田 俊, 志摩 清, 安藤 正幸, 徳臣 晴比古
    1980 年 55 巻 1 号 p. 15-18
    発行日: 1980/01/15
    公開日: 2011/05/24
    ジャーナル フリー
    The inhibitory effect of the serum from 14 patients with pulmonary tuberculosis on the E-rosette formation of normal donor T-cell was studied. The results obtained were as follows:
    1. Some of the serum from patients with pulmonary tuberculosis inhibited the E-rosette forma tion of the normal T-cells, when compared with the serum from normal subjects. Five of 14 cases used in this study showed the increased inhibitory rate of more than 10 percent, and observing by the type of lesions, 4 of 7 cases with F type and one of 7 cases with C type of GAKKEN classification showed increased inhibitory rate. The mean of the inhibitory rate was 8±2 percent in the serum of F type and 2±1 percent in those of C, type, respectively. Thus, the serum from F type showed more inhibitory effect than those of C type.
    2. The serum from a case with F type which showed high inhibitory effect was fractionated into euglobulin, pseudoglobulin and albumin fractions by the ammonium sulfate saturation method, and the inhibitory effect of each fraction was studied. The inhibitory effect was found in the non-γ-globulin fractions of pseudoglobulin and albumin, but not in the euglobulin fraction.
  • 森川 聡
    1980 年 55 巻 1 号 p. 19-28
    発行日: 1980/01/15
    公開日: 2011/05/24
    ジャーナル フリー
    In 167 cases with sarcoidosis, involvements of eyes and bone, and unusual cases of acute onset type have been reported.
    1. It is clinically very important to suspect the diagnosis of sarcoidosis from ocular findings. In our series intraocular lesions occured in 101 of 146 patients with sarcoidosis (69.2%) and were found more frequently than other reports. All patients with characteristic ocular involvement were finaly established their diagnosis as sarcoidosis by the histological examination, so we considered that not only bilateral hilar adenopathy (BHL) on chest roentgenogram but also four or more active signs of ocular findings are important criteria for the diagnosis of sarcoidosis.
    2. In 7 of 130 patients with sarcoidosis, serum calcium levels were elevated at the time of diag nosis. Hypercalcemia had been persisted in only one patient, and there was no significant difference between patients with sarcoidosis and control subjects in the frequency of hypercalcemia.
    3. We proposed the new diagnostic criteria of bone lesions in sarcoidosis. In 18 of 76 patients, characteristic roentgenographic lesions were revealed in the fingers and/or hand. Bone biopsy were performed in five patients, and epithelioid cell granuloma was found histologically in only one patient.
    4. Nine cases of so-called acute on-set sarcoidosis were reported. Most of them were adolescent, with BHL on chest X-ray film and markedly inflammatory reactions such as the increased erythrocyte sedimentation rate, leucocytosis with a shift to the left and strongly positive CRP reaction. The responseto corticosteroid therapy was satisfactory and the prognosis of these patients was favourable.
    5. Although the lung was affected in more than 88% of patients with sarcoidosis, there were 12% of sarcoidosis without any evidence on chest X-ray film. On the other hand 6 patients with BHL who were suspected sarcoidosis were pneumoconiosis (4), tuberculosis (1) and anthracosis. It was suggested that the diagnosis of sarcoidosis should be made histologically using tissue biopsy specimens, and the presence of BHL should not be overestimated.
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