結核
Online ISSN : 1884-2410
Print ISSN : 0022-9776
ISSN-L : 0022-9776
56 巻, 10 号
選択された号の論文の5件中1~5を表示しています
  • 束村 道雄, 水野 松司, 村田 浩
    1981 年 56 巻 10 号 p. 459-463
    発行日: 1981/10/15
    公開日: 2011/05/24
    ジャーナル フリー
    It has been shown recently that minocycline exhibits growth-inhibitory effect on Mycobacterium tuberculosis. In the present study, we studied the pattern of resistance development to this agent. A series of studies on this subject were done in this laboratory for various antituberculous agents. Ogawa egg medium was used. The level of resistance was estimated by the “actual count method”. It was expressed as the highest concentration of agent, on which 10 to 100 viable bacteria inoculated per medium can grow as countable colonies after incubation at 37°Cfor 4 weeks.
    The number of phenotypes of resistant mutants (number of the kinds of survival curves shown by strains each derived from single colony) was two in minocycline resistance. The upper limit of resistance (the highest concentration of agent on which test organisms that were obtained by repeated selections of resistant mutants can grow) was 50μg/ml, i. e., 50 fold of the level of resistance of the parent strain. Resistant mutants that show the highest level of resistance could be obtained by obligatory two-step pattern.
  • 第2編殺菌効果について
    山鳥 英世
    1981 年 56 巻 10 号 p. 465-470
    発行日: 1981/10/15
    公開日: 2011/05/24
    ジャーナル フリー
    In the previous paper, it was reported that the bacteriostatic effect on tubercle bacilli was observed by using the silicone-coated slide culture method with various concentrations of antituber culous drugs and Kirchner's medium replacing air either with N2, CO2 or O2 gas.
    It is very interesting that these gases influence the bactericidal effects of antituberculous drugs.
    In this report, the bactericidal effects were observed according to the length as well as concen trations of drugs used the culture time and the kind of gas.
    The conclusions were as follows:
    1) The bactericidal effects of various gases were minimal even if the experiment was continued for four weeks under drugless environment. And, the bactericidal effects differed greatly depending upon the drugs used.
    2) Under the conditions using N2, CO2 or O2 gases, the longer the contact time period with the several kinds of antituberculous drugs, the stronger the bactericidal effects.
    3) With O2 gas exposure, the bactericidal effects of several kinds of antituberculous drugs were stronger than with the exposure to N2 or CO2 gas.
    4) With respect to the antituberculous drugs used, RFP showed the strongest bactericidal effects compared with the other drugs even in two week time period. And, the influence by the kinds of gas exposure was least in RFP.
    5) The bactericidal effects of other antituberculous drugs under various gas exposure did not always show a higher grade bactericidal effects even with a higher drug concentration.
  • 本宮 雅吉, 青柳 昭雄
    1981 年 56 巻 10 号 p. 471-511
    発行日: 1981/10/15
    公開日: 2011/05/24
    ジャーナル フリー
  • 1981 年 56 巻 10 号 p. e1
    発行日: 1981年
    公開日: 2011/05/24
    ジャーナル フリー
  • 1981 年 56 巻 10 号 p. e2
    発行日: 1981年
    公開日: 2011/05/24
    ジャーナル フリー
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