All issues
Volume 57, Issue 10
Displaying 1-6 of 6 articles from this issue
- |<
- <
- 1
- >
- >|
-
[in Japanese]1982 Volume 57 Issue 10 Pages 507-512
Published: 1982
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSDownload PDF (1366K) -
Eiko KONDO, Koomi KANAI1982 Volume 57 Issue 10 Pages 513-517
Published: 1982
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSIn a series of our study on tuberculous infection at the cell membrane level we have been concerned with a possibility that free fatty acids released from membrane phospholipids may have an opportunity to act on the bacilli as a nutrient or a growth-inhibitor depending on their molecular species, amounts or the environmental conditions. As an extension along the line of study, this paper reportsthe effects of lysolecithin, another degradation product of phospholipids, on the growth of tuberclebacilli in vitro.
The effect was examined by adding various molecular species of lysolecithin to liquid media of aminimum composition to which tubercle bacilli had been inoculated. It was found that the effectis different depending upon the kind of constituent fatty acid; e.g. stearoyl-lysolecithin is growth-supportive but myristoyl-, palmitoyl and oleoyl-lysolecithin are bactericidal at a concentration of 0.2mm. Experiments with -[14C] -palmitoyl-lysolecithin revealed that tubercle bacilli can split it torelease 1- [14C] -free fatty acid and utilize it for the biosynthesis of bacterial phospholipids.
From these and other collateral experiments, it was suggested that tubercle bacilli were killedin the presence of lysolecithin by their own activity to degrade it releasing fatty acids toxic to them.View full abstractDownload PDF (794K) -
SUPPLEMENTED WITH TWEEN 80 AND PATHOGENICITY AGAINST MICE OF THE BACTERIA GROWN ON THE MEDIUMYoshitaka GOTO, Hiroshi TAKAHASHI, Tokutaro MATSUYA, Tohru TOKUNAGA1982 Volume 57 Issue 10 Pages 519-524
Published: 1982
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSComparative studies on the growth of 16 strains of Mycobacterium (M.) intracellulare on Ogawa'segg medium (Ogawa's medium) supplemented with or without 1% Tween 80 were carried out. Elevenstrains of M. intracellulare, mostly isolated freshly from patients of atypical mycobacteriosis (AM), showedexcellent growth on the medium supplemented with Tween but not on Ogawa's medium without Tween. Three strains of M. intracellulare showed almost the equal growth on the both media and 2strains showed less growth on the medium containing Tween 80 rather than Ogawa's medium.
These 5strains had been maintained by passing Ogawa's media without Tween more than at least 4generations.
Freshly isolated M. intracellulare showed higher virulence to CF1 mice in comparison with thosemaintained on Ogawa's medium for long time periods. Several passages on Ogawa's media with out Tween reduced the virulence of the bacteria. However, passages on media with Tween did not reducevirulence. These findings suggest that Ogawa's medium with Tween is useful for isolation of M. infracellulare from AM patients and from experimentally infected animals for the sake of getting better growthand of maintaining bacterial virulence. Based on these observations, it becomes possible to makethe mouse model of M. intracellulare infection, which will be described in a subsequent paper, and virulent strains of M. intracellure may benpracticable for establishment of experimental AM model.View full abstractDownload PDF (945K) -
4. Characteristics of the Development of Pulmonary TuberculosisHajime INAMOTO1982 Volume 57 Issue 10 Pages 525-529
Published: 1982
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSDialysis patients are known to be immunodeficient. In attempting to clarify the characteristicsof development of pulmonary tuberculosis in the dialysis patients, an epidemiological study was done.
The subjects were 7274 dialysis patients in 161 institutions including 150 patients withtuberculosis. Tuberculous lesions were documented in 137 patients. Among them 59 males and 26 females suffered from pulmonary tuberculosis; 45 males and 13 females had solely pulmonary tuberculous lesions, and 14 males and 13 females with pulmonary tuberculosis were accompanied withextrapulmonary tuberculous lesions.
As to the causative diseases for renal failure, the frequencies of kidney tuberculosis, chronic pyelonephritis and polycystic kidney were higher among the patients with pulmonary tuberculosis accompanying extrapulmonary lesions than those among the patients with solely pulmonary lesions and thoseamong all other dialysis patients.
The age-specific incidencies of pulmonary tuberculosis showed 2 peaks, one in the tens and anotherin the sixties of age. The age-specific incidence of pulmonary tuberculosis accompanying extrapulmonary lesions showed one peak in the forties. The pattern of the incidence was quite differentfrom each other.An increase of the incidence of pulmonary tuberculosis was observed 12 months before the initiation of dialysis therapy. The frequency became higher along with deterioration of kidney functionof the patients. The frequency reached the highest during the initial 3 months of dialysis therapy, then it came down along with the duration of dialysis therapy, although it remained higher than thatof the general population.
Past history of tuberculosis was seen in 64% of tuberculosis patients developed during dialysisin whom past history was documented.
Thus, the present study demonstrated a characteristic feature on the development of pulmonarytuberculosis in dialysis patients.View full abstractDownload PDF (860K) -
Hiroyuki TANIGUCHI, Shigeki YOKOYAMA, Masayoshi HASHIMOTO1982 Volume 57 Issue 10 Pages 531-535
Published: 1982
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSA case of miliary tuberculosis showing acute respiratory failure during pregnancy was reported.
A 26-year-old, eight months pregnant woman, was admitted to our hospital with a nonproductive coughand fever.
On admission, she was severely ill with dyspnea at rest, her temperature was 38.7°, pulse 132/min, respiratory rate 66/min and blood pressure 124/84mm Hg. Examination revealed basilar raleson both sides and an enlarged uterus consistent with an eight-month-pregnancy. A chest X-ray showed a diffuse miliary infiltrate scattered throughout whole lung especially in both lower lung fields witha partially confluent pattern. Laboratory examination revealed accelerated ESR, positive CRP, and increased 2-globulin. The PPD skin test was negative. Arterial blood gas level of the patientbreathing room air was as follows: P2CO2 48.5 TORR, P2CO2 29.3 TORR, pH 7.42. Initial smearsof sputum for acid fast bacilli were negative.
An ophthalmoscopic examination disclosed the presence of choroidal tubercles, and a bone marrowaspiration showed giant celled caseating granuloma, which was of great value in establishing diagnosisof miliary tuberculosis.Intensive therapy with anti-tuberculosis drugs (Isoniazid, 400mg, Rifampicin, 750mg, and Streptomycin, 1g daily) was started supplemented with the use of diuretics, aminophilline, digitalis, and O2. Corticosteroids were administered, which appeared to be effective in reducing systemic toxicity and faster roentgenographic resolution. Recovery from hypoxemia steadily continued.
The patient gave birth to a baby on June 23 and the baby had no signs of tuberculosis.
This case report emphasizes the fact that miliary tuberculosis may present an acute respiratoryfailure symptom which may respond rapidly to a treatment with early and intensive use of anti-tuberculosis drugs and, in some case, corticosteroids.View full abstractDownload PDF (7147K) -
RELAPSE OF TUBERCULOSISMasahiko YAMAMOTO1982 Volume 57 Issue 10 Pages 537-560
Published: 1982
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSDownload PDF (3516K)
- |<
- <
- 1
- >
- >|