巻号一覧
59 巻, 1 号
選択された号の論文の6件中1～6を表示しています
- |<
- <
- 1
- >
- >|
-
佐藤 博, 佐藤 研, 大泉 耕太郎, 本宮 雅吉, 今野 淳1984 年 59 巻 1 号 p. 1-4
発行日: 1984/01/15
公開日: 2011/05/24
ジャーナル フリーDiabetes mellitus was found in 114 (6.2%) out of 1, 832 patients with pulmonary tuber culosis who had been admitted for more than 6 months. These cases were divided into groups according to the level of fasting blood sugar (FBS) level before starting the treatment for dia betes mellitus. The culture positivity was higher in high-FBS group and the cavities on chest X ray film were found more frequently in this group. However the culture negative conversion rate at 3 month after starting the treatment was 78%, and no significant difference in the rates was seen by the levels of FBS.
There was no difference in the degree of radiographic improvement between the two groups. The clinical course of tuberculous patients with diabetes was similar to that of non diabetic tuberculous patients. These results seem to indicate that diabetes, if it is well con trolled, does not influence the clinical course of tuberculosis.抄録全体を表示PDF形式でダウンロード (587K) -
予後ならびに死因分析について小西池 穣一, 旭 敏子, 喜多 舒彦, 横山 邦彦, 瀬良 好澄1984 年 59 巻 1 号 p. 5-11
発行日: 1984/01/15
公開日: 2011/05/24
ジャーナル フリーThe prognosis and causes of death of silico-tuberculosis treated with chemotherapy were investigated in 146 cases with positive sputum and 111 cases with negative sputum for tubercle bacilli admitted to our hospital during the past 28 years.
The results were summarized as follows:
1. The prognosis was closely related with bacteriological status during treatment; it was favourable in cases converted to negative by chemotherapy, while it was poor in cases failed to convert to negative.
2. Among 76 total dead cases, 29 cases (38.2%) were due to tuberculosis mainly with positive sputum and 47 cases (61.8%) were due to non-tuberculous diseases. Among them, cardio pulmonary insufficiency and terminal pneumonia, both having close relation with far ad vanced silicosis, were most frequent, then malignant tumors and cerebro-vascular disorder.
3. Yearly changes in the proportion of tuberculosis and of non-tuberculous deaths were observed, and the former has been decreasing, while the latter has shown marked increase year by year.
The average age of death among silico-tuberculous cases has become higher and is gradually approaching to the average span of life of males.
4. From the results of the study on the course and prognosis of silico-tuberculous cases, it is emphasized that the duration of chemotherapy could most likely be shortened by the introduction of intensive treatment at the initial stage of the diseases and the promotion of comprehensive health care for silico-tuberculous cases to control daily life through mental and physical guidance is necessary and important.抄録全体を表示PDF形式でダウンロード (951K) -
久世 文幸, 李 啓充1984 年 59 巻 1 号 p. 13-25
発行日: 1984/01/15
公開日: 2011/05/24
ジャーナル フリーIn order to establish a small animal model of Mycobacterium avium-intracellulare infection suitable for in vivo evaluations of chemotherapeutic regimens, ten strains were elaborately studied on the virulence to ddY conventional mice. The Log Ratio of the multiplication of bacilli in lung during the period of four weeks, from three to seven weeks of intravenous infection, was used as a main index for selection of a suitable strain for the model. After three consecutive repetitions of the same intravenous infection with the all ten strains, one of the strains, 31F093T, revealed itself to be reasonably virulent to the mice. The mice constantly showed miliary lung lesions, which became grossly visible at seven weeks of infection, with the mean Log Ratio of 2.3. Moderate to marked enlargement of both spleen and liver with gross diseases was also usual findings at the seventh week of infection.
Three mycobacterial strains, M. tuberculosis (H37Rv), M. kansasii (KMC 1113), and M. avium-intracellulare (31F093T), were injected intravenously to ddY conventional mice. Histopathologic findings as well as other parameters were evaluated in these three mycobacterial infections in mice. The murine infection with 31F093T strain was obviously more chronic and persistent than the murine tuberculosis caused by H37Rv. The histopathologic findings of the mice infected with M. avium-intracellulare 31F093T were those of granulomatous to diffuse proliferative changes in lung with extensive granuloma formation in bothspleen and liver. No necrotic changes were demonstrated in the lungs of mice infected with 31F093T strain, while the changes were frequently observed in the lungs of moribund mice infected with H37Rv. No deaths due to the infection ensued in the mice infected with M avium-intracellulare 31F093T during the who'e period of 23 weeks. M. kansasii KMC 1113 provoked the disease earlier than 31F093T strain, and a spontaneous regression of the disease was suggested in kidney and liver beyond eleven weeks of infection, though the disease in lung persisted until the end of the observation.
Five different strains of mice, ddY, C31-1/1-1e, ICR, BALB/c, and C57BL/6, were evaluated for their susceptibilities to 31F093T strain. Besides the intravenous model with ddY strain, both intravenous model with BALB/c and intraperitoneal model with C57BL/6 also demonstrated their probable usabilities for the infection models of murine M. avium-intracellulare infection.抄録全体を表示PDF形式でダウンロード (5377K) -
Substrate film法による新しい試み吉松 哲之, 津田 富康, 鬼塚 徹, 水城 まさみ, 岡嶋 透1984 年 59 巻 1 号 p. 27-31
発行日: 1984/01/15
公開日: 2011/05/24
ジャーナル フリーLocalization of ACE (angiotensin-converting enzyme) and its activity in the experimental pulmonary granuloma of rabbit were studied by ACE substrate film prepared from hippuryl L-hystidyl-L-leucine and purified calfskin gelatin. The pulmonary granulomas were produced in the rabbits by intravenous injection of 1.0ml of Freund's complete adjuvant or 40mg of Japanese strain of Bacillus Calmette-Guerin (BCG). At 5, 14, 21, 28, 35, 42, and 49 days after injection, the resulting pulmonary lesions (granulomas) were obtained from the rabbits exsanguinated by severing the femoral artery. Serum ACE activities were also examinated at each period.
The granulomas produced by Freund's complete adjuvant at 21 and 28 days of age showed high ACE activity. The activity was seen as numerous sharply defined vacuoles on the substrate film under the epithelioid cells. Those of 42 days of age showed low activity. On the other hand, the granulomas produced by BCG showed generally low ACE activity and the activity was only seen as poorly defined and poorly stained plaques in the granulomas at 14 day of age. The serum ACE levels and the tissue ACE activities changed in a same way through the experi mental course.
These findings show that ACE substrate film technique is available for determination of localization and activity of ACE and that most of increased serum ACE in this experiment may originate from tissue ACE in the granulomas.抄録全体を表示PDF形式でダウンロード (4196K) -
束村 道雄1984 年 59 巻 1 号 p. 33-37
発行日: 1984/01/15
公開日: 2011/05/24
ジャーナル フリーTen patients with lung disease due to Mycobacterium avium-M. intracellulare complex were treated by a combination of sulfadimethoxine, minocycline and kitasamycin for 8 to 15 months, and seven showed negative conversion of sputum cultures. On the other hand, only six of 43 patients treated with various combinations of antituberculous drugs showed negative conversion. There was a statistically significant difference between these two groups (P<0.005). The doses used in a new regimen were as follows: Sulfadimethoxine, 1g daily; minocycline, 100mg daily; kitasamycin, 600mg (or 1200mg) daily. These drugs were given to patients as single dose (per os). For initial three months of treatment, 1200mg of kitasamycin were given daily at three times, each time 400mg. No significant side effect was observed in the patients who received the new regimen, except for one patient showed decrease of the white blood cell count (7000/mm3 to 4000/mm3) after administration for 13 months. Two patients who received the new regimen showed also disappearance or marked decrease in size of cavities.抄録全体を表示PDF形式でダウンロード (850K) -
三上 理一郎1984 年 59 巻 1 号 p. 39-63
発行日: 1984/01/15
公開日: 2011/05/24
ジャーナル フリーThe onset pattern of pulmonary tuberculosis has changed remarkably during the past three decades: now-a-days, the onset soon after the primary infection has reduced notably, and most cases of pulmonary tuberculosis came out from previously infected ones. Immunology has progressed so strikingly that the role of T-cells, macrophages, etc., in the development of tuberculosis has been elucidated to a certain extent.
The auther, as a clinician, tried to clarify the mechanism of the onset of tuberculosis taking into account recent advances in immunology.
1. By the case-control study of newly registered tuberculosis cases at health centers in Nara Prefecture, it was found that some factors of daily life and work which might cause stress and the reduction of obesity-index were seen more frequently in tuberculosis cases than in the control. As one of causes of dominance of male over female in new tuberculosis patients over 30 years of age, more stress in male by their hard work is suspected. The fact that 40% of new cases were in the age gro'ips over 60 years can be explained by higher risk of tuberculosis in the aged due to their slimness and limited physical exercise.
2. Asa parameter of immunological responses, skin reaction (PPD-test, DNCB-test), KLH reaction, NK-cell-activity and lymphocyte subset analysis were utilized. The results were as follows:
1) Decrease of PPD reaction in active pulmonary tuberculosis was 13%, while decrease of DNCB response was found in 64%.
2) NK-cell-activity-level showed high value.
3) Cases with high level T-cell subset Th/Th were seen relatively common, and it seems being due to the decrease of Leu 2a% value.
3. In active pulmonary tuberculosis (160 cases):
1) Fall of DNCB response seemed to be higher in patients older than 50 years.
2) It was found that there was some correlation between reduced DNCB response and reduction of obesity-index.
3) Correlation between reduced DNCB response and decrease of lymphocytes or gamma globulin-increase in serum was found.
4. Chonic excretors of tubercle bacilli could be grouped into three, based on cellular immunity:
1) High reacting type (with high and increased NK-activity, normal DNCB response).
2) Mid-type.
3) Low reacting type (with non-increasing NK-activity, low DNCB response).
Chest X-ray findings of some cases of high reacting type were stable, while that of many cases of low reacting type showed aggravation.
It was suggested that factors relating to the onset of pulmonary tuberculosis in the major ity of previously infected persons were abnormal behavior pattern in their life and work and the reduction in cellular immunity of the host.抄録全体を表示PDF形式でダウンロード (5417K)
- |<
- <
- 1
- >
- >|