巻号一覧
59 巻, 4 号
選択された号の論文の5件中1～5を表示しています
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松島 敏春, 原 宏紀, 荘田 恭聖, 加藤 収, 川根 博司, 副島 林造1984 年 59 巻 4 号 p. 269-275
発行日: 1984/04/15
公開日: 2011/05/24
ジャーナル フリーTen patients with concomitant pulmonary mycobacteriosis and cancer who had beenadmitted during the past nine years, were studied clinically.
Five cases had both active pulmonary mycobacteriosis and lung cancer on admission. Inthese patients, the tuberculous lesions were limited or moderate, and antituberculouschemotherapy was mostly effective.
The tuberculous lesions were detected only at autopsy in two patients with lung cancer.Though the lesions were limited with negative sputum culture, it was considered that thetuberculous lesions could develop more advanced, if the patients survived longer.
Antituberculous chemotherapy was not effective in two out of three patients withconcomitant pulmonary mycobacterial infections and the cancer of organs other than lung, probably due to deteriorated host defence mechanisms under terminal cancer status.
Median survival time of seven lung cancer patients with mycobacteriosis was 16.5months, which was 8 months longer than the mean survival time of conservatively treatedlung cancer patients in our hospital.抄録全体を表示PDF形式でダウンロード (959K) -
鈴山 洋司, 重野 芳輝, 重野 秀明, 中里 博子, 長沢 正夫, 古賀 宏延, 富田 弘志, 朝長 昭光, 山口 恵三, 泉川 欣一, ...1984 年 59 巻 4 号 p. 277-287
発行日: 1984/04/15
公開日: 2011/05/24
ジャーナル フリーA 9-month regimen of daily ethambutol, isoniazid and rifampicin supplemented for thefirst one month by daily streptomycin and for the next two months by twice a weekstreptomycin (1SEHR/2S2EHR/6EHR) was given to 146 patients with newly diagnosedpulmonary tuberculosis, and the results were compared with those of 9-month regimenwith EB, INH, RFP (9EHR) as previously reported.
1. The rate of sputum conversion at 2 months and the 3 months was 78.8% and 96.5%, respectively. The result at 2 months was inferior to that (90.8%) of 9EHR regimen, butthe differences at 3 months and 4 months were not significant.
2. Improvement of chest-X-ray findings of two regimens was almost similar.
3. In the 43 out of 85 initially culture positive cases observed from 6 to 36 months afterthe completion of therapy, no bacteriological relapse was seen, but one patient relapsedradiographically.
4. Of the initial 146 patients, 36 (24.7%) had side effects and 26 (17.9%) had toterminate treatment because of drug toxicity, mainly due to streptomycin. It wasconcluded that the addition of streptomycin in the initial phase of short-coursechemotherapy had no effect on the rate of culture conversion and was contributing to theincreased incidence of adverse reactions, although background factors among the patientsstudied were a little bit different with those in 9 HER group.抄録全体を表示PDF形式でダウンロード (1535K) -
BCG株を他のMycobacterium bovis株から区別する方法束村 道雄, 東海林 黎吉, 松田 啓子1984 年 59 巻 4 号 p. 289-293
発行日: 1984/04/15
公開日: 2011/05/24
ジャーナル フリーAcid-fast organisms isolated from tuberculous lymphadenitis-leison of two childrenvaccinated with BCG were identified as BCG. The following characteristics of the BCGstrain were considered as useful for differentiating BCG from other strains of M. bovis: 1) weakly positive reaction of the niacin test; 2) weakly positive reaction of the nitratereduction; 3) growth on a synthetic medium containing glucose as the sole source ofcarbon in the presence of ammoniacal nitrogen; 4) growth on a synthetic mediumcontaining nitrate as the sole source of nitrogen in the presence of glycerol-carbon; 5) growth on a modifed Sauton agar medium (glutamate was substituted for asparagine); 6) considerable growth on the Sauton agar medium containing 0.1% picric acid (pH7.0); 7) growth on Ogawa egg medium containing thiophene-2-carboxylic acid hydrazide, 1μg/ml 8) formation of rough eueonic colonies on Ogawa egg medium.
In addition, the following two may be shown: (a) growth on Ogawa egg mediumcontaining sodium salicylate, 0.5mg/ml; (b) growth on Ogawa egg medium containing NH2OH. HCl, 0.125mg/ml.
Other M. bovis strains do not show the above characteristics.抄録全体を表示PDF形式でダウンロード (768K) -
近藤 瑩子, 鈴木 健之, 金井 興美1984 年 59 巻 4 号 p. 295-302
発行日: 1984/04/15
公開日: 2011/05/24
ジャーナル フリーA non-ionic detergent of Triton WR-1339 (oxyethylated tert. octyl phenol polymer) modified the course of experimental mouse tuberculous infection as to prolong theirsurvival time. Though it is not lytic to red blood cells and the lysosomes, this detergentexert a subtle effect on the biomembrane as evidenced by cold-shock experiment ofhaemolysis. This means that Triton WR-1339 has a strong affinity to the biomembrane, if not lytic. Electron-microscopy demonstrated that BCG organisms ingested intomacrophages were within the phagosome which appeared to be filled with the detergent.Discussion was made from these observations that the detergent may inhibit the interactionbetween mycobacteria and the phagosomal membrane by intervening between them thusmaking the progress of infection delayed.抄録全体を表示PDF形式でダウンロード (2914K) -
伊東 秀夫, 藤平 隆司, 原田 進, 城戸 優光, 加治木 章, 中島 康秀, 黒岩 昭夫1984 年 59 巻 4 号 p. 303-308
発行日: 1984/04/15
公開日: 2011/05/24
ジャーナル フリーAccelerated inactivation of corticosteroids following rifampicin therapy has beenrecognized. We observed nonresponsiveness to prednisolone treatment during rifampicinadministration in a case of systemic lupus erythematosus with diffuse alveolitis andconcomitant apical tuberculosis.
A 51 year-old woman complained in September 1980, of polyarthralgia and butterflyerythema of the face. From typical clinical manifestations and positive serological tests, systemic lupus erythematosus was diagnosed and treatment with prednisolone was startedat a local hospital. To prevent exacerbation of old apical tuberculosis, isoniazid 0.2 gdaily was also administered. Good response was obtained for an initial few months butdyspnea, diffuse pulmonary infiltrates appeared following prednisolone decrement.
She was transfered to our hospital in August 1981. On admission, she had a few skinulcers in bilateral hands and pigmentations over the surface of shoulder, elbow and knee.Velcro rales were audible over the lung base. No lymphadenopathy was detected.Laboratory examination revealed positive RA test, antinuclear and anti-DNA antibody. Thyroid test and microsome test were also positive, but LE test, RNP antibody, SMantibody were negative. C4, CH50 were normal but C3 was decreased. Chest X-Prevealed diffuse reticular shadows in bilateral middle and lower lung field and nodularconsolidation in right apical region. Although tubercle bacilli was negative in sputum, exacerbation of tuberculosis were suspected radiologically. Histological specimen obtained by transbronchial lung biopsy from the left lung showed mild interstitial thickening of alveoli with mononuclear cell infiltration.
Prednisolone was increased from daily dose of 5mg to 80mg and 450mg of rifampicin, 1, 000mg of ethambutol were added, but no response was obtained. In December 1981, prednisolone was altered to equivalent dose of betamethasone but minimal improvementwas observed.
After quitting rifampicin on January 1982, dramatic improvement in symptoms, laboratory data and chest roentgenogram was achieved. Although pharmacokineticstudies were not performed, we feel that the circumstantial evidence suggests strongly toincreased metabolism of prednisolone by rifampicin-induced microsomal enzymes.抄録全体を表示PDF形式でダウンロード (2298K)
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