巻号一覧
60 巻, 10 号
選択された号の論文の5件中1～5を表示しています
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下方 薫, 戸谷 康信, 河地 英昭, 岸本 広次, 丹羽 義置, 恒川 博, 高木 英志, 溝口 健二, 長谷川 好規1985 年 60 巻 10 号 p. 505-508
発行日: 1985/10/15
公開日: 2011/05/24
ジャーナル フリーTuberculosis patients who were admitted to general wards in our University Hospital were studied. Sixty-two patients were proved to be tuberculosis and transferred to the tuber culosis ward from 1976 to 1982. In this period, 426 patients were admitted in tuberculosis ward, and 46247 patients were admitted to our hospital.
The rate of tuberculosis patients transferred to the tuberculosis ward was 0.13%. They were transferred almost all wards (i.e., internal medicine, surgery, neurosurgery, orthopedics, otorhinolaryngology, ophthalmology, anesthesiology, oral surgery, urology, gerontology and radiology).
Major diseases complicating tuberculosis were diabetes mellitus, malignancies and collagen diseases. On admission and in cases with persistent fever and productive cough, a routine chest roentgenogram was strongly recommended for any patients and a sputum smear examination was also recommended in patients with respiratory symptoms.抄録全体を表示PDF形式でダウンロード (501K) -
(結核性髄膜炎・中枢神経系結核について)-国療化研第26次B研究報告国立療養所化学療法研究会1985 年 60 巻 10 号 p. 509-515
発行日: 1985/10/15
公開日: 2011/05/24
ジャーナル フリーOut of the extrapulmonary tuberculous patients, admitted to the 39 institutions of national sanatoria during the past five years (1978-1982), 29 cases (3.9%) were diag nosed as tuberculous meningitis (25 cases) and tuberculosis of central nerve system (4 cases).
According to their clinical individual cards, 21 were male and 8 were female, and the average age was 32.5 years old (1-68 years old).
Clinical and bacteriological diagnosis was mainly performed by the clinical symptolns, tuberculin skin test, brain CT scanning and tubercle bacilli in cerebrospinal fluid.
The most common symptoms elicited by the individual cards were fever, headache, disturbance of consciousness, stiffness of the neck, nausea, vomit and other neurologic symptoms.
Out of 29 cases, complicated pulmonary or other extrapulmonary active lesion, in which pulmonary one chiefly occupied, was observed in 24 cases (82.8%) at the starting point of chemotherapy.
The therapeutic effects of regimens including RFP·EINH for the tuberculous meningi tis and tuberculosis of central nerve system were observed.
The duration of these chemotherapy was about twelve months in average and re sponse to therapy indicated the marked improvement in ten cases (34.5%), but dead cases also were observed in the same numbers.
In five cases, neurologic sequelae were found and they received the surgical treat ment or physical rehabilitation for these sequelae with considerable improvement.
From the results of this study, it is emphasized that early diagnosis and initial inttensive chemotherapy including RFP·EINH for tuberculous meningitis and tuberculosis of central nerve system are necessary to bring the favorable prognosis which is considered to increase survival rate and to decrease neurologic sequelae.抄録全体を表示PDF形式でダウンロード (831K) -
束村 道雄, 水野 松司1985 年 60 巻 10 号 p. 517-521
発行日: 1985/10/15
公開日: 2011/05/24
ジャーナル フリーMycobacterium tuberculosis strains H37Rv and Aoyama-B and Mycobacterium bovis strains Ravenel and BCG (Japan) developed two phenotypes of mutants resistant to ofloxacin. Higher resistance was obtained only by inoculating lowly resistant strains on media containing high concentrations of ofloxacin. From parent strains, only lowly resistant mutants were isolated. Therefore, the pattern of resistance development of tubercle bacilli to ofloxacin is two step-pattern. Both lowly and highly resistant strains showed the same biological and biochemical characteristics as had the parent strains. Virulence to mice of the resistant strains were the same as that of the parent strains.抄録全体を表示PDF形式でダウンロード (424K) -
中村 玲子1985 年 60 巻 10 号 p. 523-529
発行日: 1985/10/15
公開日: 2011/05/24
ジャーナル フリーTuberculin skin reaction is one of phenotypes of the immune responses to mycobacteria, which is mediated by the sensitized T cells and expressed as a delayed-type hyperse nsitivity. In mycobacteria-infected mice, this response is recognized as a footpad reaction specific to PPD. There are high and low responders in this reaction among various strains of mice. The difference in the responsiveness is controlled genetically. High respon siveness is dominant over low responsiveness. The results of linkage test using SWM/Ms, C3H/ He, and their hybrids, showed that this gene links to neither H-2, coat color, norIgh allotype.
Strain differences in the resistance against virulent mycobacterial infection does not coincide with the natural resistance to BCG which is regulated by Ity-Bcg-Lsh gene on chromosome 1. Rather, the acquired immunity is related to delayed-hypersensitivity to BCG, although it is not mapped yet.
Suppression of the immune response to BCG is observed in BCG-low-responder mice. The mechanism was found to be due to the induction of suppressor T cells which inhibit the induction of effector T cells. The surface antigens on macrophages and T cells are necessary to induce suppressor T cells. It seems that the suppressor T cell induction is regulated genetically. However, it is not clear what gene regulates the suppressor T cell induction and how it is related with the gene for delayed-type hypersensitivity.
Genetic analysis of immunity to tuberculosis in human beings is difficult because the population is highly heterogeneous. Statistical analysis in a large scale would be a good way of the study. There is a report that HLA-Bw 15 might be related to tuberculosis, but accumulation of more information is necessary.抄録全体を表示PDF形式でダウンロード (877K) -
1985 年 60 巻 10 号 p. 531-556
発行日: 1985/10/15
公開日: 2011/05/24
ジャーナル フリーPDF形式でダウンロード (2882K)
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