巻号一覧
60 巻, 12 号
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阿児 博文, 三上 理一郎, 坂口 泰弘, 堅田 均, 沢木 政好, 前川 純子, 米田 三平, 成田 亘啓1985 年 60 巻 12 号 p. 609-616
発行日: 1985/12/15
公開日: 2011/05/24
ジャーナル フリーAlcoholics are known to have a high frequency of pulmonary tuberculosis. There have been no report concerning to the relationship between tuberculosis and alcoholism in Japan.
147 male patients with active pulmonary tuberculosis were studied for alcohol consumption. Patients were classified into three groups: “habitual” drinkers, “heavy” drinkers, and “non-habitual” drinkers on the basis of the extent of alcohol consumption. Habitual drinkers were defined by those who drink 540 ml or more of sake daily over five years or an equivalent amount of alcohl in other beverages. Heavy drinkers were defined by those who drink 900ml or more of sake daily over ten years. The remainder were defined as non habitual drinkers.
Of 147 patients, 16 patients were habitual drinkers, 19 were heavy drinkers, 112 were non habitual drinkers. No statistically significant differences were observed in chest Xray findings and response to therapy. Heavy drinkers were found to smoke much more than non habitual drinkers. In heavy drinkers there was high incidence of negative reaction of immunological skin tests than that on non habitual drinkers. The incidence of both diabetes mellitus and chronic liver disease in heavy drinkers was significantly higher than that in non habitual drinkers.
Humoral and/ or cellular immunity were known to be depressed in diabetes mellitus and liver cirrhosis. Many investigators have tried to determine why tuberculosis is common among alcoholics. However, no predisposing factors were demonstrated conclusively. Our data suggest that complications such as diabetes mellitus and/or liver cirrhosis may play a role in the pathogenesis of pulmonary tuberculosis in alcoholics.抄録全体を表示PDF形式でダウンロード (3164K) -
国立療養所化学療法共同研究会長澤 誠司, 浦上 栄一, 国立療養所化学療法共同研究会1985 年 60 巻 12 号 p. 617-623
発行日: 1985/12/15
公開日: 2011/05/24
ジャーナル フリーCSUCT carried out one year's follow up of the originally treated cases, 1541 in number, admitted to 54 national sanatoria in 1980 and the results were compared with those of the same study in 1970.
The background factors of patients at the time of admission were nearly the same as those of the last study, but proportion of old age group and of patients with complications were increased significantly.
The standard regimen of chemotherapy at the time of the previous study was SM, INH plus PAS and now it was changed to INH-ERFP plus SM or EB. Although negative conversion of tubercle bacilli become rapid and sure, duration of chemotherapy was still longer than the standard duration which was recommended by the Japanese Society for Tuberculosis in 1980.
The patients of discharged after improvement were increased and the patients of stayed in sanatoria were decreased, but period of hospitalization was seemed to be unnecessaril y long.
The dead patients were increased and of 72% died from illness other than tuberculosis.抄録全体を表示PDF形式でダウンロード (781K) -
津田 富康, 吉松 哲之, 鬼塚 徹, 青木 隆幸, 安部 康治, 杉崎 勝教1985 年 60 巻 12 号 p. 625-628
発行日: 1985/12/15
公開日: 2011/05/24
ジャーナル フリーSince serum angiotensin-converting enzyme (S-ACE) has been reported to be elevated in sarcoidosis and other granulomatous diseases but normal in pulmonary tuberculosis, tissue angiotensin-converting enzyme (T-ACE) activity in tuberculous lesions obtained by operation and biopsy (pulmonary lesion, cervical lymph node and pleural specimen) was studied by ACE substrate film method.
Consequently, TACE activity in tuberculous lesions was clarified to be seen in the area of epithelioid cells but not in caseous necrotic center of the granulomas.
This result suggests that T-ACE is no value in distinguishing tuberculous epithelioid cells from sarcoid epithelioid cells. It is important that why discrepancy between S ACE level and T-ACE activity is developed in tuberculosis in contrast to sarcoidosis.抄録全体を表示PDF形式でダウンロード (4755K) -
青木 国雄1985 年 60 巻 12 号 p. 629-642
発行日: 1985/12/15
公開日: 2011/05/24
ジャーナル フリーThe objective of this study is to determine what type of correlations, if any, exists between pulmonary tuberculosis and lung cancer from the epidemiological point of view, and to detect some common and/or specific risk factors to both tuberculosis and cancer. Because the coexistence of lung cancer among pulmonary tuberculosis patients has frequently been reported from various areas in Japan and other countries, and there has been an interesting hypothesis on the relationship between both diseases since the beginning of this century.
The results are as follows:
1. In the death certificate studies, the deaths from lung cancer have had a significantly high prevalence rate of advanced tuberculosis in both Japan and USA.
2. In the autopsy series in 1974-1982, Japan, the cases diagnosed as lung cancer pathologically have had a significantly high rate of advanced pulmonary tuberculosis, but not high rate among the other diseases such as gastric cancer, heart and cerebrovascular diseases.
3. The cumulative death rates up to 84 years from birth or 5 years of age were estimated based on the age-sex specific death rates of tuberculosis and cancer in Japan. The estimated cumulative combined rate of tuberculosis and cancer was approaching 20% of the birth cohorts born between 1950 and 1975 for males and 15% for females, and there is no significant difference in the rates between the birth cohorts. These proportions were very similar to those of England? Wales, Scotland and New Jersey in USA. During the period of 1950 to 1980, the death rate of tuberculosis decreased markedly, while those of lung cancer steeply increased. And the death rates of other cancers have been stable or showed only minor changes.抄録全体を表示PDF形式でダウンロード (1773K)
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