All issues
Volume 61, Issue 7
Displaying 1-4 of 4 articles from this issue
- |<
- <
- 1
- >
- >|
-
Report Of The 26th A Series Of Controlled Trials1986 Volume 61 Issue 7 Pages 363-369
Published: July 15, 1986
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESS148 pulmonary tuberculosis patients without previous chemotherapy were treated by the regimen that included 2 months of SM (or EB), INH, RFP and PZA, followed by EB, INH and RFP. Drug dosage was INH 0.3g, RFP 0.45g, PZA 1.0-1.5g, SM 0.75-1.0g and EB 0.75-1.0g respectively. The chemotherapy was administered for 6 months after negative conversion of sputum by culture. Patients were followed up for 12 months after the cessation of chemotherapy.
The rate of negative conversion by culture was 79.7% at the 2nd month and 100% at the 6th month. It seemed that this result was almost similar to those in the previous trials of the short-ourse chemotherapy of the 19 · 20th A, 21st and 22nd series. Out of 47 cases who were followed up for more than 12 months after stopping chemotherapy, one case with single isolation of tubercle bacilli was observed. The incidence of adverse reactions induced by PZA was 24.4%.View full abstractDownload PDF (683K) -
(1st study: ) Twelve and Eighteen-month Chemotherapy with Rifampicin-Isoniazid and EthambutolHarutaka BABA, Akihiko SHINKAI, Rokuro IZUCHI, Yo AZUMA1986 Volume 61 Issue 7 Pages 371-377
Published: July 15, 1986
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSThis controlled clinical study was carried out to investigate the possibility of reducing the duration of chemotherapy by using rifampicin combined with other drugs and also to see if there could be no relapse even if the duration of follow-up was prolonged.
In the first study, initiated on May 1974, two different duration of the regimen rifampicin-isoniazid-ethambutol-12 months (A) and 18 months (B) allocated at random was studied. The criteria to the study: Patients should be admitted to our hospital, have pulmonary tuberculosis with at least one cavity and sputum smear positive, previously untreated or treated less than 15 days.
A total of 219 patients were enrolled into the study, 100 in group A, 119 in group B. But after reducing the unsuitable patients who did not meet the protocol requirements, 86 (A) and 92 (B) have remained for the final analysis.
The background factors were almost the same in each group (Table 1). All cases converted within 4 months (Fig. 1) More than one third of the cavities remained open when the treatment was completed (Table 2). Adverse reactions were seen in 16% among the total of 219 cases. Especially the liver dysfunction was seen in 4 patients (2%).
It has now elapsed 9 (A) and 8.5 years (B) after stopping the chemotherapy. Owing to the progressing lack of communications with the patients as the time elapsed, we could not make a through investigation (Fig. 2). Although there was no relapse until 24 months, one relapsed bacillary in the 28th month (B), of whose cavitary lobe had been resected following to the sputum conversion and the resected specimens were all culture negative.
In group A, 3 cases relapsed (2 bacillary and 1 only radiological): one in the 59th month, the second in the 66th month who was an uncontrolled diabetic and relapses occurred 2 times and the third, radiologically relapsed, in the 33th month who was also diabetic (Table 4).
The bacilli of these 3 patients were sensitive as they were before and the patients were treated effectively with the same regimen (Table 5). If we confine the duration of follow-up to the period of 24 months, there was no relapsed case in each group but when the duration of follow up was prolonged, even with 18 month treatment of the regimen-rifampicin-isoniazid-ethambutol, we could not prevent from the relapses perfectory.View full abstractDownload PDF (833K) -
Junko MAEKAWA, Riichiro MIKAMI, Masanori YOSHIKAWA, Yasuhiro SAKAGUCHI ...1986 Volume 61 Issue 7 Pages 379-384
Published: July 15, 1986
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSIn 48 hospitalized patients with active pulmonary tuberculosis, nutritional status on the basis of obesity-index, anthropometric mesurement and some biochemical & hematological indices (total protein, total choresterol, trigliceride, lipoprotein, HDL-choresterol, hemoglobin and lymphocyte count) were assessed in reference to immunological-skin test (DNCB skin reaction). Patients group had significantly reduced obesity-index together with anthropometric parameters such as TSF, AC, AMC and also in serum total-and HDL choresterol levels than normal controls.
A large number of patients (32/48) showed reduced DNCB skin reaction, whereas only a few normal subjects (3/50) had showed reduced reactivity.
Some of the anthropometric indices (TSF, AC, ) serum albumin, hemoglobin and peripheral lymphocyte count were significantly lower in patients with reduced DNCB reaction than in patients with normal reactivity and normal controls. The data suggested a relationship between poor nutritional status and depressed cellular immunity in tuberculosis patients.View full abstractDownload PDF (585K) -
Bronchoplasty for Tuberculous StenosisShinya MURAKAMI, Yoh WATANABE, Hiroaki KOBAYASHI, Haruo KIMOTO, Takash ...1986 Volume 61 Issue 7 Pages 385-391
Published: July 15, 1986
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSIn the past eleven years, eight cases of bronchial tuberculosis or tuberculous stricture were operated on. Of the eight cases, the right upper bronchus was involved in three cases, the main and right upper bronchus in three, and the left main bronchus in two cases. These strictures were mostly induced by nonspecific granular tissue after healing of tuberulous bronchitis by anti-tuberculous treatment.
For three cases of cicatrical stricture confined to the orifice of the right upper bronchus without inflammatory changes of the main bronchus, right upper lobectomy were successfully performed without any postoperative complication. However, the three cases of right upper bronchus obstruction with cicatrical stricture or inflammatory changes in the main bronchus underwent sleeve upper lobectomy by resecting the right main bronchus.
In two cases, the left main bronchus were involved. One case developed atelectasis of the entire left lung due to cicatrical occlusion of the main bronchus during anti-tuberculous treatment, pneumonectomy was inevitable. In the other case of the left main bronchus stricture with complete obstruction of the left upper bronchus, the left upper lobe including the left main bronchus was resected, and side to end anastomosis between the trachea and the left lower bronchus was performed.
In the follow-up of the case of bronchial tuberculosis periodical observation by bronchoscopy and examination of respiratory function including flow volume curve should be done. We are considering bronchoplastic surgery should be performed before residual lung tissue were destroyed.View full abstractDownload PDF (3670K)
- |<
- <
- 1
- >
- >|