巻号一覧
61 巻, 9 号
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国療化研第27次A研究長澤 誠司1986 年 61 巻 9 号 p. 443-452
発行日: 1986/09/15
公開日: 2011/05/24
ジャーナル フリーIn 1984, CSUCT surveyed the clinical course of 594 cases who had been hospitalized in 36 national sanatoria from 1975 to 1979. All cases had been excreting tubercle bacilli for more than two years.
The results are as follows;
1. 251 cases (42.3%) died of pulmonary tuberculosis, and 44 cases (7.4%) became negative for excretion.
2. The mean death rate during five years from 1975 to 1979 was 8.9%. Chronic excretors showed maximum death rate (11.1%) in the 7th year from the initiation of excretion.
3. The causes of chronic excretor's death were respiratory failure (29%), hemoptysis (28%), general weakness (20%), acute aggravation (18%) and others (5%).
4. Wide cavitary lesion war an indication of the poorest prognosis. Advanced age, massive excretion, small vital capacity (less than 40%), bacteriai resistance to RFP, pulmonary complication were the main factors to worsen the clinical course.抄録全体を表示PDF形式でダウンロード (1189K) -
マウスの臓器濃度および血中濃度の比較束村 道雄, 水野 松司, 外山 春雄1986 年 61 巻 9 号 p. 453-459
発行日: 1986/09/15
公開日: 2011/05/24
ジャーナル フリーIn vitro growth-inhibitory activities of three quinolones (ofloxacin, ciprofloxacin and norfloxacin) were compared against Mycobacterium tuberculosis, M. kansasii, M. avium complex, M. fortuitum, M. smegmatis, M. aurum, and M. phlei using the actual count method. The actual count method is a method measuring the minimal inhibitory concentration (or the resistance level) as the lowest concentration (or the highest cocnentration) on which small inocula consisting of 10 to 100 viable bacteria fail to grow (or can grow).
The results showed that ofloxacin and ciprofloxacin are almost equally activie against the mycobacteria tested, but the activity of norfloxacin is 2 to 8 times lower than the former two. Ofloxacin tended to be more effective against most virulent Mycobacterium, M. tuberculosis, whereas ciprofloxacin tended to be somewhat more effective against nonpathogenic mycobacteria such as M. phlei and M. aurum.
The organ concentrations and the blood concentrations of these agents in mice were compared after intraperitoneal injection of 1mg. The highest concentrations were obtained in norfloxacin, and secondly in ofloxacin. Ciprofloxacin showed the lowest levels.抄録全体を表示PDF形式でダウンロード (881K) -
豊田 丈夫, 本間 聡起, 加茂 隆, 味澤 篤, 尾仲 章男, 河合 健1986 年 61 巻 9 号 p. 461-465
発行日: 1986/09/15
公開日: 2011/05/24
ジャーナル フリーA 39 years old man who had been suffering from SLE for 16 years was admitted to the Keio University Hospital because of renal dysfunction. Plain X-ray and CT of the abdomen on admission revealed splenomegaly with multiple small calcifications. Most of the calcified nodules were 1-3 mm in diameter and irregular in shape. While his renal dysfunction was ameliorated by pulse therapy with methylprednisolone, he developed pulmonary tuberculosis along with subcutaneous abscess on the left side of his back. Tubercle bacilli were positive in sputum and pus of subcutaneous lesions. The tuberculous lesions followed to corticosteroid administration might be construed as a flare up of the latent infection with tubercle bacilli that had been disseminated in these tissues. Multiple small splenic calcifications are occasionally seen in abdominal radiographs and it is thought that the majority of them are due to tuberculosis or phlebolith. Phlebolith is reported to be common in people over the age of 50 years and usnally round in shape. In this case, flare up of tuberculosis, his age and shape of the calcifications led us to a conclusion that the calcifications of the spleen is due to tuberculosis.抄録全体を表示PDF形式でダウンロード (7007K) -
安藤 正幸1986 年 61 巻 9 号 p. 467-487
発行日: 1986/09/15
公開日: 2011/05/24
ジャーナル フリーPDF形式でダウンロード (2577K)
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