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Volume 63, Issue 8
Displaying 1-7 of 7 articles from this issue
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I.Enumeration of Lymphocyte Subsets in the Peripheral Blood.Yasuko HARADA, Susumu HARADA, Masahiro TAKAMOTO, Yoshinari KITAHARA, T ...1988 Volume 63 Issue 8 Pages 555-561
Published: August 15, 1988
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSThe present study was undertaken to enumerate the proportion and absolute number of various lymphocyte subsets in the peripheral blood of 18 patients infected with atypical mycobacteria (AM). Those of age-atched 54 normal controls and 17 chronic excreters (chronics) with tuberculosis were also studied.
The results obtained were as follows:
1) The size of tuberculin reaction to PPD-s in patients with AM was significantly lower than that in chronics.
2) In AM, we found a significant decrease in the number of total lymphocytes, pan T cells (Leu4+), helper/inducer T cells (Leu3+) and inducer T cells (Leu 3+ 8+) compared to normal controls.There was also a decrease in the proportion of inducer T cells in AM.
2) In AM, we found a significant decrease in the number of total lymphocytes, pan Tcells (Leu4+), helper/inducer T cells (Leu3+) and inducer T cells (Leu 3+ 8+) compared to normal controls.There was also a decrease in the proportion of inducer T cells in AM.
In chronics, a similar decrease in total lymphocytes, pan T cells and helper/inducer Tcells was not significant compared to normal controls.However, we found a significant increase in the proportion of suppressor/cytotoxic T cells (Leu 2+) in chronics.The ratio of T4/T8 cells was slightly low in both groups as compared to normal controls.There was also an increase in the proportion of activated T cells (Leu 4+ DR +) in AM.The number of B cells (Leu 4+ DR+) tended to be decreased in both groups as compared to controls.
3) Among the natural killer cell subsets, we observed a significant increase in the proportion of Leu 7+ cells, Leu 11+ cells, Leu 11+7- cells and Leu 7+2+ cells in AM.
In chronics, there was an increase in the proportion of Leu 7+2+ cells.
These findings suggest that a decrease in circulating T-ymphocyte subsets may play a role in the pathogenesis of pulmonary infection with AM.View full abstractDownload PDF (843K) -
Michio TSUKAMURA1988 Volume 63 Issue 8 Pages 563-568
Published: August 15, 1988
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSThe multiple drug-resistance of Mycobacterium avium complex strains which were not exposed to antituberculosis drugs was compared with that of Mycobacterium fortuitum and Mycobacterium chelonae strains which were also not exposed previously to antituberculosis drugs.The number of strains in this study were 55, 20 and 20, respectively, and the Ogawaegg medium was used in the drug susceptibility testings.
The distribution curves of minimal inhibitory concentrations of rifampicin, minocycline and kitasamycin for the M.avium complex strains were bimodal and the strains were divided into two groups, one naturally highly resistant and another relatively susceptible. The susceptibility to rifampicin was correlated to the susceptibility to minocycline and to the susceptibility to kitasamycin (Tables 1 and 2).The susceptibility of the naturally resistant group of the M.avium complex strains to rifampicin, minocycline and kitasamycin were almost similar to the susceptibility of M.fortuitum and M.chelonae strains to these drugs.
M.fortuitum and M.chelonae strains were more resistant than M.avium complex strains in respect to the susceptibility to most drugs except ethionamide.
The susceptibility to rifampicin of the susceptible group of the M.avium complex was almost equal to that of Mycobacterium tuberculosis strains.This finding suggests that rifampicin may be useful in the treatment of infection due to rifampicin-susceptible strains of the M.avium complex.Furthermore, it was shown also that the susceptibilities to enviomycin and kanamycin of the M.avium complex strains are not so markedly different from those of M.tuberculosis strains.This suggests that these drugs may, to some extent, be useful in the treatment.View full abstractDownload PDF (609K) -
Yoshiro MOCHIZUKI, Takekuni IWATA, Kazukiyo OIDA, Yoshiaki KORI, Yoshi ...1988 Volume 63 Issue 8 Pages 569-575
Published: August 15, 1988
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSPulmonary lesions of tuberculosis were detected in 11 out of 1183 autopsy cases at Tenri Yorozu Hospital from 1978 to 1985.In all 11 cases, tuberculosis had occurred in the course of various underlying diseases such as lung cancer (3 patients) and malignant lymphoma (3 patients.) The results of clinical evaluation of the present cases were as follows:
1.Many patients had generalized tuberculosis dissemination in many organs.
2.Rapid progressive pulmonary tuberculosis may occur in compromised patients.
3.Repeated sputum examinations are needed for earlier diagnosis of pulmonary tuber culosis.
4.All physicians should keep in mind the possible incidence of tuberculosis in compromised patients.View full abstractDownload PDF (3720K) -
2.Infections Caused by M.marinumMichio TSUKAMURA1988 Volume 63 Issue 8 Pages 577-580
Published: August 15, 1988
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSThe infection of humans caused by M.marinum (M.balnei) was first reported by Norden and Linell in 1951-1954 as swimming pool-granuloma.Thereafter, the infection ofmen who worked with washing of fish tanks was also reported (fish tank granuloma).The causative organism probably lives in sea water and the infection to humans seems to occur through sea water or fishes.The principal lesion is granuloma in the skin of the hand, finger, elbow and/or knee.There is no report of infection of internal organs.Chemothera peutic agents reported as useful are minocycline, rifampicin, ethambutol, amikacin, etc.In this country, there are about 100 cases reported since 1970.View full abstractDownload PDF (510K) -
Takashi ITO, Fumio YAMAGISHI, Kiminori SUZUKI, Noriko MURAKI, Shoichi ...1988 Volume 63 Issue 8 Pages 581-585
Published: August 15, 1988
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSA Report was made on 3 cases developed pyrexia due to anti-uberculous drugs.
First case was a male aged 23 and diagnosed as miliary tuberculosis complicated with acute respiratory failure.Pyrexia occurred on the 14th day of drug administration. Rifampicin positivity was found at lymphocyte stimulating test, and as a result of discontinuing the administration, the fever was broken.
Second case was a male aged 22 and diagnosed as pulmonary tuberculosis complicated with dyspnea.Pyrexia occurred on the 24th day of drug administration.Streptomycin positivity was seen at lymphocyte stimulating test.
Third case was a male aged 22 and diagnosed as pulmonary tuberculosis.As a result of changing chemotherapy regimen to that containing PAS at 3 months after starting therapy, pyrexia occurred on the 13th day after changing the regimen.The fever was alleviated by discontinuing the administration only PAS.View full abstractDownload PDF (3772K) -
Shigenobu UMEKI, Niro OKIMOTO, Yoshito HARA1988 Volume 63 Issue 8 Pages 587-591
Published: August 15, 1988
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSA 55-year-old man was admitted because of productive cough and anorexia of 1-month's duration and a positive sputum smear of Mycobacterium tuberculosis.Since positive sputum smears continued even after 18-months' chemotherapy with isoniazidglucronate, ethambutol and enviomycin, the patient received lobectomy of the right upper and middle lobes.One month later a bronchothoracic fistula suddenly appeared.Despite twice surgical treatments against the fistula, it did not disappear.A chest roentgenogram revealed suprahepatic interposition of the colon, when the patient had complained of anorexia, abdominal pain and abdominal distension three years and half after the formation of bronchothoracic fistula.Then a diagnosis of Chilaiditi's syndrome was made.This case suggested that Chilaiditi's syndrome may occur due to the reduction of volume of the right thorax and lower lobe and changes in intrapulmonary pressure.View full abstractDownload PDF (4059K) -
[in Japanese]1988 Volume 63 Issue 8 Pages 595-596
Published: August 15, 1988
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSDownload PDF (247K)
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