巻号一覧
64 巻, 7 号
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束村 道雄1989 年 64 巻 7 号 p. 453-458
発行日: 1989/07/15
公開日: 2011/05/24
ジャーナル フリーIn vitro susceptibility testing of various mycobacteria (a total of 295 strains) to rifampicin was carried out using Ogawa egg medium and inoculation of 0.02 ml-samples from 10 mg wet weight per ml suspensions, which were preapred from 10 day-old cultures (M. tuberculosis, 21 day-old cultures; M. fortuitum, 3 day-old cultures).The minimal inhibitory concentration (MIC) was determined after incubation at 37°C for 14 days (M. tuberculosis and M. xenopi 21 days and M. fortuitum 5 days).MIC of M. tuberculosis strains, which were isolated from patients who were untreated previously by any antituberculosis drugs, was in the range of 3.13 to 12.5, ug/ml, thus the critical concentration of rifampicin, in which the clinical efficacy of rifampicin could be expected, was determined as 12.5, ug/m l. The percentage of strains of each species which are susceptible to this critical concentration is shown in Table 1.In M. avium complex strains, 50% of the strains were inhibited by rifampicin equal to or lower than the critical concentration.However, it is considered to be difficult to cure the disease completely even in these cases, because of the lack of other effective combination drugs with rifampicin. Monotherapy with rifampicin or that with less effective combined drugs would result in development of rifampicin-resistant population and failure of treatment. In successive studies, we will try to find out best possible combination drugs. From this study, the highest efficacy of rifampicin treatment was expected in the disease due to M. kansasii and the lowest efficacy in the disease caused by M. fortuitum.抄録全体を表示PDF形式でダウンロード (664K) -
佐藤 勝昌, 斎藤 肇, 副島 林造, 安達 倫文, 山村 好弘, 平田 義徳, 藤沢 和明, 林 勝文, 石川 兵衛, 久世 彰彦1989 年 64 巻 7 号 p. 459-463
発行日: 1989/07/15
公開日: 2011/05/24
ジャーナル フリーSix mycobacterial strains which were isolated and identified with some suspicions in five hospitals in Japan were retested for their biological and biochemical characteristics for correct identification at the Department of Microbiology and Immunology, Shimane Medical University.One strain originally classified as Group IV Mycobacterium, and two unidentified strains were presently identified as Mycobacterium nonchromogenicum complex.Two strains originally identified as M. xenopi were identified by us as M. szulgai and M. avium complex, respectively.Finally, one strain originally identified as M. phlei was identified by us as M. fortuitum.In these cases, inexactly controlled examinations for growth rate, growth at 45°C, Tween 80 hydrolysis, and pigment production or lack of tests for certain key characters of a given organism seemed to be main causes of initial incorrect identification.抄録全体を表示PDF形式でダウンロード (536K) -
肺結核の治療をうけていた肺癌症例佐藤 博, 萱場 圭一, 大泉 耕太郎, 本宮 雅吉1989 年 64 巻 7 号 p. 465-469
発行日: 1989/07/15
公開日: 2011/05/24
ジャーナル フリーOut of 939 primary lung cancer cases (histologically confirmed), 54 cases had received treatment with anti-tuberculous drugs before diagnosis of lung cancer was made. Fifty-one percent of the cases were detected by the mass survey and 55.6% of them were adenocarcinoma.
The duration of treatment for tuberculosis was less than 3 months in 63.0% and more than 13 months in 5.6% of the cases.
Surgery for lung cancer was performed in 25 cases (46.3%).The ratio of surgical intervention for patients previously treated with anti-tuberculous drugs was not different from that for patients who had received no anti-tuberculous drugs.抄録全体を表示PDF形式でダウンロード (608K) -
冨岡 治明, 斎藤 肇山, 田義 貴地, 土井 嚢璽1989 年 64 巻 7 号 p. 471-474
発行日: 1989/07/15
公開日: 2011/05/24
ジャーナル フリーEffect of aging on the mode of Mycobacterium intracellulare infection was examined using female ddy strain mice of 6, 12, 24, 48, 64 and 80 weeks old.When mice were infected intravenously with M.intracellulare 31F093 (8×107) and the incidence and the degree of gross lesions in the lungs and viable number of the organisms in the lungs and spleen were studied at 8 weeks after bacterial challenge, there was no marked difference in the grade of pathological lesions by age.However, all the mice younger than 25-weeks of age survived over the period of 8 weeks after infection, whereas about 30% of mice older than 48-weeks of age died during the course of infection.Thus, it is thought that some parts of old mice were more susceptible to M.intracellulare infection than young mice on the basis of their survival.抄録全体を表示PDF形式でダウンロード (399K) -
横内 裕佳1989 年 64 巻 7 号 p. 475-477
発行日: 1989/07/15
公開日: 2011/05/24
ジャーナル フリーThe auther experienced two model cases of long-lasting SPCN (smear positive and culture negative) status.The both cases having no prior chemotherapy, which were suggestive of relationship of SPCN to the use of RFP and the presence of huge cavity wherein tuberculous bacilli were most abundant.
In these two cases, the laboratory examination showed resistance of the bacillus against INH which was most effective in tuberculous chemotherapy and the bacillus were sensitive against RFP.The SPCN continued for more than half a year.The both cases had huge cavity in the lung.The culture of bacillus was continued for 16 weeks, and no growth of colony was observed. Moreover, in one case, RFP was prescribed 1.2g/day, much higher than the ordinary dose.The case was a medical doctor, and this dose was prescribed according to his wish.
As mentioned above, these two SPCN cases were very suggestive of the model of explaining mechanisms of SPCN with simultaneous presence of huge cavity, resistance against INH and sensitivity to RFP.抄録全体を表示PDF形式でダウンロード (2635K) -
梅木 茂宣, 玉井 仁, 沖本 二郎, 矢木 晋, 副島 林造1989 年 64 巻 7 号 p. 479-483
発行日: 1989/07/15
公開日: 2011/05/24
ジャーナル フリーA 61-year-old man was admitted to our hospital because of persisting cough, sputum and shortness of breath for four months. Brushing specimens and BALF bronchoscopically obtained revealed acid-fast bacilli and TBLB showed pathological findings consistent with interstitial pneumonia.Based on these results, clinical symptoms, chest roentgenograms on admission and identification of M.hansasii, a diagnosis of M. hansasii lung infection occurred in idiopathic pulmonary fibrosis was made. The patient's symptoms consistent with M.hansasii lung infection and his sputum became negative 6 weeks after antituberculosis chemotherapy with INH, SM and RFP.Because of an increasing dyspnea due to pulmonary fibrosis, however, the patient received oxygen therapy. This case suggested an increasing tendency of compromised hosts associated with M. hansasii lung infection.抄録全体を表示PDF形式でダウンロード (3498K) -
厚生省保健医療局結核・感染症対策室編1989 年 64 巻 7 号 p. 485-486
発行日: 1989/07/15
公開日: 2011/05/24
ジャーナル フリーPDF形式でダウンロード (241K)
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