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Volume 65, Issue 6
Displaying 1-7 of 7 articles from this issue
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A. A. Hafiez, M. A. Abdel-Hafez, M. EL-Khashab, Abdou M. A., A. A. Al- ...1990 Volume 65 Issue 6 Pages 391-395
Published: June 15, 1990
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSOral calcium tolerance test was done for 17 normal subjects and 26 pulmonary tuberculous patients.Ingestion of 1 gm calcium did not alter serum calcium levels significantly, while urinary calcium significantly increased in normal controls (p<0.001) and significantly decreased in tuberculous patients.
The decrease in urinary calcium in untreated TB patients may be attributed to the associated decrease in serum concentration of 25-hydroxyvitamin D.Serum PTH and nephrogenous cAMP showed insignificant changes both in controls and TB patients. Meanwhile, these changes are antiparallel to serum calcium, denoting a normal response (function) of parathyroid gland to serum calcium alterations.View full abstractDownload PDF (480K) -
Toshihiro SHIRAI, Atsuhiko SATO, Kingo CHIDA, Masami TANIGUCHI, Koji N ...1990 Volume 65 Issue 6 Pages 397-405
Published: June 15, 1990
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSTo clarify the clinical features of fatal cases of active pulmonary tuberculosis, patients with sputum positive for tubercle bacilli on admission were examined retrospectively. They were divided into two groups, those who died of tuberculosis (Group I), and those who died of non-tuberculous diseases (Group II).The mean age of all the patients was 74.8 years, and the male: female ratio was 7: 3.In Group I (n=26), the direct causes of death were respiratory failure (35%), general weakness (27%) and acute progression of tuberculosis (31%), and in Group II (n=10), about half of the patients died neoplasms.In addition, a control group (Group III) (n=27) of patients matched for age and sex with Group I, was examined.They were tuberculous patients who had improved and were subsequently discharged after chemotherapy.Compared with Group III, more patients in Group I showed poor oral feeding and had been bedridden on admission.Their nutritional status was significantly poorer, based on determination of total serum protein, alubumin, total serum cholesterol, and hemoglobin.With respect to cell-mediated immunity, Group I patients showed significantly lower peripheral lymphocyte counts and a reduced PPD skin reaction. However, the disease was more serious in Group I than the control.It was suggested that patients subsequently died of active pulmonary tuberculosis showed not only serious illness, but also malnutrition and depressed cell-mediated immunity.View full abstractDownload PDF (982K) -
Kazumasa YASUDA, Atsuhiko SATO, Kingo CHIDA, Izumi SHICHI, Hajime KISH ...1990 Volume 65 Issue 6 Pages 407-413
Published: June 15, 1990
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSA retrospective study of the hepatotoxicity of antituberculous drugs was undertaken to establish preventive measures for elevated transaminases by analyzing its clinical courses.Four hundred and forty six patients with normal liver function on admission were enrolled in this study.More than 50% of total 113 cases who showed abnormalities of transaminases were aggravated up to 4 th week after administration of drugs, and 80% up to 8 th week.The initial values of elevated transaminases did not relate to recovery rate, and could tolerate the additional administration of drugs.However, cases with higher peak values and excerbation in transaminases showed a tendency of delayed normalization.
These results indicate that the chronological observation of transaminases is useful to determine whether or not the antituberculous drugs should be discontinued when hepatic dysfunction occurs. Moreover, they suggest that patients with severe pulmonary tuberculosis may continue chemotherapy with the same regimen under careful observation of liver function even when their transaminase values exceed 100.View full abstractDownload PDF (743K) -
Masahiro SHIRAI, Atsuhiko SATO, Takafumi SUDA, Izumi SHICHI, Kazumasa ...1990 Volume 65 Issue 6 Pages 415-420
Published: June 15, 1990
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSTo investigate the role of Ca metabolism in granulomatous lung diseases, 187 patients with pulmonary tuberculosis42patients with sarcoidosis, and47patients with pneumonia were examind.
The mean value of serum Ca on admission in tuberculosis patients was significantly lower than in patients with sarcoidosis. Of 183 patients with tuberculosis, 69 patients (38%) showed Ca level lower than normal range.
The longitudinal observation of serum Ca level in 33 drug-responsive patients with tuberculosis disclosed that mean Ca level raised significantly at the third month of treatment, and maintain similar level up to the sixth month.
These findings suggest that the dynamics of Ca metabolism seen in tuberculosis was similar to that in pneumonia and differed from that in sarcoidosis, although both tuberculosis and sarcoidosis are characterized histologically by granuloma formation induced by cell-mediated immunity. To explain changes in Ca level, the chronological analysis of serum Vitamin D level was done, and it showed no correlation with serum Calevel.
The lower serum Ca level on admission and their normalization according to the improvement of clinical course in tuberculosis have not been reported yet.It seems that there are responsible factors other than Vit D for Ca level fluctuation, and further studies are needed.View full abstractDownload PDF (677K) -
Eriko MORISHITA, Shinji OZAWA, Takeshi KITAO1990 Volume 65 Issue 6 Pages 421-427
Published: June 15, 1990
Released on J-STAGE: August 23, 2011
JOURNAL FREE ACCESSA 68-year old male was referred to our hospital for the treatment of pulmonary tuberculosis.Chest X-ray film revealed left diffuse pleural thicking. Treatment of pulmonary tuberculosis was started with streptomycin, isoniazid and rifampicin Three months later, although smear and culture of the patient's sputum became negative for M.tuberculosis, he started to complain dyspnea on exercise and left chest pain.Biopsies of a pleural tumor and a left subclavicular lymphnode were done and a diagnosis of invasive thymoma with pleural dissemination and bone and lymphnode metastasis was established. After three cycles of combination chemotherapy consisting of cyclophosphamide, adriamycin and vincristine, left chest pain disappeared and pleural thicking showed shrinkage.View full abstractDownload PDF (3128K) -
K. Styblo1990 Volume 65 Issue 6 Pages 429-438
Published: June 15, 1990
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSDownload PDF (1078K) -
[in Japanese]1990 Volume 65 Issue 6 Pages 449-450
Published: June 15, 1990
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSDownload PDF (243K)
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