巻号一覧
65 巻, 7 号
選択された号の論文の8件中1～8を表示しています
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島村 喜久治1990 年 65 巻 7 号 p. 451-455
発行日: 1990/07/15
公開日: 2011/05/24
ジャーナル フリーDuring the 20th century, tuberculosis has been the most prevalent and most harmful disease in Japan. Enormous medical researches have ever been performed to conquer the disease. Nevertheless tuberculosis has left various somatic and psychological residues on vast convalescents. On the other hand, researches to conquer tuberculosis have made considerable contribution to other fields of medicine.
1. Somatic and psychological residues on convalescents from tuberculosis. Chest x-ray findings, cardio-pulmonary disturbance, secondary infection, serumhepatitis due to mass transfusion during the chest surgery, streptomycin-deafness and psychologicapsychological disorder.
2. Sequelae of phthisiology.
a. In the field of basic medicine. Respiratory physiology, immunology and genetic pharmacology.
b. In the field of epidemiology. Methodology to control the disease.
c. In the field of clinical medicine. Chest x-ray diagnostics, bronchoscopy, thoracoscopy, randomized controlled trial, regimens of chemotherapy, open chest surgery, anesthesiology, treatment of respiratory failure, informed consent, terminal care and cooperative study system.
d. In the field of rehabilitation. Medical, vocational and social rehabilitation of the handicapped.
e. In the field of public health. Comprehensive control system of the chronic disease.
Smallpox has been eradicated, but the elimination of tuberculosis is still far away. Studies as excellent as past ones should intensively be carried out.抄録全体を表示PDF形式でダウンロード (696K) -
三嘴 雄, 加藤 誠也, 浅川 三男, 鈴木 明, 立野 太刀雄1990 年 65 巻 7 号 p. 457-463
発行日: 1990/07/15
公開日: 2011/05/24
ジャーナル フリーThe incidence of active tuberculosis in Japan has markedly decreased in the past few decades. It is also reported that the prevalence of tuberculosis infection in young population has been decreasing in accordance with the decline in the overall occurrence of tuberculosis. The above mentioned facts indicate that the younger population has a greater risk of developing tuberculosis once exposed to tuberculosis infection. Actually, the epidemics of tuberculosis among the adolescent population have often been reported in recent years.
We performed a tuberculin skin test on our medical college students, who might be exposed to tuberculosis infection during their student clinical internship, in order to obtain the information about their present status of reaction to the tuberculin skin test.
The data obtained from students between 18 and 25 years old were analyzed using Student's t test and Kruskal-Wallis's method. The mean size of erythema in the group of 23, 24 and 25 years old were significantly greater than that in the group of 20, 21 and 22 years olds. Similarly the latter was significantly greater than that in the group of 18 and 19 years olds.Furthermore, it was proven by the Kruskal-Wallis's method that the older a group was, the greater the chance of a large erythema.抄録全体を表示PDF形式でダウンロード (780K) -
永田 忍彦, 瓦田 裕二, 高山 浩一, 重松 信昭, 石橋 凡雄1990 年 65 巻 7 号 p. 465-470
発行日: 1990/07/15
公開日: 2011/05/24
ジャーナル フリーTo determine whether or not patients who showed abundant lymphocytes in pleural effusion without any specific findings by pleural biopsy could be histopathologically differentiated between those with tuberculous and nontuberculous origin, we reexamined histology of pleural biopsies of all patients whose pleural effusion showed predominantly lymphocytes and did not contain malignant cells from January, 1984 to March, 1989. A total of 45 patients with a nonspecific histology of pleural biopsy were categorized based on their final diagnosis into three groups; tuberculous (n=20), carcinomatous (n=10) and nontuberculous, benign pleurisy (n=15). Pleural biopsy of patients with nontuberculous, benign pleurisy frequently showed band-like infiltration of mononuclear cells in the subpleural adipose tissue (11 out of 15 patients), while the finding was significantly less frequent in those with tuberculous pleurisy (1 out of 20, p<0.01) and pleurisy associated with carcinoma (3 out of 10, p<0.05). Based on these findings, the presence of band-like infiltration of mononuclear cells in the subpleural adipose tissue in pleural biopsy of patients with abundant lymphocytes in pleural effusion strongly suggests that the pleurisy is nontuberculous origin.抄録全体を表示PDF形式でダウンロード (1459K) -
束村 道雄1990 年 65 巻 7 号 p. 471-475
発行日: 1990/07/15
公開日: 2011/05/24
ジャーナル フリーThe determination of the susceptibilities to antituberculosis agents in Mycobacterium avium-Mycobacterium intracellulare complex (MAI complex) is influenced by the size of inoculation used in the determination. Such influences differ greatly according to the drugs. By increasing the number of colony-forming units (CFU) of the inoculation to 106-fold, minimal inhibitory concentrations (MICs) of rifampicin and cycloserine have increased only 2-to 3-fold. However, MICs of ethionamide, streptomycin, enviomycin and ethambutol have increased 4-to 9-fold. In contrast, MICs of isoniazid and sulfadimethoxine have increased 30-to 35-fold. Since the determination of MICs of isoniazid and sulfadimethoxine are so greatly influenced by the size of inoculation, the determinations of MICs of these two drugs should be carried out by use of the “actual count” method (6, 7, 9) or the proportion method (8). In the actual count method, the MIC is determined by inoculating 20-100 CFU.
The determination of isoniazid susceptibility of M. tuberculosis (H37Rv) was influenced only slightly by the size of inoculation, but that of M. bovis (BCG) was influenced greatly as occurred in the determination of MAI complex strains.抄録全体を表示PDF形式でダウンロード (550K) -
井田 隆, 谷合 哲, 新田 政男, 嶋瀬 順二, 巻口 宏平, 宮里 逸郎, 千田 守, 品田 秀穂, 篠原 陽子, 館 治彦, 丸茂 文 ...1990 年 65 巻 7 号 p. 477-481
発行日: 1990/07/15
公開日: 2011/05/24
ジャーナル フリーTo clarify the immunological aspect of tuberculosis, we investigated serum adenosine deaminase (ADA) activity, T and B cell percentile in total peripheral mononuclear cells, peripheral T cell subpopulation and their relationship with other inflammatory parametors in 20 patients with active pulmonary tuberculosis.
Serum ADA activity showed abnormal high level in all patients in nontreated phase with significant regression after three months treatment by anti-tuberculous drugs (P<0.05). In addition, significant positive correlationship was observed between serum ADA activity and erythrocyte sedimentation rate at 1hour (r=0.56).
Concerning about peripheral T cell subpopulation studied by two colour flow cytometry with FITC-conjugated anti-CD4 and phycoerythrin-conjugated anti-HLA-DR antibody, there was positive correlationship between CD4 (-) HLA-DR (+) T cell and serum ADA activity (r=0.59) without any abnormal frequency of each T cell subpopulation. Additionally, after the treatment of pulmonary tuberculosis, significant increase of T cell percentile in total peripheral mononuclear cells were observed (P<0.005).
In conclusion, these results may suggest serum ADA activity could be a parametor of activity of pulmonary tuberculosis and reflect the function of activated suppressor/cytotoxic T cell.抄録全体を表示PDF形式でダウンロード (485K) -
妻鳥 元太郎, 林 浩二, 栗本 典昭, 鎌田 達, 赤川 高明1990 年 65 巻 7 号 p. 483-488
発行日: 1990/07/15
公開日: 2011/05/24
ジャーナル フリーAn operated case of M. fortuitum infection on the bronchiectatic lung was presented.
A 68-year-old female had had hemoptysis due to bronchiectasis since she was 44years of age. She had a history of pulmonary tuberculosis at the age of 58 and treated by antituberculosis drugs for a year.
She was referred to the National Sanatorium Hiroshima Hospital in March 1986 for surgical treatment, when M. fortuitum infection was found.
Lobectomy of the right middle lobe, right S6 Segmentectomy and partial resection of right S2 were performed on December 1st 1986.
After the operation, hemoptysis disappeared but M. fortuitum was still found in sputum. Chest X-ray examination revealed some new abnormal shadows.
When radical surgical treatment for secondary M. fortuitum pulmonary infection is considered careful attention should be given to its indications including the extent of resection and the predicted post-operative pulmonary function.抄録全体を表示PDF形式でダウンロード (1318K) -
花田 敬吾1990 年 65 巻 7 号 p. 489-492
発行日: 1990/07/15
公開日: 2011/05/24
ジャーナル フリーMycobacterium kansasii has a strong virulence as compared with those of “mycobacteria other than tubercle bacilli”. In this study, hemolytic activities of several strains of M. kansasii were investigated. Secretion of hemolytic factor from these strains was not observed, since no hemolytic zone was found around the colonies grown on the 7H11 agar plate when 5% rabbit blood agar was overlayed. On the other hand, weak hemolytic activities were detected after treatment of sonication and trypsin-digestion of M. kansasii cells. They were also heat-resistant. These results indicate that endogenous nonproteinaceous factor was involved in the hemolytic activity of M. kansasii. Moreover, these activities were not species-specific in respect to the kind of target erythrocytes used for the assay. However, hemolytic activity of M. kansasii was not increased in spite of the change of culture conditions or supplement of nutrients into the medium.It is unlikely that this hemolytic activity is directly associated with a pathogenesis of M.kansasii, but detailed studies were needed to clarify on this point.抄録全体を表示PDF形式でダウンロード (362K) -
厚生省保健医療局結核感染症対策室編1990 年 65 巻 7 号 p. 493-494
発行日: 1990/07/15
公開日: 2011/05/24
ジャーナル フリーPDF形式でダウンロード (245K)
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