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Volume 65, Issue 9
Displaying 1-7 of 7 articles from this issue
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ESPECIALLY ABOUT ITS ONSET AND DURATIONHiroshi YAMADA, Akira YASUOKA, Kazuo SASAYAMA, Yasumasa DOUTSU, Toshia ...1990 Volume 65 Issue 9 Pages 563-568
Published: September 15, 1990
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSWe examined the adverse reactions of the antituberculous agents in 225 hospitalized patients (150: male, 75: female, average age: 45.4 years old) and the results were summarized as follows: 1) The side effects were seen in 53 patients (23.6%), and the abnormal laboratory findings were observed in 94 patients (41.8%).2) The incidence of adverse reactions in patients treated with three drugs (INH, RFP, EB) and four drugs (plus SM) were 45.9% and 82.4%, respectively.3) Adverse reaction appeared within one month after starting treatment in 67.9% of eligible patients, and it dissappeared within one month from its onset in 76.8% of patients.There results suggested the importance of careful clinical observation especially soon after starting antituberculous therapy.View full abstractDownload PDF (740K) -
Masahiro NAKAMURA, Yumiko HARANO, Toshihiko KOGA1990 Volume 65 Issue 9 Pages 569-574
Published: September 15, 1990
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSDuring the course of clinical examination of drug sensitivity tests for M.tuberculosis, a strain of M.tuberculosis which is considered to be rifampicin-dependent was isolated from a patient with persisting smear positive, culture negative (SPCN) or culture difficult (SPCD) mycobacteria status.The strain isolated produced a few tiny colonies on the control Ogawa-egg yolk medium, whereas it showed abundant growth like a bacteria plaque on the medium containing rifampicin 50μg/ml.
Furthermore, the growth of the strain on Ogawa medium containing rifampicin 50 μg/ml is much better than that on the medium containing rifampicin 10μg/ml.View full abstractDownload PDF (1966K) -
Yuji KAWARADA, Nobuhiko NAGATA, Koichi TAKAYAMA, Nobuaki SHIGEMATSU, T ...1990 Volume 65 Issue 9 Pages 575-579
Published: September 15, 1990
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSWe examined the significance of pleural fluid cytology in differentiation between tuberculous and non-tuberculous pleurisy in patients with lymphocyte-predominant pleural effusion.We divided pleural fluid cytologic findings into two patterns, that is“tuberculous” and“non-tuberculous pattern”, according to the report by Spieler, and compared the cytologic pattern with the final clinical diagnosis.Thirteen out of 19 cases (68.4%) with tuberculous pleurisy showed“tuberculous pattern”in the pleural fluid cytology, while four (pleurisy associated with collagen-vascular disease, asbestosis and carcinoma, and idiopathic pleurisy) out of 13 (30.8%) with non-tuberculous pleurisy revealed“tuberculous pattern”.The pleural fluid cytology could be used as one of the additional means to differentiate between tuberculous and non-tuberculous pleurisy, though it is impossible to differentiate between them with the pleural fluid cytology alone.View full abstractDownload PDF (3512K) -
I.Suppression of Delayed-type HypersensitivityReiko M. NAKAMURA, Yoshitaka GOTO, Masamichi KINOMOTO1990 Volume 65 Issue 9 Pages 581-584
Published: September 15, 1990
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSMycobacterium avium Mino grows well in the lung, spleen or liver of susceptible mice, such as C57BL/6, C57BL/10, and B10 congenics.Infection with Mino inhibited the induction of delayed-type hypersensitivity (DTH) to BCG in the mouse receiving subcutaneous injection of BCG 2 weeks later.Post-infection with Mino did not affect DTH to BCG already established.Preceding infection with avirulent strains of atypical mycobacteria weakly suppressed the induction of DTH by BCG.On the other hand, Mino infection did not affect DTH to SRBC.DTH to Mino and DTH to BCG detected by PPD-I and PPDs hardly showed cross-reactivity.These results suggest that tuberculin skin reaction after BCG vaccination could be suppressed by the infection with atypical mycobacteria in humans, especially where these bacterial infections are prevailing.View full abstractDownload PDF (518K) -
Yoshihiro KOBASHI, Makoto KIMURA, Junichi NAKAMURA, Tatsutoshi YANO, M ...1990 Volume 65 Issue 9 Pages 585-590
Published: September 15, 1990
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSIndex case is a 17-year-old boy who was admitted to our hospital with pleurisy and a minimal pulmonary lesion, and tubercle bacilli were recovered from pleural fluid.A diagnosis of primary tuberculosis was made based on the onset by pleurisy and the existence of hilar and mediastinal lymph node swelling.
On the same day, a 76-year-old man, grandfather of the index case was admitted for precise examination of suspected extensive pneumonia.Tubercle bacilli were also isolated from the pus of infected bulla obtained by puncture.Neither of these two cases, however, seemed to be the source of the familial tuberculous infection because of such sudden onset of the disease as pleurisy and pneumonia.
Two months later, a 46-year-old man, father of the index case was examined at our hospital.He was considered to be the source of the familial infection because he was diagnosed as tuberculosis with positive smear and a thick wall cavity (3.2 cm in diameter) on the left apex, and abnormal shadow was detected on his chest X-yay already two years ago.
The fourth case was a mother of the index case, and wife of the third case, whose chest rentogenogram revealed an infiltrative shadow on the right apex by a family contacts examination.
Though tubercle bacilli were not isolated from her sputum, pulmonary lesions considered to be tuberculosis due to their typical location and nature, a positive PPD skin test, and the response to antituberculous drugs.View full abstractDownload PDF (4958K) -
Izuo TSUYUGUCHI1990 Volume 65 Issue 9 Pages 591-601
Published: September 15, 1990
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSThe standard tuberculin skin test has been known as the prototype of delayed type hypersensitivity testing which is mediated by T cells and macrophages and plays animportant role in the pathogenesis of tuberculosis.Tuberculosis is indeed a chronic infectious disease, but variation in the host immune responses to tubercle bacilli results in the various clinical manifestations of the disease ranging from an immunologically hyperreactive state observed in pleural fluid lymphocytes in tuberculous pleurisy to an almost totally unresponsive state observed in those severely ill with refractory tuberculosis.
In tuberculous pleurisy, T cells in pleural fluid respond remarkably in vitro to PPD tuberculin whereas T cells in peripheral blood responded poorly to PPD stimulation. Compartmentalization of PPD-reactive T cells in the pleural fluid and immunosuppression by T cells and/or macrophages in the peripheral blood were responsible for this immunological difference observed between the lymphocytes in pleural fluid and those in peripheral blood of tuberculous pleurisy.
In advanced, drug-resistant tuberculosis as well as in nontuberculous mycobacterial infection, the proliferative responses of T cells in vitro to PPD stimulation were impaired. This depressed T cell response was due to depressed interleukin-2 (IL-2) production and not due to depressed IL-2 responsiveness.Therefore, the addition of exogenous IL-2, returned the depressed PPD-induced lymphocyte proliferation in vitro in these patients to the level of the response observed in lymphocytes from patients with newly-diagnosed tuberculosis.Our results suggest that recombinant IL-2 offers a novel approach to the therapy of advanced, drug-resistant tuberculosis and nontuberculous mycobacterial infection.Preliminary clinical trials of immunotherapy with recombinant IL-2 reveals the effectiveness of this therapy and encourages us to extend the trial to a larger scale.
Tubercle bacilli have various biological activities.Research on tuberculosis and tubercle bacilli have contributed much to the progress of biochemistry, pathology and immunology.Mycobacterium is a fascinating organism, which now presents another big appeal to those studying immunology: Study of immunological interaction between yd T cells and the highly conserved protein in mycobacteria, HSP, heat shock protein will contribute to the elucidation of the mechanism of immunological surveillance and the mechanism of autoimmune diseases.In addition, it will also contribute to the development of a new mycobacterial vaccine which will give direct, protective immunity against tuberculosis.View full abstractDownload PDF (1395K) -
[in Japanese]1990 Volume 65 Issue 9 Pages 607-608
Published: September 15, 1990
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSDownload PDF (258K)
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