巻号一覧
66 巻, 2 号
選択された号の論文の7件中1～7を表示しています
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第1報: 臨床像の変化と発症機序に関する考察尾形 英雄, 岩井 和郎1991 年 66 巻 2 号 p. 67-74
発行日: 1991/02/15
公開日: 2011/05/24
ジャーナル フリーForty-eight cases of tuberculous hilar lymphadenopathy were studied comparatively between the groups experienced before and after 1975.We found the following characteristics in the clinical manifestations and in the mode of onset among the recent cases as against the classical ones.
(1) Age distribution of cases shifted from younger to elderly groups.
(2) Rentgenologically, typical primary complex has been decreasing, while the atypical patterns such as solitary mediastinal lymphadenopathy or those associated with healed pulmonary lesions have increased.
(3) Since the introduction of RFP to the treatment of tuberculosis, cases of hilar lymphadenopathy incidentally diagnosed with the early exacerbation due to RFP has been increasing.
(4) Of the total of 48 cases, 10 were presumed not being originated, from the primary infection, but from reactivation.
(5) Relative increase of such cases may partly explain the shift of hilar lymphadenopathy to elderly group.抄録全体を表示PDF形式でダウンロード (3075K) -
束村 道雄1991 年 66 巻 2 号 p. 75-79
発行日: 1991/02/15
公開日: 2011/05/24
ジャーナル フリーIn 0.1% Tween 80 aqueous solution or in 0.1% Tween 80-containing saline (0.9% NaCl aqueous solution), Mycobacterium smegmatis strain Jucho bacteria were alive for 3 days, whereas, in 0.1% Tween 80-containing phosphate buffer solution (pH 7.1), the bacteria died rapidly. Since it was shown previously that M. smegmatis is one of the mycobacteria most susceptible to Tween 80 (Tsukamura, M: Kekkaku 63: 695-699, 1988), the 0.1% Tween 80 aqueous solution or 0.1% Tween 80-containing saline may be used for suspending mycobacteria in order to prevent the clumping. Incorporation of 32P-ortho-phosphate to the nucleic acid fraction was most markedly inhibited by the presence of 0.5% Tween 80 in 0.067 M phosphate buffer solution (pH 7.1). The finding shows that Tween 80 inhibits directly or indirectly the synthesis of nucleic acids.Tween 80 was not bactericidal in an aqueous solution but acted bactericidally in the co-existence of phosphate, and such bactericidal activity was completely diminished by adding an ammoniacal nitrogen compound (Tsukamura, M.: Medicine and Biology (Tokyo) 96: 159-161, 1978). These findings suggest that Tween 80 does not simply act as a detergent but interferes with some metabolic way in the synthesis of nucleic acids.抄録全体を表示PDF形式でダウンロード (628K) -
高橋 義郎1991 年 66 巻 2 号 p. 81-85
発行日: 1991/02/15
公開日: 2011/05/24
ジャーナル フリーTubercle bacilli were injected intravenously to mice after dusts were injected into their subcutaneous tissue.Out of 23 kinds of dusts tested, a quartz dust enhanced most the growth of mycobacteria injected intravenously in mice.Based on this a mixture of the sputum from patients with pulmonary tuberculosis and finely powdered crystalline silica was inoculated subcutaneously into the flanks of mice.
Growth of tubercle bacilli was demonstrated occasionally for the sputum specimens from smear-positive and culture-negative cases, and even for smear-and culture negative cases. When a sputum specimen which yielded many, colonies on routine egg medium were tested, the growth of bacteria became visible as early as 2 weeks after inoculation.
On the other hand, it took 3 to 4 weeks for the visible growth of bacilli, when a sputum specimen yielded only a few or no colonies on culture medium.
In this method, the bacilli appeared earlier and more frequently than in the routine culture method on egg medium.
Thus an inoculation into mice with a mixture of the sputum and quartz powder was shown to be a sensitive method for the diagnosis of pulmonary tuberculosis.抄録全体を表示PDF形式でダウンロード (3621K) -
小橋 吉博, 安達 倫文, 木村 丹, 松島 敏春1991 年 66 巻 2 号 p. 87-93
発行日: 1991/02/15
公開日: 2011/05/24
ジャーナル フリーWe encountered two cases of infected primary complex in which a new intrapulmonary lesion appeared during antituberculous chemotherapy with RFP and INH. These were from 19 cases of tuberculous pleuritis which we treated in the past seven years. In the first case, the intrapulmonary lesion appeared 1 month after the initiation of antituberculous chemotherapy and disappeared at 4 months when the same chemotherapy was continued. In the second case, the lesion appeared 4 months after antituberculous chemotherapy was begun and disappeared at 13 months in the same manner. No particular abnormalities in clinical symptoms or laboratory findings were observed when the new intrapulmonary lesion appeared.In neither case had the lesion been hidden behind pleural effusion. The following causes were been thought to be responsible for the phenomenon rather than the so called initial reversible roentogenographic progression;In the first case, steroid therapy had been used for a short time, and in the other case, dose of antituberculous drugs had been reduced due to a drug allergy.抄録全体を表示PDF形式でダウンロード (6767K) -
国療化研第30次B研究報告螺良 英郎1991 年 66 巻 2 号 p. 95-99
発行日: 1991/02/15
公開日: 2011/05/24
ジャーナル フリーThe 445 cases of pulmonary tuberculosis in compromisd host were investigated. Summary of the analysed results were as follows
(1) The major underlying diseases of compromised hosts with tuberculosis were diabetes mellitus and various types of cancer.
(2) The major risk factors for advancement of tuberculosis were malnutrition and iatrogenic suppressions due to long term use of corticosteroids and anticancer agents.
(3) The patients with malnutrition in the compromised hosts showed poor prognosis.
(4) The chest roentgenogram of tuberculous lesion was difficult to improve in these patients when their clinical stage of tuberculosis had been advanced at admission.
(5) The diagnosis and management of pulmonary tuberculosis in compromised host remain as a serious problem in recent years.抄録全体を表示PDF形式でダウンロード (631K) -
力丸 徹, 川原 正士, 市川 洋一郎, 大泉 耕太郎, 中村 雅博1991 年 66 巻 2 号 p. 101-107
発行日: 1991/02/15
公開日: 2011/05/24
ジャーナル フリーWe reported three cases whose pleural tumorous shadows enlarged during the intensive chemotherapy for tuberculosis. The patients were 39 year-old female, 63 year-old female, and 22 year-old male.
Their chest X-ray films on admission showed pleural effusion or infiltration, but no tumorous shadows.Eight to 16 weeks after starting the antituberculous therapy with INH, RFP and SM, new tumorous shadows appeared in the right chest wall (case 1, 3) or the left chest wall (case 2). The mass extracted from case 1 contained granuloma with caseous nacrosis. The tumorous shadows on chest X-ray films in case 2 and 3 disappeared by continuous antituberculous therapy.
We can not definitely conclude that the disease of these 3 cases were same diseases to be called either percostal tuberculosis, peripleural abscess or peripleuritis tuberculosa as observed in case 1.
The phenomenon observed in case 2 and 3 is suspected to be caused by some allergic mechanism eg. Jarisch-Herxheimer reaction which is observed during the therapy for syphilis.抄録全体を表示PDF形式でダウンロード (5097K) -
厚生省保健医療局結核・感染症対策室編1991 年 66 巻 2 号 p. 121-122
発行日: 1991/02/15
公開日: 2011/05/24
ジャーナル フリーPDF形式でダウンロード (255K)
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