巻号一覧
68 巻, 11 号
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局木 健三, 渡辺 久芳, 古井 秀彦, 小川 賢二, 笹本 基秀1993 年 68 巻 11 号 p. 677-682
発行日: 1993/11/15
公開日: 2011/05/24
ジャーナル フリーWe previously reported the clinical role of plasma immunoreactive atrial natriuretic polypeptide (ANP) and cyclic GMP in patients with respiratory diseases, bronchial asthma (BA), chronic pulmonary emphysema (CPE) and pulmonary insufficiency induced by pulmonary tuberculosis (TBC). In this study, moreover, we divided patients with respiratory failure induced by tuberculosis sequelae into two groups, patients with oxygen therapy group {O2 (+) group} or ordinary practical treatment group {O2 (-) group}, and we evaluated the difference of the roles of ANP in two groups and the correlation of ANP and c-GMP with clinical findings, blood gas analysis, electrocardiogram, chest roentogen photography and spirogram in two groups.
In conclusion, the respiratory failure in patients with tuberculosis sequelae is compensated by increased cardiac output, and that causes the rising of right atrial pressure. These results show, addition to the basic effects of ANP, the concentration of plasma ANP is released with relating the degree of respiratory failure.抄録全体を表示PDF形式でダウンロード (886K) -
冨岡 治明, 佐藤 勝昌, 斎藤 肇, 出来尾 哲, 日高 隆義1993 年 68 巻 11 号 p. 683-686
発行日: 1993/11/15
公開日: 2011/05/24
ジャーナル フリーMice were infected intravenously with M. intracellulare (5.2X106 CFU/mouse) and then were given 0.4mg of KRM-1648 emulsified in 2.5% gum arabic-0.2% Tween 80 by gavage, once daily 1, 3 or 6 times per week, from 24h after infection to the end of experiment (week 8). Evaluation of the therapeutic efficacy of the drug against the infection was done on the basis of incidence and degree of gross lung lesions, organ weight (organ (mg) /body (g) ×10), and bacterial loads in the lungs and spleen. The lung lesions were not observed in all experimental groups at 4 weeks after infection. At 8 weeks after infection, the lung lesions observed in all control and solute (2.5%gum arabic-0.2% Tween 80) control mice, whereas 3 of the 5 mice given KRM-1648, 3 times per week and all of 5 mice given KRM-1648, 6 times per week showed no lung lesions. Although lung lesions were observed in all mice given KRM-1648 only once per week, the degree of the lesions was much more milder in KRM-1648-treated mice than in solute control mice. The spleen weight of solute control mice and KRM-treated mice differed from each other 4 and 8 weeks after infection, especially in mice administered 6 times per week. The CFUs of organisms in the lungs and spleen were lower in mice treated with the agent than in mice given solute at 4 and 8 weeks after infection, in orders of administration of 6, 3 and 1 times per week.抄録全体を表示PDF形式でダウンロード (525K) -
山崎 利雄, 中村 玲子1993 年 68 巻 11 号 p. 687-693
発行日: 1993/11/15
公開日: 2011/05/24
ジャーナル フリーPCR products amplified with the primers YNP-1 and YNP-2 and template DNA from various mycobacterial species showed differences in molecular sizes. By sequencing the PCR products, we found that the DNA fragment from M. tuberculosis and that of M. intracellulare have different DNA sequences. The former was 164 bp, composed of 27 A, 54 C, 57 G, and 26 T, while the latter was 109 bp, composed of 22 A, 37 C, 34 G, and 16 T. We compared these sequences and selected a nucleotide sequence unique to M. intracellulare and used as primer YNP-7. Antisense primer, YNP-8, was constructed from the complementary sequence of YNP-2 which is located about 270 b downstream of YNP-7. Results of PCR using the primers YNP-7 and YNP-8 and template DNA of various mycobacteria showed that positive results were only with the template DNA from M. intracellulare. Bacterial DNA from those other than mycobacteria but appear in sputum were tested in PCR with the primers YNP-7 and YNP-8. None of them showed positive results. Specificity of the PCR products was determined with a specific probe MIP which was constructed using a sequence between YNP-7 and YNP-8 to confirm the specificity of PCR by Southern hybridization. Only the products from M. intracellulare hybridized with the probe MIP, indicating the specificity of YNP-7 and YNP-8 to M. intracellulare. The PCR product amplified with YNP-7 and YNP-8 was sequenced and it was found that this product is 271 by in size, composed of 58 A, 87 C, 86 G, and 40 T. This study shows a possibility of species identification in mycobacteria by PCR.抄録全体を表示PDF形式でダウンロード (1871K) -
佐々木 結花, 山岸 文雄, 鈴木 公典, 宮澤 裕, 杉戸 一寿, 庵原 昭一1993 年 68 巻 11 号 p. 695-698
発行日: 1993/11/15
公開日: 2011/05/24
ジャーナル フリーWe reported a case of Addison's disease, caused by adrenal tuberculosis. The patient was female, seventy four years old. She complained cough and body weight loss. She complained cough from June, 1989, but her home doctor didn't take care of her symptoms. September 1989, she felt appetite loss, and easy fatigue, so her home doctor suspected her disease as pulmonary tuberculosis, so he introduced our hospital, and she admitted. When she admitted, her chest roentogenogram revealed bII12. Sputum smear examinations were negative. Laboratory datas on admission, we observed slightry eosinophilia, severe iron deficiency anemia, and accenturation of blood sedimentation rate. Immediately after admission, she complained nausea, vomiting, coldness, and powerless. On 25 days after admission, she lost her senses suddenly, and her blood pressure fell 5 days after, she fell in shock state, too. We found out her blood sugar data was 29. After blood examinations, we found out that ACTH was high, cortisole, 17KS, 17-OHCS were low. So we thought she got acute hypoadrenocorticism. We found her abdominal CT revealed calcification in her right adrenal gland. We diagnosed her disease as Addison's disease caused by adrenal tuberculosis so we began to give prednisolone, 7.5mg per day. After giving, her state made better. We thought her disease as Addison's disease caused by adrenal tuberculosis, revealed acute hypoadrenocorticism.抄録全体を表示PDF形式でダウンロード (2888K) -
1993 年 68 巻 11 号 p. 699-733
発行日: 1993/11/15
公開日: 2011/05/24
ジャーナル フリーPDF形式でダウンロード (7808K) -
厚生省保健医療局結核・感染症対策室1993 年 68 巻 11 号 p. 735-737
発行日: 1993/11/15
公開日: 2011/05/24
ジャーナル フリーPDF形式でダウンロード (358K)
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