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Volume 69, Issue 1
Displaying 1-7 of 7 articles from this issue
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Nobuyuki SUGIURA, Hiromitsu SAISHO, Akimitsu SHIMURA1994 Volume 69 Issue 1 Pages 1-5
Published: January 15, 1994
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSOf the patients diagnosed as having hepatocellular carcinoma (HCC) at Chiba University Hospital and affiliated hospitals from 1978 to 1992, 191 patients with histories of having a blood transfusion more than 10 years ago were studied. Histories of having transfusions for tuberculosis were the most common, being documented by 50 patients. Of those patients receiving transfusions for tuberculosis, the average period from transfusion to the detection of HCC was 31.1 years and the average year of transfusion was 1955. Liver dysfunction was found during routine medical examinations of the most patients (38.9%), and HCC was diagnosed in 17% of the patients soon after the detection of liver dysfunction. Of the HCC patients with histories of tuberculosis treatment, anti-hepatitis C virus was frequently tested positive regardless of a history of transfusion.
Patients with histories of transfusions for tuberculosis should continually be examined for liver dysfunction, and it must be considered that these patients have a risk of developing HCC.View full abstractDownload PDF (650K) -
Comparison between the MTD and the Test by Culture on Ogawa's Egg Medium or in the MB Check SystemTeruo AOYAGI, Takeo TOYODA, Mitsuhiko OSUMI, Kazushi KITAHARA, Shinkic ...1994 Volume 69 Issue 1 Pages 7-14
Published: January 15, 1994
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSThree or more weeks are usually required for detecting Mycobacterium tuberculosis by the known culture methods, and therefore, the development of a rapid bacteriological diagnostic method for M. tuberculosis has been urgently awaited. Recently, Gen-Probe Inc. has developed the “Gen-Probe Mycobacterium Tuberculosis Direct Test (MTD) ”, which is based on amplification of the ribosomal RNA (rRNA) of M. tuberculosis in clinical specimens and hybridization of the amplified rRNA with a M. tuberculosis-specific DNA probe, as a rapid direct diagnostic method for tuberculosis.
We therefore compared the sensitivity and specificity of the MTD in detecting M.tuberculosis with the culture methods on Ogawa's egg medium and in the MB Check System, using 107 clinical specimens as test material. The results obtained are as follows:
1. Of the 61 clinical specimens which were negative when cultured on Ogawa's egg medium, 13 (21.3 %) were positive for M. tuberculosis using the MTD, and of the 48 clinical specimens which were negative when cultured in the MB Check System, 8 specimens (16.7 %) were positive for M. tuberculosis using the MTD.
2. All of the specimens which yielded growth of M. tuberculosis (identified by the DNA probe) either on Ogawa's egg medium or in the MB Check System, except one, were positive for M. tuberculosis in the MTD. The only one exception was a specimen which was positive for M. tuberculosis in both Ogawa's medium and the MB Check System.
3. Of the 28 specimens which yielded growth of atypical mycobacteria (identified by the DNA probe) in cultures, 27 specimens were negative for M. tuberculosis in the MTD.
4. The specimens which were negative both on Ogawa's egg media and in the MB Check System but positive for M. tuberculosis in the MTD must have contained few tubercle bacilli, because the clinical status of the 6 patients from whom these specimens were taken suggested that their tuberculosis was still active.
Based on these results, we concluded that the MTD is a very efficient method of direct detection of M. tuberculosis in clinical specimens and for the rapid diagnosis of tuberculosis.View full abstractDownload PDF (802K) -
Hiroshi MIYAZAWA, Kiminori SUZUKI, Fumio YAMAGISHI, Yuka SASAKI, Kazut ...1994 Volume 69 Issue 1 Pages 15-19
Published: January 15, 1994
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSThis report is a case study of miliary tuberculosis that was induced when adrenocor ticosteroid treatment for tuberculosis of the wrist was given because of a mistaken diagnosis of rheumatoid arthritis. An 85-year-old man was admitted to a hospital with a fever and chest pains. Since an examination of the chest X-ray revealed fine nodules throughout both lungs and a sputum smear tested positive for acid-fast bacilli, he was transferred to our hospital.
The patient had a three-year history of pain in his left wrist joint. He had swelling on the dorsal aspect of his left wrist for l1/2 years, and had been diagnosed as having rheumatoid arthritis. Predonisolone had been administered in dosages of 5 mg per day for two months and 5 mg every other day for four months prior to admission.
Upon admission to the hospital, an X-ray examination of the wrist revealed marked destruction of the left carpal bones. Smears of fluid aspirated from the swelling showed acid-fast bacilli, and cultures grew M. tuberculosis. He was treated with INH, RFP and SM, however, he had complications of tuberculous spondylitis and renal tuberculosis, and died nine months after admission.View full abstractDownload PDF (3993K) -
Yasuo MISHIMA, Makoto TAKEUCHI, Ken KAMISAKA, Chiharu OKADA, Atsuhiko ...1994 Volume 69 Issue 1 Pages 21-25
Published: January 15, 1994
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSA 34-year-old man was admitted to our hospital because of cough and fever. Chest radiograph showed multiple cavities mainly on the right lung. His sputum was positive for acid-fast bacilli on smear, and he was treated with daily isoniazide, rifampicin and streptomycin. Antituberculous treatment was successfully performed, so acid-fast bacilli of his sputa disappeared on smear and culture.
Five months later, he developed a purpuric lesin over both legs accompanied by low grade fever and arthralgia, but proteinuria and abdominal pain could not be observed. Laboratory findings showed a normal platelet count and a normal bleeding time. High levels of serum IgG, IgA, C3 and C4 were evident. ASLO and ASK titer were elevated and they markedly increased within two weeks. A direct invasion of the vessel wall by tubercle bacilli is deniable because antituberculous treatment was successfully continued. Henoch Schonlein purpura was diagnosed judging from these findings. High levels of ASLO and ASK suggest a preceeding streptococcal infection for developing purpura but a possible infectious focus could not be identified.
He was treated with 15 mg of prednisolone daily for two weeks and the lesion was subsided. The effect of prednisolone suggests that a subsequent antigen-antibody interaction caused by a streptococcal infection may participate in the formation of the purpura.View full abstractDownload PDF (3105K) -
Atsuro HASHIMOTO, Hironobu KOGA, Shigeru KOHNO, Yoshitsugu MIYAZAKI, K ...1994 Volume 69 Issue 1 Pages 27-30
Published: January 15, 1994
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSA 30-year-old female was admitted to our hospital for further investigation of infertility. The menstrual culture and polymerase chain reaction (PCR) of the endometrial tissue for detection of Mycobacterium tuberculosis were both positive. The pelvic CT scan and hysterosalpingography showed a slightly expanded uterus and irregularity of the endometrium. Barium enema and pyelography showed no abnormality. Since these data established a diagnosis of early primary endometrial tuberculosis, the combined therapy of three antituberculous agents was commenced. Menstrual smear, culture and PCR for M. tuberculosis were examined monthly throughout the therapy. The mycobacterial culture became negative soon after the start of therapy, followed by a negative PCR result 3 months later. We conclude that PCR is useful for the rapid detection of M. tuberculosis not only in pulmonary but also in endometrial tuberculosisView full abstractDownload PDF (2970K) -
Global Strategy and Role of JapanNobukatsu ISHIKAWA1994 Volume 69 Issue 1 Pages 31-53
Published: January 15, 1994
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSDownload PDF (3184K) -
[in Japanese]1994 Volume 69 Issue 1 Pages 55-57
Published: January 15, 1994
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSDownload PDF (348K)
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