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Volume 69, Issue 2
Displaying 1-7 of 7 articles from this issue
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Hajime SAITO, Haruaki TOMIOKA, Katsumasa SATO, Takayoshi HIDAKA1994 Volume 69 Issue 2 Pages 59-63
Published: February 15, 1994
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSTherapeutic efficacy of KRM-1648 was studied in BALB/c mice infected with Mycobacterium intracellulare. Mice were infected intravenously with 1.0-107 CFU of the organisms/mouse and then given 0.2 mg or 0.4 mg of KRM-1648 emulsified in 2.5% gum arabic-0.2%Tween 80 by gavage, once daily, 6 days per week, from day 1 to the death of mice. Thetherapeutic efficacy of the drug was evaluated on the basis of survival times, incidence anddegree of gross lung lesions and bacterial loads in the lungs and spleen. The lung lesionswere not observed in any experimental groups at 4 weeks after the infection. At 8 weeksafter the infection, the lung lesions were observed in all control mice, but 2 of 5 micetreated with 0.2 mg of KRM and 4 of 5 mice treated with 0.4 mg of KRM did not show anylung lesions, and the degree of the lesions was much milder in KRM-1648-treated mice thanin the control mice. All mice of treated and untreated groups died, and median survivaltimes were 141 days for the control mice, 216 days for mice treated with 0.2 mg of KRM1648 and 220 days for mice treated with 0.4 mg of KRM-1648. At the death, lung lesionswere observed in all mice. The CFUs of M. intracellulare in the lungs and spleen in micetreated with KRM-1648 were fewer than those in the control mice at 4 and 8 weeks afterthe infection. However, bacterial loads in the lungs of the dead mice treated with KRM1648 were larger than those of the control mice, and the CFUs in the spleen at the death ofmice given KRM-1648 were almost the same as those of the control mice. MICs of KRM1648 against the organisms isolated from the lungs and spleen at the death of mice were 0.05-0.1μg/ml. In this case, the MIC of KRM-1648 against the parent strain used for the infection (M. intracellulare N-256) was 0.05 -0.1μg/ml. Nevertheless, KRM-1648, which exhibited therapeutic efficacy against M. intracellulare at the early phase of infection, was not effective at the late phase of infection. Thus, this uneffectiveness of KRM-1648 on the later phase of M. intracellulare infection is not due to acquisition of resistance of the infected organisms to the agent.View full abstractDownload PDF (562K) -
Ichiro TERAO, Teruhisa HAGIWARA, Shingo IIJIMA, Takashi HAYAMA, Takash ...1994 Volume 69 Issue 2 Pages 65-69
Published: February 15, 1994
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSRecently, the annual reduction in the incidence rate of tuberculosis has slowed in Japan.One reason for this trend is believed to be due to an increase in the number of immunocompromised hosts. In our department, we discovered 10 cases of pulmonary tuberculosis among962 cases of collagenosis, and have analyzed the factors for the development of pulmonarytuberculosis in these patients. A total of 29 patients wer involved in the study: 22 withsystemic lupus erythematosus (SLE) (active disease, 10; inactive disease, 12) and having nopulmonary complications, and seven with pulmonary tuberculosis and no concomitantdiseases.
Our findings were as follows:
1. Seven of the 10 patients with pulmonary tuberculosis also suffered from SLE.
2. Nine of the 10 patients had been treated with a corticosteroid or immunosuppressant.
3. Serum CHSO and erythrocyte sedimentation rate (ESR) were valuable indicaters fordiagnosing pulmonary tuberculosis in the patients with SLE.
4. Patients with SLE and pulmonary tuberculosis tended to show lymphopenia inperipheral blood, which was further enhanced by prolonged use of steroids.
5. Miliary tuberculosis rather than pulmonary tuberculosis tended to develop inelderly patients, and required longer hospitalization.View full abstractDownload PDF (663K) -
Yoshiko ISHII, Takahiro YONEDA, Katsuhiko TSUKAGUCHI, Akihiro FU, Shoj ...1994 Volume 69 Issue 2 Pages 71-75
Published: February 15, 1994
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSA study was made on a patient with anorexia nervosa complicated with pulmonarytuberculosis treated with intravenous hyperalimentation (IVH).A 24-year-old female was admitted to our hospital because of progressive loss of bodyweight during medication for pulmonary tuberculosis at another hospital. She wasdiagnosed as having anorexia nervosa. After the nutritional assessment IVH was performed.As a result of IVH, her body weight increased and her nutritional deprivation, (i. e., lowvisceral proteins, low branched amino acids, etc.) recovered.Nutritional support was effective upon treating pulmonary tuberculosis.View full abstractDownload PDF (1306K) -
Haruhiko KAWAGUCHI, Yoshio TORII, Yoshihiro SENDA, Yasunobu TOTANI, Ma ...1994 Volume 69 Issue 2 Pages 77-82
Published: February 15, 1994
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSA case of generalized disseminated atypical mycobacteriosis caused by M. aviumcomplex (MAC) was reported. The case was a female of 52 years of age. She was admittedto our hospital due to high fever and polyarthralgia. Her chest X-ray and CT scan revealedinfiltrative shadows in the right 52b and S4 segments, and multiple accumulation shadowswere seen on osteoscintigraphy.
Pus aspirated from a lesion of the right fifth rib were acid-fast bacilli positive bysmear (Gaffky v). The administration of four drugs, INH, RFP, EB and SM, wasintroduced, then corticosteroid was added, and the case became afebrile. Later, acid-fastbacilli were also isolated from bronchial washing and aspirated specimen from bonemarrow, and all of them were identified as MAC. Based on these findings, the case wasdiagnosed as generalized disseminated mycobacteriosis.
After several months remission, tenderness over the fifth lumbar vertebra deteriorated, and MRI scan on lumbar vertebrae showed high-intensity area both on Tl-weighted and T2-weighted images. MAC was isolated from the pus of the fifth lumbar vertebra. Lumbarlesions deteriorated gradually, and a giant gravitation abscess which involved right iliumwas revealed by CT scan of the pelvis.View full abstractDownload PDF (1625K) -
Takuya KURASAWA, Nobuaki IKEDA, Hideyo YAMADORI, Atsuo SATO, Koichi NA ...1994 Volume 69 Issue 2 Pages 83-87
Published: February 15, 1994
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSThe report is a study of the cases in which elderly people (83 years-old male and 81years-old female) diagnosed has having acute tuberculous pneumonia possibly sufferedfrom subsequent perforation of lymph nodes in the bronchus. Neither of the patients had aprior history of tuberculosis treatment. Both patients were admitted to the hospital afterbeing diagnosed with pneumonia. After the administration of antibiotics, the symptoms ofillness improved, but chest roentgenograms were taken failed to show improvement. Thepatients were then transferred to our hospital, bacause sputa smear tests for Mycobacteria (Ziehl-Neelsen stain) were performed, and the results were positive.
Case I (male) was suspected of having endobronchial tuberculosis, since rhonchi wasaudible in the left-front upper chest during expiration when performing ausculation. Abronchoscopy was conducted at which time ulcer lesions on the left upper lobe of thebronchus and perforated lymph node of the upper bronchus were detected.
Case II (female) was suspected of having lung cancer and a bronchoscopy was performed due to the findings of a chest roentogenogram taken after one month of chemotherapy. A perforated lymph node in right truncus intermedius was detected.
In this report, we discussed the early diagnosis of tuberculous pneumonia and theperforation of caseous lymph nodes in the bronchus, which was the main cause oftuberculous pneumonia.View full abstractDownload PDF (1141K) -
1994 Volume 69 Issue 2 Pages 89-124
Published: February 15, 1994
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSDownload PDF (5004K) -
[in Japanese]1994 Volume 69 Issue 2 Pages 129-131
Published: February 15, 1994
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSDownload PDF (342K)
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