巻号一覧
69 巻, 5 号
選択された号の論文の8件中1～8を表示しています
- |<
- <
- 1
- >
- >|
-
鈴木 恒雄, 豊田 恵美子, 可部 順三郎1994 年 69 巻 5 号 p. 345-350
発行日: 1994/05/15
公開日: 2011/05/24
ジャーナル フリーWe have investigated on the clinical features of pleural nodular lesions which haveappeared during chemotherapy of tuberculous pleurisy.
Such lesions were observed in more than 10% of the cases of tuberculous pleurisy.
This type of lesion occurred more frequently in the pleurisy patients whose chest X-raydid not show any tuberculous lesion in lung field and whose sputum was negative of tuberclebacilli. Most of the patients with such lesion were young.
From these results, it was suggested that such lesion might develop during the courseof primary tuberculosis. Single nodular lesion was more common but multiple nodularlesions were not rare. They had occurred in 2-4 months after the start of anti-tuberculouschemotherapy including RFP, usually accompanied with chest pain. They had disappearedwithin 6-12 months without any additional therapy. In summary, pleural nodular lesions, which occurred during chemotherapy of tuberculous pleurisy, were not rare, but the clinicalcourse and prognosis of such lesion were favourable and improved without any additionaltherapy. The etiology of such lesion has remained to be clarified.抄録全体を表示PDF形式でダウンロード (3589K) -
河原 伸, 多田 敦彦, 竹内 誠, 神坂 謙, 岡田 千春, 三島 康男, 宗田 良, 高橋 清, 木畑 正義, 永礼 旬, 北野 裕子1994 年 69 巻 5 号 p. 351-356
発行日: 1994/05/15
公開日: 2011/05/24
ジャーナル フリーWe studied the therapeutic potential of utilizing sparfloxacin (SPFX), a newly developed quinolone, to prevent various mycobacterial infections. The in vitro activity of SPFX as a preventive agent for various mycobacteria was determined using the actual countmethod on Ogawa egg medium. The minimal inhibitory concentrations (MICs) of SPFXwere as follows: of loxacin-sensitive M. tuberculosis, 0.16-0332μEg/ml; ofloxacin- resistant M. tuberculosis, 0.63-2.5μEg/ml; M. avium; 0.63-10μEg/ml (MICs were equalor less than 1.25μEg/ml in seven out of 11 strains); M. intracellulare, 2.5-10μEg/ml (MICswere equal or more than 10μ/ml in 17 out of 23 strains); M. kansasii, ≥0.08μg/ml; M. chelonae subsp. abscessus, 1.25μg/ml; M. chelonaesubsp. chelonae, 0.63μg/ml; M. scrofulaceum, μg/ml; M. nonchromogenicum, 1.25μg/ml; M. xenopi, ≥0.08μ/ml; M. gordonae, ≥0.08μg/ml. The average serumconcentrations of SPFX during the period of multiple oral administration (200 mg once aday) were 0.35±0.16μg/ml before administration, 0.67±0.32μg/ml after one hour, 1.13±0.21μEg/ml after two hours, 1.27±0.32μg/ml after four hours and 1.31±0.34μg/ml aftersix hours. These results indicate that SPFX has a strong therapeutic potential to preventinfections due to M. tuberculosis, M. kansasii, M. fortuitum, M. chelonae subsp. chelonae, M. scrofulaceum, M.xenopi and M. gordonae. Moreover, it may be expected to be apromising agent against infections due to ofloxacin-resistant M. tuberculosis, M. aviumand M. nonchromogenicum抄録全体を表示PDF形式でダウンロード (803K) -
鈴木 公典, 山岸 文雄, 佐々木 結花, 宮澤 裕, 杉戸 一寿, 庵原 昭一1994 年 69 巻 5 号 p. 357-360
発行日: 1994/05/15
公開日: 2011/05/24
ジャーナル フリーDuring the period of eight years from 1985 to 1992 we had sixteen patients (pulmonary tuberculosis: 6, atypical mycobacteriosis: 10) who had been under the treatment for tuberculosis and on whom home oxygen therapy (HOT) was started.
Of sixteen patients twelve had history of antituberculous therapy in the past. There were nine chronic active or persistently sputum positive patients of whom three were pulmonary tuberculosis and six atypical mycobacteriosis. The duration of illness was long in these patients and it was more than ten years in tuberculosis patients.
Four cases died, two cases of pulmonary tuberculosis died from hemoptysis, and two cases of atypical mycobacteriosis died from respiratory failure.抄録全体を表示PDF形式でダウンロード (524K) -
IFN-γ 産生能を指標として友田 恒一, 米田 尚弘, 塚口 勝彦, 吉川 雅則, 徳山 猛, 夫 彰啓, 福岡 和也, 仲谷 宗裕, 成田 亘啓, 田坂 博信1994 年 69 巻 5 号 p. 361-365
発行日: 1994/05/15
公開日: 2011/05/24
ジャーナル フリーWe investigated the responsiveness of peripheral blood lymphocytes (PBLs) from patients with M. avium-intracellulare complex (MAC) infection to the stimulation with PPDs by measuring their IFN-γ producing ability. PBLs were obtained from MAC patients at active stage (culture-positive after three-month chemotherapy), those at inactive stage (culture-negative for three months after or during chemotherapy), and healthy donors. PPDs used were PPDS prepared from M. tuberculosis, PPD-B from M. intracellulare, and PPD-Y from M. kansasii.
PBLs from active MAC patients did not produce IFNγ to a significant extent b; stimulation with any of three PPDs, while PBLs from inactive MAC patients showed highe responses to each PPD compared to those from active patients. In inactive MAC patients the maximal response was observed to PPD-B among three PPDs. On the other hand, PBL from healthy controls produced different levels of IFNγ in response to three differen PPDs, and their response was most remarkable to PPD-S.
These results indicated that the responsiveness of patients' PBLs to PPDs was impaired during active stage of MAC infection and restored on recovery from the disease.抄録全体を表示PDF形式でダウンロード (620K) -
和田 雅子, 山本 節子, 尾形 英雄, 杉田 宣博, 木野 智慧光, 林 彰1994 年 69 巻 5 号 p. 367-374
発行日: 1994/05/15
公開日: 2011/05/24
ジャーナル フリーIt was reported that HIV-infected persons were at much higher risk to develop active tuberculosis than HIV-none-infected persons, about 10% of whom might develop active tuberculosis through their lives, almost identical percentage of HIV-infected persons had developed active tuberculosis annually. In Japan, 2838 HIV-infected persons including 621 AIDS-cases were reported by the end of June 1993. Oct. Ten HIV-infected cases of active mycobacteriosis have been reported in literatures or on scientific meeting. We experienced two tuberculosis cases with HIV-infection recently and will report herein.
First case: A 23 years-old male student of Japanese-language school from Myammer.He was admitted to our hospital because of high fever and cough. His chest X-ray filmtaken on admission showed left hilar and mediastinal lymph nodes swelling, calcification ofleft hylar lymph node and infiltration in middle lung field. Sputum smear for acid fastbacilli was strongly positive. The cultured isolates were identified as Mycobacteriumtuberculosis by DNA probe methods and were susceptibility tests were sensitive to allantituberculous drugs. Tuberculine skin reaction was negative. Laboratory data on admission: serum albumin level was 2.7g/dl, A/G ratio was 0.75, CRP was 26.4 dg/ml, HBeantigen and antibody were positive, HIV antibody was positive by PA method and Westernblott method, total lymphocyte count was 410/μl, total T lymphocyte count was 303/μl, total B lymphocyte count was 29/μl, CD4+ T lymphocyte count was 37/μl, CD8+ T lymphocytecount was 279/μl, CD4+/CD8+ ratio was 0.1. He was treated with streptomycin 1g per day twice a week, isoniazid 0.4g per day, rifampicin 0.45 g per day and pyrazinamide 1.2g per day. After two monthes his clinical symptoms were improved and he discharged.抄録全体を表示PDF形式でダウンロード (3736K) -
豊田 誠1994 年 69 巻 5 号 p. 375-377
発行日: 1994/05/15
公開日: 2011/05/24
ジャーナル フリーIt has been proposed that “the risk index” obtained by multiplying the score of sputum- smear examination (Gaffky number) by the duration of symptomatic period in months is useful for the prediction of the infectiousness of a tuberculosis patient. To verify this theory, contacts examination of 498 index cases, who were newly registered by the Kochi Chuo Health Center from 1986 to 1988 as pulmonary tuberculosis patients, was carried out.
Of the index cases, 58 cases (11.6%) were suspected to be responsible for significantly strong tuberculin reactions of one or more persons among their respective contacts.
The proportion of such infectious cases was higher among the smear-positive index cases as well as those with cough, in comparison with smear-negative ones and those without cough. The rate of infectious case rose significantly according to the rank of “the risk index” of the index case.
From these results, it was concluded that “the risk index” was useful to predict the infectiousness of the tuberculosis patients.抄録全体を表示PDF形式でダウンロード (430K) -
1994 年 69 巻 5 号 p. 379
発行日: 1994年
公開日: 2011/05/24
ジャーナル フリーPDF形式でダウンロード (65K) -
厚生省保健医療局エイズ結核感染症課編1994 年 69 巻 5 号 p. 383-385
発行日: 1994/05/15
公開日: 2011/05/24
ジャーナル フリーPDF形式でダウンロード (341K)
- |<
- <
- 1
- >
- >|