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Volume 71, Issue 12
Displaying 1-5 of 5 articles from this issue
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CLINICAL EVALUATION OF ANTI-TBGL ANTIBODIES ASSAY KITTakeo TOYODA, Mitsuhiko OSUMI, Teruo AOYAGI, Takeo KAWASHIRO1996 Volume 71 Issue 12 Pages 655-661
Published: December 15, 1996
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSKyowa Medex Co., Ltd. developed the kit for the sero-diagnosis of tuberculosis, which detects IgG antibodies against tuberculous glycolipids antigen containing cord factor (TBGL antigen) prepared from M. tuberculosis using the enzyme-linked immunosorbent assay technique. We evaluated the kit using clinical specimens and the results are as follows:
1) In total, 34 out of 39 cases (87.2%) with active pulmonary tuberculosis showed positive anti-TBGL antibody.
2) Patients with cavity, patients with extensive lesions and patients excreting large amount of acid fast bacilli tended to show high positivity rates.
3) The antibody titers increased in 7 out of 11 cases after starting the antituberculous chemotherapy.
4) The use of the antibody is unsuitable for the determination of the activity of tuberculosis since the antibody titers only slightly decreased even after chemotherapy for two years.
5) Two out of four nontuberculous mycobacteriosis cases showed high antibody titers.
6) All three AIDS patients with tuberculosis showed low antibody titers.
7) The antibody was negative in almost all healthy controls showing a positive PPD skin test after vaccination with BCG, and it was therefore assumed that the antibody titer is not increased by BCG vaccination.
8) The antibody titers of the staff members working in the tuberculosis wards were not high compared with those of staff members working in the other wards.View full abstractDownload PDF (747K) -
Kazuhiko OGAWA, Hironobu KOGA, Bing YANG, Miho FUKUDA, Hideaki OHNO, Y ...1996 Volume 71 Issue 12 Pages 663-669
Published: December 15, 1996
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSPleural fluids obtained from 26 patients with tuberculous pleurisy (T-group), 11 with parapneumonic pleurisy (B-group) and 21 with malignant pleurisy (M-group) were tested for their biologic parameters and cytokine concentrations.
1) The average age of T-group was over 10 years lower than that of M-group with a statistically significant difference.
2) The average CRP value of B-group and the positivity on PPD skin test of T-group were higher than those of the other groups, respectively.
3) Yellowish pleural fluids were mainly observed in T-and B-group, while bloody pleural fluids were mostly seen in M-group with a statistically significant difference. The average total protein amount and adenosine deaminase value in pleural fluid significantly increased in T-group. The percentage of polymorphonuclear leukocytes showed a significant increase in B-group, while lymphocytes significantly increased in T-group with a statistically significant difference.
4) Although no significant difference in concentrations of IL-1β, IL-2, IFN-γ and TNFa in serum was noticed among the three groups, the average concentrations of IFN-γ and TNF-α in pleural fluid in T-group were significantly higher than those in the other groups.
5) TNF-α-mRNA of mononuclear cells in pleural fluid was strongly expressed in 3 out of 11 patients of T-group, while no expression was observed in 6 patients of M-group.
In conclusion, the measurement of concentrations of two kinds of cytokines in pleural fluid, IFN-γ and TNF-α, may be clinically useful for the differential diagnosis of tuberculous pleurisy from parapneumonic pleurisy and malignant pleurisy.View full abstractDownload PDF (950K) -
Ken SATOH, Yukio MIURA, Toshihiro NUKIWA, Masakichi MOTOMIYA1996 Volume 71 Issue 12 Pages 671-675
Published: December 15, 1996
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSIndex case (S. K.) was a postgraduate in one institute of Tohoku University and was diagnosed as pulmonary tuberculosis by regular health check-up. Examinations of sputa indicated Gaffky 6 on smear and I II in culture, respectively. Five months after the diagnosis of the index case, a professor (O. K.) who was teaching S. K. in the same institute was diagnosed as tuberculosis by the chest X-ray survey. One month later, another postgraduate (M. J.) studying in other institute was found to affected with tuberculosis by regular health check-up. Since two institutes were distant from each other, it seemed that neither S. K. nor O. K. had an opportunity to contact with M. J. It was revealed, however, that two postgraduates received some lecture in the same classroom twice a week. Considering all these facts, three cases presented here are regarded as tuberculosis outbreak in the university.View full abstractDownload PDF (609K) -
Teruo AOYAGI1996 Volume 71 Issue 12 Pages 677-702
Published: December 15, 1996
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSDownload PDF (3832K) -
1996 Volume 71 Issue 12 Pages 703-705
Published: December 15, 1996
Released on J-STAGE: May 24, 2011
JOURNAL FREE ACCESSDownload PDF (342K)
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