Kekkaku(Tuberculosis)
Online ISSN : 1884-2410
Print ISSN : 0022-9776
ISSN-L : 0022-9776
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Volume 72, Issue 1
Displaying 1-5 of 5 articles from this issue
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  • THE CLINICAL STUDY OF CLARITHROMYCIN FOR PULMONARY MYCOBACTERIUM AVIUM-INTRACELLULARE COMPLEX INFECTION
    Masahiko YAMAMOTO, Fumiyuki KUZE, Mitsunori SAKATANI, Hajime SAITO, Hi ...
    1997 Volume 72 Issue 1 Pages 1-7
    Published: January 15, 1997
    Released on J-STAGE: May 24, 2011
    DOIhttps://doi.org/10.11400/kekkaku1923.72.1
    JOURNAL FREE ACCESS
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    A nationwide study was conducted to investigate the efficacy of Clarithromycin (CAM) on pulmonary atypical mycobacteriosis caused by the Mycobacterium avium-Mycobacterium intracellulare complex, including intractable cases. Out of total 97 patients examined, the analysis for bacteriological efficacy was possible in 69 cases. The negative conversion of bacilli was observed in 18 cases (26.1%), and 5 out of 12 cases in which the follow-up was conducted turned out continued negative status. The efficacy of CAM was relatively high in the following cases: the duration of the disease was less than 6 months; the extent of pulmonary lesions on chest roentogenograms was limited or moderate; and antituberculous agents which were previously unused were applied in combination with CAM. Also, the efficacy was high in cases where the dose of CAM was 600 mg/day or higher. Major side effect was mild to moderate digestive symptoms. In conclusion, at daily dose of 600 mg or higher, CAM was effective in the elimination or reduction of M. avium-M. intracellulare complex that caused atypical mycobacteriosis, without developing serious side effect. Treatment with this drug should be attempted in intractable cases.
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  • THE COMBINATION OF AMOXICILLIN-CLAVULANIC ACID AND OFLOXACIN IN THE TREATMENT OF MULTIDRUG-RESISTANT MYCOBACTERIUM TUBERCULOSIS
    Tomoaki IWANAGA, Kinji YOKOTA, Reiko KISHIKAWA, Togo IKEDA, Hideto TSU ...
    1997 Volume 72 Issue 1 Pages 9-13
    Published: January 15, 1997
    Released on J-STAGE: May 24, 2011
    DOIhttps://doi.org/10.11400/kekkaku1923.72.9
    JOURNAL FREE ACCESS
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    A 53-year-old man with multidrug resistant tuberculosis (MDR-TB) had been persistently positive for acid-fast bacilli (AFB) both on sputum smear and also on culture with the Ogawa egg medium for 30 years since 1951. The case had been treated previously with isoniazid, rifampin, streptomycin, ethambutol, kanamycin, ethionamide, paraaminosalicylate and cycloserine; however, M. tuberculosis strains isolated from this patient acquired a high resistance to all of these agents. Then, a new regimen of chemotherapy, INH combined with ofloxacin (OFLX) and amoxicillin-clavulanic acid (AMPC/CVA), was applied to the case. He was successfully treated with this regimen, and a marked decrease in the amount of AFB on smear as well as on culture was observed during the course of chemotherapy. No adverse effects were seen meanwhile. These data suggest that it is worth while to try a regimen containing AMPC/CVA and OFLX in the treatment of MDR-TB.
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  • 2 CASES OF LUNG DISEASE CAUSED BY MYCOBACTERIUM AVIUM COMPLEX OCCURRED IN MIDDLE-AGED WOMEN WITHOUT UNDERLYING DISORDERS, WHICH WE OBSERVED FOR MORE THAN 30 YEARS
    Shunji TAKAKURA, Eisaku TANAKA, Woon J. LEE, Hisako MATSUMOTO, Kazunar ...
    1997 Volume 72 Issue 1 Pages 15-20
    Published: January 15, 1997
    Released on J-STAGE: May 24, 2011
    DOIhttps://doi.org/10.11400/kekkaku1923.72.15
    JOURNAL FREE ACCESS
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    We reported 2 cases of Mycobacterium avium complex lung disease occurred in middleaged women without underlying disorders, which we could observe for more than 30 years. One case was a 42-year-old woman started with bloody sputum, and the other was a 43-year-old woman with cough and sputum. In both cases, chest X ray films were normal on their first visit. More than 15 years after their first visit, Mycobacterium avium complex was isolated from their sputum or bronchial washing. During the observation, a cluster of small nodules in the periphery of the lung and bronchiectasis appeared and deteriolated, and excretion of the bacilli increased gradually. Their past history and family history were normal. Since lung disease caused by Mycobacterium avium complex progresses very slowly, long-time observation would be necessary to consider its pathogenesis.
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  • The 71st Annual Meeting Symposium
    Takashi ARAI
    1997 Volume 72 Issue 1 Pages 21-56
    Published: January 15, 1997
    Released on J-STAGE: May 24, 2011
    DOIhttps://doi.org/10.11400/kekkaku1923.72.21
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  • [title in Japanese]
    1997 Volume 72 Issue 1 Pages 57-59
    Published: January 15, 1997
    Released on J-STAGE: May 24, 2011
    DOIhttps://doi.org/10.11400/kekkaku1923.72.57
    JOURNAL FREE ACCESS
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