The Keio Journal of Medicine
Online ISSN : 1880-1293
Print ISSN : 0022-9717
ISSN-L : 0022-9717
Volume 1, Issue 2
Displaying 1-9 of 9 articles from this issue
  • DAIZO USHIBA, CHOSHI TAKAMURA, SOROKU YAMAGATA, IKUSHI JO, TOSHIHIKO O ...
    1952 Volume 1 Issue 2 Pages 81-94
    Published: 1952
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
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  • HISAKICHI MATSUBAYASHI
    1952 Volume 1 Issue 2 Pages 95-105
    Published: 1952
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
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  • MASAHIRO KOJIMA
    1952 Volume 1 Issue 2 Pages 107-121
    Published: 1952
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
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  • SHIGESHI TOYOSHIMA
    1952 Volume 1 Issue 2 Pages 123-129
    Published: 1952
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    (1) By studying the action of plasma against Oxo-HCl, it has been discovered that plasma increases or decreases its efficiency according to the quantity used.
    (2) This fact allows the presumption that there exists, in plasma protein fraction, a part which increases its efficiency and parts which decrease its efficiency. This efficiency increasing part is eu-Globulin; the efficiency decreasing parts are albumin and pseudoglobulin.
    (3) With the addition of eu-globulin the efficiency of Oxo-HCl is increased, the toxicity is decreased slightly, and the chemotherapeutic index grows 3 times as that of Oxo-HCl alone.
    (4) This action of eu-globulin requires some time for reaction after mixing. From this fact it is inferable that a compound is found by a loose combination between Oxo-HCl and the separate acid group of the amino acid constructing eu-globuline.
    (5) Oxo-HCl obstructs red blood cell cholinesterase, and also inhibits plasma cholinesterase. From this fact, it is deduced that one cause for side reaction of Oxo-HCl might lie in the inhibitory action against cholinesterase.
    (6) When cysteine or Benadryl is mixed with Oxo-HCl, the inhibitory action against cholinesterase is decreased. From this, it is thought that anti-histamine drug passosses an action which markedly lowers the toxicity of Oxo-HCl.
    (7) The action of anti-histamine drug (Benadryl and pyribenzamine) which lowers the toxicity of Oxo-HCl is superior to that of cysteine and glutathione, and is equal to that of BAL. And, as the action which lowers its efficiency is less than that of SH compounds, the author thinks, the anti-histamine drug are to be given proper attention as the toxicity reducing drug against Oxo-HCl.
    Acknowledgement. The author is indebted to T. Mizuma and K. Takahashi for chemical experiments.
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  • REPORT OF TWO CASES OF EOSINOPHILIA ASSOSIATED WITH EITHER ERYTHROBLASTOSIS FETALIS OR INFANTILE HYPOPLASTIC ANEMIA
    GENJU OONEDA
    1952 Volume 1 Issue 2 Pages 131-138
    Published: 1952
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Two cases of marked eosinophilia accompanied by either erythro- (leuko) -blastosis fetalis or infantile hypoplastic anemia have been reported with hematologic and pathologic descriptions.
    The former case was characterized by the, marked erythroblastosis in various viscera, and the latter case by the marked suppression of erythropoiesis, both cases presenting alike marked eosinophilia in the bone marrow, spleen, liver and blood.
    The intimate relationships between the abnormal erythropoiesis and eosinophilia in these cases are considered as the results of the disturbed metabolism of porphyrin, which is the common component of the cytochrome in the eosinophile granules and the hemoglobin in erythrocytes.
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  • YOSHIMITSU TSUJIYAMA
    1952 Volume 1 Issue 2 Pages 139-141
    Published: 1952
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    The writer has described a new oligodendrogia impregnation method using cyanide. The oligodendroglia of normal or schizophrenia brain could be stained selectively, but if the section is soaked in ammoniacal silver solution a little longer, microglia will come to view. This shows that each of oligodendroglia and microglia has its own chronologic phase. The chronologic phase of glia shows remarkable differences under pathologic conditions.
    For instance, the chronologic phase of microglia of general paresis, or that of macroglia of tuberous sclerosis and glioblastoma multiforme is dislocated to the site of oligodendroglia.
    The writer has encountered a huge, weed-like cell in the molecular layer of cerebellum of schizophrenia, which is interpreted as a transformation of Bergmann's cell stained by his new method probably because of the dislocated chronologic phase.
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  • YUKIO NAGAKI
    1952 Volume 1 Issue 2 Pages 143-160
    Published: 1952
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    1. By peroral and parenteral giving of anti-erythrocyte serum and anti-serum serum and parenteral giving of anti-bone marrow serum, pathologic changes very similar to the human hemolytic disease were produced in newborn rats, but failed to do so in the peroral and parenteral giving of anti-liver serum.
    2. Pathologic changes very similar to the so-called hemolytic jaundice were demonstrated in adult rats by subcutaneous injection of anti-erythrocyte serum, but not by its peroral giving except for a slight increase of erythroblasts in the bone marrows of all cases and increase of erythroblasts in the bone marrows of all cases and slight anemia in one case.
    3. When anti-erythrocyte serum was given to newborn rats perorally, refined vaccine virus and refined vaccine virus plus vitamine C could inhibit the appearance of jaundice completely, but not when that anti-serum was given subcutaneously.
    4. When anti-erythrocyte serum was given to adult rats, the appearance of jaundice could not be completely inhibited, while refined vaccine virus and cystine inhibited it to a certain degree.
    5. The erythroblasts in circulating blood consisted of normoblasts of almost the same stage of development and their protolasma were orthochromatic or polychromatic except for some which were basophylic The anisocytosis of the red cells was conspicuous and especially a remarkable increase in the number of microcytes was noticed.
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  • HISAO KABAYAMA
    1952 Volume 1 Issue 2 Pages 161-167
    Published: 1952
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    I have studied the eye-sight through fog with the artificial fog. Results of my experiments are as follows;-
    Fig. 5
    (1) The logarithm of visual acuities make a linear function to the density of a fog, and a following empirical formula is derived.
    log V=-f 1(Et, Ef )de+f 2(Et, Ef ) log V=visus logarithmicus f 1(Et, Ef ), f 2(Et, Ef )=functions of brightness on test types and on a fog>0 de=density of a fog.
    (2) Curves, which indicate the relation between 'illuminations on test types and visual acuities through fog, are derived.
    By these curves I can say that the visual acuity becomes better by increase of brightness when the fog is rather faint, but the visual acuity through dense fog does not become better by increase of brightness.
    (3) The visual acuity through fog is weakened by the increas of the white area which encloses Landolt's rings.
    (4) As the illuminating-angle upon the fog becomes larger the visual acuity through fog becomes lower.
    (5) When the fog is relatively faint and the useless light is covered completely, the visual acuity becomes better by the increase of the illumination. Otherwise when the useless light is covered incompletely, the visual acuity does not become better by the increase of the illumination on the test type.
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  • NOBUKATSU SHIMADA, HISAO YAMASHITA, SADANORI IGARI
    1952 Volume 1 Issue 2 Pages 169-174
    Published: 1952
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
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