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Volume 10, Issue 4
Displaying 1-6 of 6 articles from this issue
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HISAO YAMASHITA, SADANORI IGARI, TOMIKO TANAKA1961 Volume 10 Issue 4 Pages 195-207
Published: 1961
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESSOn seventy cancer patients, all of whom were to receive radiation therapy for the first time, the blood and the urine were taken once a week, before and during radiation treatment, and the changes in the value of fibrinogen, in the plasmin value of the plasma, and the urine were carefully examined with the following results:
1) With a large number of cancer patients plasmin activity was found already elevated before irradiation, but in two-thirds of the cases further activation became evident after irradiation.
2) When observed according to the irradiated location, the degree of activation of plasmin was roughly in the order of upper abdomen, chest, head and neck and lower abdomen. The frequency and the time of appearance of plasmin activation almost agreed, in most cases, with the appearance of radiation sickness. The fact very well suggests that close relationship exists between plasmin activation and radiation sickness.
Thirtythree similar cancer patients were treated daily with large amounts of Ipsilon throughout the duration of the irradiation with the following result:
1) It proved effective in stopping the plasmin activation, especially in arresting the activation of plasmin in the plasma and in the urine.
2) It was also found effective in arresting radiation sickness., In only 3 cases (9.1%) out of the 33 were radiation symptoms noted.
3) Decrease of the leucocyte count was also prevented to a certain degree by the treatment.
4) No side effects were perceived from daily 3 g administration of Ipsilon in divided doses.View full abstractDownload PDF (722K) -
HISAKICHI MATSUBAYASHI, TAMOTSU KOIKE, MISAO UYEMURA, YASUTO SOH, KENJ ...1961 Volume 10 Issue 4 Pages 209-224
Published: 1961
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESSA research assistant in the Department of Pathology, School of Medicine, Keio University, Tokyo, made a necropsy of a toxoplasmosis child and had accidentally a splash of the cerebrospinal fluid on his face. Six months later he had disseminated lung infiltrations and two and half years later he suddenly lost the normal sight of his left eye due to chorioretinitis which was considered to be due to tuberculosis at that time. One year after the onset of the chorioretinitis the patient had for the first time Sabin-Feldman dye test which was positive with a titer of 1:256. Cerebrospinal fluid was examined by direct smear and mouse passages, but no Toxoplasmas were found.
Chorioretinits persisted changing continuously its localization and intensity. About four months after the first dye test, the second test was made which gave a titer of 1:1024 and on the next day subretinal fluid was withdrawn and inoculated into mice. By the serial passages, typical Toxoplasmas were demonstrated. The dye test titer became 1:4096 ten days after the drainage.
Although daraprim and sulfadiazine were used for treatment, they have had no effect and the chorioretinitis still persist at present or 20 months after the oneset. In all probability, the infection occurred at the necropsy, provoked the disseminated lung infiltrations and became chronic thereafter producing cysts in brain and retina. Cysts in retina might have undergo rupture and the chorioretinitis ensued first by the allergic response and later by the prolife-ration of the parasites.
Daraprim and sulfadiazine treatment had no recognizable effects.View full abstractDownload PDF (2050K) -
HIDEO WAKAMATSU1961 Volume 10 Issue 4 Pages 225-238
Published: 1961
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESS1) The concentrations and the fractions of serum glycoproteins were meas-ured in normal, obese, and arteriosclerotic subjects.
2) The levels of serum P.B.H. and seromucoid showed a tendency of in-creasing with aging. The concentrations of both serum P.B.H. and seromucoid in the middle aged normal subjects were significantly higher than those in the normal young, but were not significantly lower than those in the aged group.
3) In the middle aged obese group, the serum P.B.H. and the seromucoid levels were significantly elevated than control values. Significant possitive correlations between serum glycoprotein (both serum P.B.H. and seromucoid) levels and the obesity indexes were observed.
4) In the arteriosclerotic subjects, as a whole, only the mean value of seromucoid was significantly elevated than the control value. The arterios-clerotic patients were divided into two groups, the middle aged and the aged. In the middle aged arteriosclerotic group, the serum P.B.H. level was significantly increased. The slight elevation of the seromucoid level in this group was not statistically significant. On the contrary, in the aged arteriosclerotic group with or without cerebrovascular accident, the seromucoid level was markedly increased. The serum P.B.H. level of patients with history of cerebrovascular accident was significantly elevated in those who were fed well, and was reduced in those who could not take sufficient diet due to serious motor disturbances.
5) The electrophoretical migration of serum glycoproteins was changed with aging. The albumin fraction was significantly decreased and the a-1 globulin fraction was significantly increased in the aged group compared with those values in the young group. The values of those fractions in the middle aged group were intermediate.
6) The electrophoretical migration of serum glycoproteins showed no change in the middle aged obese subjects.
7) The a-1 globulin fraction of serum glycoproteins was significantly increased in the arteriosclerotic subjects. In the middle aged arteriosclerotic group, the albumin fraction was significantly decreased, and the a-1 globulin fraction was significantly increased compared with the control value. In the aged arteriosclerotic group, a significantly increased a-1 globulin fraction was observed.
8) The concentrations of serum P.B.H. and seromucoid of the same indivi-dual were not different in the morning or in the afternoon.View full abstractDownload PDF (1451K) -
MITSUO HOMMA, KINSUKE IMURA, HIROSHI AIZAWA1961 Volume 10 Issue 4 Pages 239-250
Published: 1961
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESSThirteen patients with acute rheumatic fever in young adults and adults were treated with 3 g or 6 g of aspirin. Three grams of aspirin had a similar dramatic effect to the toxic symptoms of fever and arthralgia etc. as 6g of aspirin. However, for the improvement of acute phase reactants, 6 g was definitely superior to 3g.
Based on the study of the change of Urinary 17-KS and circulating eosino-phils counts, such differences were assumed that 6 g of aspirin seemed to have non-specific ACTH-like effects other than the specific pharmacological effects of aspirin. These ACTH-like effects were not proved from the point of carbohydrate metabolism. The disturbances of atrio-ventricular conduction were improved by aspirin. Side effects of aspirin were found in two-thirds of the cases. Chondroitin sulfate tolerance test was reported as an index of cessation for anti inflammatory drugs.View full abstractDownload PDF (605K) -
TADATAKA FUNAO1961 Volume 10 Issue 4 Pages 251-255
Published: 1961
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESS(1) Cerebral pH coeficient does not show significant changes between brain functional disorders and others.
(2) GOT of brain decrease, and of cerebrospinal fluid increase in brain functional disorders, especially in contusion.
(3) These enzymological changes were seen at experimental studies in animals.View full abstractDownload PDF (182K) -
PART 1. THE INHIBITORY EFFECT OF GUANIDINE ON THE MULTIPLICATION OF POLIOMYELITIS VIRUS IN TISSUE CULTURETAKEO UEDA, SHIGESHI TOYOSHIMA, TADAKAZU TSUJI, YOSHIKO SETO, JUNKO NO ...1961 Volume 10 Issue 4 Pages 257-265
Published: 1961
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESSThe antiviral effect of Guanidine on poliomyelitis virus in HeLa cells was investigated. 10-3M of Guanidine exerted the remarkable inhibitory effect on the multiplication of all of type-1, type-2 and type-3 of poliomyelitis virus. The inhibitory effect of Guanidine should neither be due to the virus inactivating action nor be caused by the influence on the viral adsorption onto host cells. From the results presented in this paper, it should be emphasized that the action site of this compound should be in the intracellular viral multiplication, particularly in the reproduction stage of the multiple cycle of viral growth.View full abstractDownload PDF (505K)
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