The Keio Journal of Medicine
Online ISSN : 1880-1293
Print ISSN : 0022-9717
ISSN-L : 0022-9717
Volume 11, Issue 1
Displaying 1-6 of 6 articles from this issue
  • MASATAKA KATSU, TAKAO SAEKI, TOHRU ABE
    1962 Volume 11 Issue 1 Pages 1-10
    Published: 1962
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
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  • II. EFFECT OF THE PREDNISOLONE TREATMENT ON RHEUMATIC FEVER
    MITSUO HOMMA
    1962 Volume 11 Issue 1 Pages 11-23
    Published: 1962
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    The value of large doses of steroidhormone for rheumatic fever was studied and compared with that of moderate doses of hormone and aspirin. The effects on toxic symptoms, acute phase reactants, cardiac symptoms, side effects, and the inflammatory process calculated by the chondroitin sulfate tolerance test were observed.
    1) The effect of large doses of hormone on the acute phase reactants was markedly superior.
    2) The effect of large doses of hormone on the heart size was not found to have a marked difference from the other groups. However, from the view-point of the complete disappearance of heart murmur, two cases were found in the large dose hormone group.
    3) The inflammatory process seemed to be shortened when large doses of steroidhormone were used in the early stage.
    4) The rebound phenomena found in this report seemed to be different from relapse.
    5) Side effects which necessitated the withdrawal of hormone were not found.
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  • YUJI SUEYOSHI, YOSHIKAGE NAGAO
    1962 Volume 11 Issue 1 Pages 25-32
    Published: 1962
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    In order to find the reason why there is only a small amount of linoleic acid in the unsaturated fatty acids fraction of phospholipids in the tumor tissue, the authors have made studies about this point on the transplanted sarcoma and neighboring normal muscle tissues of the rats.
    1) The amounts of total unsaturated fatty acid in the phospholipids of the tumor and that of the normal muscles are almost equal.
    2) The amounts of linoleic acid and linolenic acid of phospholipids of the tumor are of very small quantity compared with the amounts of that of the phospholipids of the normal muscles. Especially, the amount of linoleic acid is of remarkably small quantity.
    3) The mechanism under which the above phenomena appear can be thought of as follows:
    (a) The linoleic acid in the diet might be very difficult to be incorporated into the phospholipids of the tumor, or
    (b) The linoleic acid of phospholipids of the tumor might disappear at a more rapid rate than that of normal muscles.
    Investigating on these two factors, the authors obtained the following results:
    (A) When linseed oil is added to the diet and fed to the rats for 7 days, in- crease of the linoleic acid portion of unsaturated fatty acid of phospholipids of normal muscle is 5.44%, whereas that of tumor tissue is 13.83%.
    According to this result, the rate of incorporation of linoleic acid from the diet into the phospholipids is more rapid in the tumor tissue than in the normal muscles. The same result is obtained when the linseed oil diet is given for 4 days.
    (B) After the linseed oil diet is given for 7 days, then the fat-free diet is given from 1-7 days, and the tissues of these animals are analyzed. Results show that the linoleic acid of phospholipids of the normal muscles is not decreased even after 3 days and only a slight amount of decrease is noted after 7 days. However, on the fat-free diet, even after 1 day, the linoleic acid of phospholipids of the tumor shows some decrease, and on the 2nd and 3rd days the decrease is remarkable. According to this result, the disappearance of linoleic acid in the phospholipids is more rapid in the tumor than in the normal muscles.
    4) According to the above results, the amount of the linoleic acid in the phospholipids of the tumor is less than that in phospholipids of the normal muscles, not because of difficulty of incorporation of linoleic acid from the diet into the phospholipids of the tumor, but due to its rapid disappearance from the tumor tissue.
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  • SHIGESHI TOYOSHIMA, YOSHIKO SETO, TAKEO UEDA
    1962 Volume 11 Issue 1 Pages 33-41
    Published: 1962
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
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  • I. PLASMA ANTIDIURETIC ACTIVITY AND URINARY SODIUM-RETAINING ACTIVITY IN PATIENTS WITH EDEMATOUS DISEASES
    KIYOFUMI HIRATA, TAKASHI HAGIWARA, EIICHI KATO, SEIICHI ASANO, TOYOZO ...
    1962 Volume 11 Issue 1 Pages 43-50
    Published: 1962
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Both antidiuretic activity of the plasma and sodium-retaining activity of the urine from patients with edmatous diseases were assayed. The results obtained are as follows;
    Both plsma antidiuretic activity and urinary sodium-retaining activity were increased in patients with so-called secondary hyperaldosteronism.
    Some correlation between urinary sodium-retaining activity and sodium output was found in the limited groups of patients assayed, but no correlation was observed in patients with cirrhosis of the liver.
    In bioassay of crude extracts of urine from some cases of non-edematous patients, the negative value, i.e. sodium-excreting activities were obtained.
    On the basis of our findings, the roles of ADH and aldosterone in the pathogenesis of edema formation and the possibility of the presence of sodium-excreting hormones in human body were discussed.
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  • II. CLINICAL OBSERVATIONS ON THE DIURETIC EFFECTS OF ACTH, GLUCOCORTICOIDS, ADRENAL CORTICAL INHIBITOR, AMPHENONE OR ALDOSTERONE ANTAGONIST, SC-9420
    KIYOFUMI HIRATA, TAKASHI HAGIWARA, HIROSHI KURODA, EIICHI KATO, SEIICH ...
    1962 Volume 11 Issue 1 Pages 51-63
    Published: 1962
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Clinical observations were made on the diuretic effects of ACTH, gluco-corticoids, adrenal cortical inhibitor, amphenone or aldosterone antagonist, SC-9420. The following results were obtained.
    1. In patients with nephrotic syndrome treated with ACTH or some kind of glucocorticoids, three patterns of diuresis were noted, namely one preceding, others in parallel with and still others following the improvement of proteinuria.
    2. In patients with cirrhosis of the liver treated with amphenone or SC-9420, diureses of water, sodium and chloride were noted without the significant increase of potassium excretion. Sometimes a delayed onset of diuresis was noted.
    3. In nephrotic patients treated with glucocorticoids in combination with either amphenone or SC-9420, a rather prompt and marked diuresis was noted without any improvement of proteinuria.
    4. Balance studies for internal fluid shift during diureses induced by ACTH, some kind of glucocorticoids, SC-9420 or SC-9420 plus prednisolone demonstrated an increased excretion of water and sodium derived from both extra-and intracellular compartment, and also a transportation of potassium into intracellular compartment. Similar results were obtained during diureses induced by rest alone or rest with salt-free diet in normal subjects.
    5. Decreased urinary 17-ketosteroids and chemocorticoids in edematous patients were observed.
    On the basis of our observations, a working-hypothesis concerning the mecha-nisms of action of these agents was presented.
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