The Keio Journal of Medicine
Online ISSN : 1880-1293
Print ISSN : 0022-9717
ISSN-L : 0022-9717
Volume 12, Issue 1
Displaying 1-6 of 6 articles from this issue
  • PRELIMINARY REPORT
    TATSUYUKI KUDO
    1963 Volume 12 Issue 1 Pages 1-8
    Published: 1963
    Released on J-STAGE: May 26, 2009
    JOURNAL FREE ACCESS
    This new method of prolonged total body circulatory interruption is devised under extremely profound hypothermia by means of the exchange perfusion of a blood substitute using extracorporeal circulatory machine.
    There are several significances of this method:
    1) Prolonged total body circulatory interruption is obtained.
    2) Temperature near 0°C is obtained very rapidly.
    3) An absolutely bloodless surgical field is secured under this condition.
    4) No sequelae are noticed after recovery.
    5) No blood is perfused during the cooling period. This procedure facilitates high flow and rapid cooling.
    6) A great future is expected to perform a riskful operation radically and safely under this new method.
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  • TOYOAKI SAITO
    1963 Volume 12 Issue 1 Pages 9-16
    Published: 1963
    Released on J-STAGE: May 26, 2009
    JOURNAL FREE ACCESS
    The present studies described the microcirculatory disturbances during immediate type of allergic reaction on the guinea pig mesentery under the microscopic observation. The changes were obsrved for about 2 hours after topical application of the antigen. The results of these experiments were as follows.
    1. The process of microcirculatory changes could be classified into two stages, the earlier and the later. In the earlier stage, stasis in capillaries and venules, erythrocytic aggregation in venules, and arteriolar contraction occurred, and recovered after several minutes duration. In the later stage, changes were mainly observed in venules; lukocytic sticking to the endothelium, leukocytic emigration, white thrombosis, and hemorrhage. Hemorrhage was observed at the points of capillary-venular or venulo-venular junctions.
    2. The mechanisms of each phenomenon were discussed, and the significant role of the venule in local allergic reaction was emphasized.
    The author's grateful acknowledgement is made to Prof. Dr. Kageyama for his kind guidance. Thanks are also due to Drs. Yamaguchi and Tozawa, without whose assistance and advice this project would have been impossible.
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  • YUJI SUEYOSHI, HANAKO ODA
    1963 Volume 12 Issue 1 Pages 21-25
    Published: 1963
    Released on J-STAGE: May 26, 2009
    JOURNAL FREE ACCESS
    1) When groups of rats of various body weights were fed on a diet deficient in the polyunsaturated fatty acid, all the animals in Group I (average body weight of 52g), Group II (average body weight of 60g), Group III (average body weight of 65g), and Group IV (average body weight of 73g) died during 56, 72, 79, and 85 days, respectively. Whereas in Group V, the control (average body weight of 53g), all the animals were still alive after 86 days of feeding, this being ascribed to the supplementation to the diet with linseed oil containing the polyunsaturated fatty acid. The data also indicate that the younger the animals the less resistant they are to the polyunsaturated fatty acid deficiency.
    2) There was a marked difference in the linoleic acid content of the unsaturated fatty acid in the fat of the lipid constituents of muscles between the mature (5.5%) and the immature rats (29.2%). The linoleic acid contents in the phosphatide was 33.1% in the mature and 42.3% in the immature rats. The amounts of linolenic and arachidonic acids were slightly more in the immature than in the mature rats.
    3) The above results indicate that the younger animals die in the earlier period of feeding the polyunsaturated fatty acid deficient diet, because they require more of the polyunsaturated fatty acid to construct their cells.
    4) According to Ara's data on the lipid constituents of animal cells(3), the iodine number of the fatty acid of fat is 100 and that of phosphatide is 115. When the iodine number of fatty acid is more than 100, it cannot be attained by oleic acid alone but the polyunsaturated fatty acid must be participated. The present study revealed that the younger the animals the more of the poly-unsaturated fatty acid they require.
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  • YUJI SUEYOSHI, HANAKO ODA
    1963 Volume 12 Issue 1 Pages 27-29
    Published: 1963
    Released on J-STAGE: May 26, 2009
    JOURNAL FREE ACCESS
    1) The amounts of polyunsaturated fatty acids in the total unsaturated fatty acid were as follows: linoleic acid, 7.96% in human milk and 0.96% in cow's milk; linolenic acid, 1.41% in human milk and 0.19% in cow's milk; and arachidonic acid, 1.74% in human milk and 0.1% in cow's milk. The total polyunsaturated fatty acid was 11.11% in human milk and only 1.25% in cow's milk, that is, the amount in cow's milk was only about one-tenth of that in human milk.
    2) It is generally recognized that human milk has the composition which is the most adequate for nutrition of human nurslings. Therefore, when cow's milk is used for the nourishment of human nurslings, its composition should be similar to that of human milk. This should be accomplished by supplementing cow's milk with an oil rich in the polyunsaturated fatty acid (e.g. linseed oil or cod liver oil), bringing the level of polyunsaturated fatty acid in cow's milk up to that in human milk.
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  • OSAMU TAKAHASHI, KAZUYO SHIMAI
    1963 Volume 12 Issue 1 Pages 31-34
    Published: 1963
    Released on J-STAGE: May 26, 2009
    JOURNAL FREE ACCESS
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  • YUKIO OZAWA, MAKOTO YAMAUCHI
    1963 Volume 12 Issue 1 Pages 37-52
    Published: 1963
    Released on J-STAGE: May 26, 2009
    JOURNAL FREE ACCESS
    For the purpose to study the passway of high molecular substances through glomerular capillary membrane and the permeability of that membrane in renal diseases, we used the isolated rabbit's kidney perfusion technique at 4°C (=cooled kidney) and Dextran preparation in the clearance method in order to inhibit the tubular reabsorption.
    (1) The incorporation of Imferon (Iron Dextran complex) into glomerular capillary cells in the rabbit, conditioned by normal, Masugi's nephritis, and mercurials damaged, was identical between the cooled kidney case and the control by electronmicrosocpy. Transport of high molecular substance, protein or Dextran, passed through cells in glomerular capillary membrane, is considered to be made not only actively but passively.
    (2) Urinary protein contents derived from isolated rabbit's kidney perfused with ice cold serum was supposed to resemble to that of glomerular filtrate. The protein concentration of glomerular filtrate was increased with the elevation of pressure and protein concentration on perfusion. The glomerular filtrate protein concentration was 25.9mg/dl in normal cases' average. After this procedure, kidney without injuring of glomerular capillary membrane was assured electronmicroscopically. Their fraction had much albumin, less globulin than that of serum. In pathologic states conditioned by mercurial injury and Masugi's nephritis, the glomerular filtrate contained increased protein concentration with increased globulin, and these results suggested increased permeability.
    (3) The type of distribution curve which represented glomerular permeability in various renal diseases was devided to three main type. This curve indicated permeability more appropriately than mean effective radius. In addition to this results, there should be injury of glomerular capillary membrane, Dextran fraction, over 100, 000 molecular weight, was excreted in urine.
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