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Volume 12, Issue 3
Displaying 1-6 of 6 articles from this issue
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HITOSHI HATANO, KAZUYA YAMAMOTO1963 Volume 12 Issue 3 Pages 113-116
Published: 1963
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESSDownload PDF (163K) -
ICHIRO NAKAYAMA, HISAKICHI MATSUBAYASHI1963 Volume 12 Issue 3 Pages 117-125
Published: 1963
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESSEffects of spiramycine and pyridazine were evaluated on experimental toxoplasmosis in mice infected with Beverley or RH strains, comparing with those of pyrimethamine which is known to have potent action to toxoplasma. Spiramycine and pyridazine, when used alone, showed slight killing effects on toxoplasma, although the survival period of mice was prolonged considerably.
Combined use of these two drugs proved effective in oral administration of 13 mg each per mouse, if given immediately after infection for 21 days, demonstrating no viable toxoplasma in almost all mice, experimentally infected.
Therapeutic effects of combinations of these two drugs was almost equivalent to these of pyrimethamine. The two strains of toxoplasma used, Beverley and RH, did not show any differences in susceptibility to these drugs, but this might be due to the fact that relatively enormous dosages of the drugs were administered.View full abstractDownload PDF (499K) -
EIKICHI HOSOYA, HARUO AKITA1963 Volume 12 Issue 3 Pages 127-130
Published: 1963
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESSModifying the levels of C. A. and 5HT in brain by the administration of some drugs, changes of the spontaneous activity of morphinized rats in case of morphine repetition or nalorphine administration, were carefully observed and the followings were concluded;
1. Levels of C.A. in brain have close relationship to the changes of the spontaneous activity of the animals while those of 5HT have not.
However, it is not the levels of C. A. in brain which causatively determine the increase or decrease of activity. C.A. in brain may act just as collaborators in this respect.
Authors express their hearty thanks to Dr. B. B. Brodie for the generous supply of α-M M T before it was brought on the market.View full abstractDownload PDF (182K) -
TAKEO UEDA, SHIGESHI TOYOSHIMA, ATSUSHI TAKADA, YOSHIKO SETO1963 Volume 12 Issue 3 Pages 131-137
Published: 1963
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESS(1) In order to find more effective agents than guanidine, potentiating agents were searched by means of the salt formation.
(2) The potentiating effect of some amino aicd antagonists was examined, and ethionine was found as the most marked potentiation agent among the antagonists.
(3) The potentiating effect of some of methionine homologs was examined, and any of the homologs was found not to have an effect more significant than ethionine.
(4) The potentiating effect of some of commoner organic acids was examined, but any of these acids was found not to show any potentiating effect.
(5) The mechanismus of the potentiation of guanidine with ethionine was speculated, from the hypotheses presented so far.View full abstractDownload PDF (323K) -
TAKEO UEDA, SHIGESHI TOYOSHIMA, YOSHIKO SETO1963 Volume 12 Issue 3 Pages 139-147
Published: 1963
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESSIn both of Hep. No. 2 and KB cells, arginine remarkably accelerated the development of the cytophatic effect of the type 2 strain of adeno virus. This effect, “Arginine Effect, ” was observed in not only type 2 virus but other strains such as type 1, type 5 and type 6 strains of adeno virus. The acceleration of the lowering of pH of culture fluid of the cells infected with adeno virus in the arginine rich group was not found. The stimulation of arginine on the degree and the rate of the viral release from host cells also was not found. In the group riched with arginine, the clear increase of the intracellular multiplication of adeno virus was observed. Thus, it may be considered that the main mechanism of “Arginine Effect” should be in the multiplication-mechanism of adeno virus in intracellular site. This mechanism is not of the stimulation of the activity of Ornithine-cycle, but of some specific effect of arginine on the replication-mechanism of adeno virus particles.View full abstractDownload PDF (495K) -
SHIGESHI TOYOSHIMA, SEIZABURO KANO, TAKEO UEDA1963 Volume 12 Issue 3 Pages 149-159
Published: 1963
Released on J-STAGE: March 27, 2009
JOURNAL FREE ACCESSDownload PDF (532K)
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