The Keio Journal of Medicine
Online ISSN : 1880-1293
Print ISSN : 0022-9717
ISSN-L : 0022-9717
Volume 14, Issue 4
Displaying 1-7 of 7 articles from this issue
  • ICHIRO AKAKURA, YOSHIZO NAKAMURA, TERUO KAKEGAWA, YOSHIHISA HOSHINO, T ...
    1965 Volume 14 Issue 4 Pages 145-160
    Published: 1965
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
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  • YUMIKO TAKADA, AKIKAZU TAKADA, UTAKO OKAMOTO, KANEO YAMADA
    1965 Volume 14 Issue 4 Pages 161-165
    Published: 1965
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    1) Two cases with large cephalohematomas and with high proactivator activities were reported.
    2) The total proactivator level of the infant was very high soon after birth, later decreasing and once more higher to the normal level.
    3) Proactivator A level of this infant soon after birth was very low (not detected by the clot lysis test) in spite of high proactivator B level.
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  • TOMOMI SAKURADA, HIROKO MATSUMURA
    1965 Volume 14 Issue 4 Pages 167-178
    Published: 1965
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    1. In the growth medium containing ethanol as a sole carbon source, a strain of S. cerevisiae did not multiply but its respiratory activity was fully developed. Oxidoreductases and sugar metabolism of yeast cells grown on glucose and on ethanol were investigated.
    2. Cytochrome oxidase activity and the amount of ubiquinone were much higher in the ethanol-grown cells than in the glucose-grown cells. The amount of total flavin was idenentical in both cells.
    3. The development of the respiratory activity during the cultivation in the ethanol-medium was inhibited by chloramphenicol and Actinomycin D, but not by Mitomycin C. Cells cultivated in the presence of spermine showed somewhat inhibited oxygen uptake. But it is not clear at present that it is due to the inhibition of the development of respiratory activity or merely to the inhibitory effect of spermine on respiration.
    4. The amounts of trehalose and mannan were identical in both the glucosegrown and the ethanol-grown cells, but glycogen was much higher in the glucosegrown cells.
    5. The activities of phosphorylase, glucose-6-phosphate dehydrogenase and phosphogluconate dehydrogenase were identical in both cells. The activities of glucose-6-phosphatase, ribosephosphate isomerase, lactate dehydrogenase and isocitrate: NADP oxidoreductase were higher in the ethanol-grown cells than in the glucose-grown cells.
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  • MITSUTO HASEGAWA, SHINJIRO OZAWA, YASUHIKO ANDO, HIDEYA SAKURAI, TOSHI ...
    1965 Volume 14 Issue 4 Pages 179-187
    Published: 1965
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    The influence of increased fibrinolysis on bleeding tendency was studied. In acute leukemia and aplastic anemia, the co-existence of high fibrinolytic activity and thrombocytopenia was frequently observed in hemorrhagic cases. In fibrinolytic state, the bleeding tendency was more prominent in thrombocytopenic animals. In microscopic studies of mesenteric vessels of the rabbits, no bleeding was found even after activation of fibrinolysis or thrombocytopenia was induced. When the small vessels were previously injured with mechanical or chemical stimuli, a massive hemorrhage ensued. It is concluded therefore that vascular injury is an important factor in the mechanisms of hemorrhage even in elevated fibrinolytic state and that thrombocytopenia enhances the fibrinolytic bleeding.
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  • YUJI SUEYOSHI, KAZUHEI EBINA
    1965 Volume 14 Issue 4 Pages 189-192
    Published: 1965
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
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  • HARUHIRO ANDO, NOBUMASA TANI
    1965 Volume 14 Issue 4 Pages 193-198
    Published: 1965
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    1) The influence of choline on the nonprotein respiratory quotient (R.Q.) was examined in the albino rats.
    2) The R.Q. in the 24-hour-fasted rats was 0.80, indicating that a significant amount of carbohydrate was still oxidized, whereas in the 48-hour-fasted rats the R.Q. was 0.71, indicating that fat was oxidized almost exclusively.
    3) When choline was injected to the 48-hour-fasted rats, protein catabolism was markedly depressed and the oxidation of fat was augmented.
    4) The administration of glucose raised the R.Q. to 0.90 in the 48-hourfasted rats. However, if these animals had received the injection of choline, the R.Q. was 0.68, indicating that the oxidation of carbohydrate was strongly inhibited and the oxidation of fat was augmented.
    5) The R.Q. in the 24-hour-fasted rats was 0.80 as described above, whereas that in the adrenalectomized or hypophysectomized rats was decreased to 0.72. It is evident from these results that the oxidation of carbohydrate was depressed in these animals.
    In consideration of the results obtained in the experiments by Okada6) and Nakata et al.7) which pointed out the inhibitory action of choline on the adrenocortical function, the inhibition of carbohydrate oxidation by the injection of choline as shown in the present experiment may be ascribed to the lowered adrenocortical function.
    6) Catabolism of protein in the 24-hour-fasted rats was decreased by the adrenalectomy and it was still decreased by the injection of choline.
    7) According to the above results, the injection of choline augments the oxidation of fat through its inhibitory action on the oxidation of carbohydrate and protein in the body. This effect of choline may be ascribed to the inhibition of the adrenocortical function. The data also indicated that choline inhibits the development of fatty livers without inhibiting the oxidation of fat as an energy source.
    The authors wish to express sincere thanks to Emeritus Professor Y. Sueyoshi for his unfailing guidance throughout the course of this work and in the preparation of this treatise.
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  • TAKAMURA MURAKI
    1965 Volume 14 Issue 4 Pages 199-211
    Published: 1965
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    1) Human skin surface film lipid was obtained by swab method with ether from 75 normal individuals from the newborn to those in the seventies of both sexes.
    2) Total fatty acid composition was analysed by gas chromatography on a polyester column.
    3) Variations of composition of fatty acids according to sex, age and parts of the body were analysed.
    4) Regional differences: -16.00 (palmitic and branched-chain unsaturated C16) and 18.00 (stearic and branched-chain unsaturated C18) acids were higher; 14.00 (myristic) and 16.50 (palmitoleic) acids were lower on the lower extremities than on the other parts of the body.
    5) Variations by sex. In adults, the male had a higher 16.50 (palmitoleic) acid content, and in adults above 50 years of age, the female had higher 18.00 (stearic and branched-chain unsaturated C18) acid content.
    6) Variations by age. 14.00 (myristic) and 16.50 (palmitoleic) acids showed changes parallel to the amount of skin surface lipid with some exceptions: they were lower in childhood, and higher after adolescence. The percentages of 18.00 (stearic and branched-chain unsaturated C18) and 18.44 (oleic) acids showed an inverse change by age: they were high in childhood.
    7) These changes of fatty acid composition of skin surface film lipid can be partly explained, at least, by considering them as the result of a different mixture ratio of lipids from epidermal and sebaceous gland origin.
    8) It was deduced that myristic and palmitoleic acids mainly originate from the sebaceous gland and oleic acid from the epidermal cells.
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