The Keio Journal of Medicine
Online ISSN : 1880-1293
Print ISSN : 0022-9717
ISSN-L : 0022-9717
Volume 15, Issue 1
Displaying 1-6 of 6 articles from this issue
  • WALTER STAHL, HISAKICHI MATSUBAYASHI, SHINKICHI AKAO
    1966 Volume 15 Issue 1 Pages 1-10
    Published: 1966
    Released on J-STAGE: May 26, 2009
    JOURNAL FREE ACCESS
    The course of an infection with the BEV strain of T. gondii was followed in splenectomized mice, and in cortisone-treated mice. It was observed that the pathogenesis of the disease was greatly altered in both groups of animals, geherally culminating in a fatal toxoplasmic ehcephalitis. Common findings were: symptoms of neurological disease, persistence of trophozoites in peritoneal exudate, suppression of immunity to reinfection, early appearance of cysts in the braih, development of many cysts in clusters, and evidehce of a strong inflammatory response in association with many of the cysts. These observations are interpreted as indicating that modification of the immune response to Toxoplasma was achieved, and that as a consequence of this modification, parasite proliferation in tissues and hematogenous transport of trophozoites to the brain continued uncurtailed, leading to the increasingly severe neurological involvement and the terminal encephalitis.
    The clusters of cysts are believed to be fortuitous gatherings, arising from the invasion of circumscribed areas of the brain by large numbers of blood-borne trophozoites, and the inflammation in response to the considerable cellular destruction wrought by the growing clusters of cysts.
    The unsatisfactory status of the serology of toxoplasmosis, due to the lack of a purified and defined antigen, is described as a major handicap to the elucidation of the nature and significance of the immune response to Toxoplasma.
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  • ICHIRO NAKAYAMA
    1966 Volume 15 Issue 1 Pages 13-21
    Published: 1966
    Released on J-STAGE: May 26, 2009
    JOURNAL FREE ACCESS
    Observations were made on the survival of high virulent RH strain inoculated intravenously into immune mice which had been infected with the low virulent Beverley or S-273 strain previously. Following results were obtained.
    1) Trophozoites penetrated into tissue cells in 85% of immune mice within 2 hours and 59% within 6 hours after the challenge. Even within 2 minutes many trophozoites were already found in tissues of lung. At this stage, however, only a few parasites were found in liver and spleen. The invaded parasites multiplied in tissues and no difference was seen as regards the invasion and subsequent multiplication between immune and control mice in this period.
    2) In immune mice, the trophozoites once multiplied in tissues began to decrease in number on the 3rd day from challenge and most of them suddenly disappeared on the 4th and 5th day, only a few being found in lung, spleen and liver. This state of infection continued up to 2 weeks after the challenge. Between 3 and 8 weeks after the challenge, only a few parasites were found in tissue preparations on rare occasions. On the contrary, a large number of parasites were found in tissues of control animals until one week after the challenge and they died of the infection within 10 days.
    3) It was demonstrated that organisms inoculated into immune mice were able to multiply in tissues at the early stage of challenge infection, but most of them were soon destroyed. A small number of parasites, however, were able to survive in tissues for a very long time.
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  • UTAKO OKAMOTO, YUMIKO TAKADA, AKIKAZU TAKADA
    1966 Volume 15 Issue 1 Pages 25-34
    Published: 1966
    Released on J-STAGE: May 26, 2009
    JOURNAL FREE ACCESS
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  • KANEO YAMADA, YUTAKA TSUCHIYA, BUNYA NAKAMURA
    1966 Volume 15 Issue 1 Pages 35-43
    Published: 1966
    Released on J-STAGE: May 26, 2009
    JOURNAL FREE ACCESS
    1) The total plasminogen proactivator units in 15 cases of hemorrhagic group showed higher value than those in 18 cases of control group.
    2) The deviation of proactivator pattern in hemorrhagic children from the normal pattern has been observed chromatographicaly.
    3) When PPA in pathological group is expressed as PPA ratio, this value approaches to the normal as age increases.
    4) In the remission stage of leukemia these ratios approached to the normal.
    From our results, the undifferentiatedness of children apparently can be demonstrated even in fibrinolytic system.
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  • TOMOMI SAKURADA
    1966 Volume 15 Issue 1 Pages 45-50
    Published: 1966
    Released on J-STAGE: May 26, 2009
    JOURNAL FREE ACCESS
    1) Nitrogenous compounds of the glucose-grown and the ethanol-grown yeast cells were investigated.
    2) Amounts of amino acids in amino acid pool and in RNA bound amino acids fraction were higher in the ethanol-grown cells. Hydroxy-amino acids and cystine were higher in the ethanol-grown cells than in the glucose-grown cells.
    3) Difference in amino acids composition was observed in peptide fraction. Cystine was higher and basic amino acids were lower in the ethanol-grown cells than in the glucose-grown cells.
    4) No difference in amino acids composition of protein fraction was observed between the ethanol-grown and the glucose-grown cells.
    5) It is concluded that nitrogenous compounds are influenced strongly by the compoistion of culture medium.
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  • TOMOMI SAKURADA, HIROKO MATSUMURA
    1966 Volume 15 Issue 1 Pages 51-53
    Published: 1966
    Released on J-STAGE: May 26, 2009
    JOURNAL FREE ACCESS
    1) Intermediates of heme biosynthesis and aminolaevulinate dehydratase of the glucose-grown and the ethanol-grown yeast cells were investigated.
    2) Aminolaevulinate dehydratase was higher in the ethanol-grown cells than in the glucose-grown cells.
    3) Porphobilinogen and coproporphyrin, among other intermediates of heme biosynthesis so far examined, were higher in the glucose-grown cells than in the ethanol-grown cells.
    4) It is concluded that glucose depresses soluble enzymes as well as mitochondrial enzymes responsible for heme biosynthesis.
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