The Keio Journal of Medicine
Online ISSN : 1880-1293
Print ISSN : 0022-9717
ISSN-L : 0022-9717
Volume 15, Issue 2
Displaying 1-5 of 5 articles from this issue
  • KANEO YAMADA, KIYOSHI INOUE, TOYOKO MIZUGUCHI
    1966 Volume 15 Issue 2 Pages 55-62
    Published: 1966
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
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  • KAZUYA YAMAMOTO, TAKAMURA MURAKI, IWAO FUKUI
    1966 Volume 15 Issue 2 Pages 63-66
    Published: 1966
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    New method for determination of blood antifibrinolytic activity by means of gel filtration was discussed.
    1) Fractionation of antifibrinolytically active components of blood was performed.
    2) There are two kinds of inhibitors to urokinase-activated fibrinolytic enzyme system in normal human serum, α-inhibitor and β-inhibitor.
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  • NOBUO YOSHII, MIZUO KAGAWA, YOSHIYUKI ISHIDA
    1966 Volume 15 Issue 2 Pages 67-81
    Published: 1966
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Comparing the EEG of normal individuals and of cases with superficial tumor of the brain, electroencephalographic survey in 79 cases of vertified deep cerebral and infratentorial tumor has been made.
    EEG abnormality responsible for deep tumors are composed of two signs, which appears in EEG tracing due to brain disease and appears in normal individuals with less severity and less frequency. If the former is denominated major sign, the latter will be minor sign. Major sign are consisted of 1) parasagittal homologous synchronous burst, 2) homologous bilaterally burst except parasagittal area, 3) shifting inter-hemispheric burst or burst like activity between homologous regions, 4) over all unihemispheric emphasis of wave amplitude decrease or voltage increase. Minor sign are 1) continuous or frequent bianterior amplitude predominance, 2) continuous or almost continuous appearance of anterior-posterior amplitude equalization, 3) low amplitude theta waves localized at bicentral region or the neighbouring area which appears much abandance comparing the normal persons.
    These signs are non specific, but significant manifestation of deep level disturbance. Only 79 cases are analyzed here and there is the paucity of the report dealt with minor signs. Therefore, further careful evaluation of these signs should be necessary.
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  • YASUO ICHIHASHI, TADAO OIKAWA, KIYOSHI INOUE
    1966 Volume 15 Issue 2 Pages 83-93
    Published: 1966
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    During recent years, erythromycin, which is generally thought to have little antibacterial activity against Gram negative intestinal bacteria in vitro, has been evaluated clinically as a rather effective antibiotic against bacillary dysentery. To clarify the mechanism of the effect of this antibiotic in vivo against bacillary dysentery, we attempted to compare the effect of oral administration of erythromycin upon the intestinal bacterial flora of experimental animals and human children with that of the other antibiotics; colimycin, kanamycin, aminobenzyl penicillin and tetracyclin, which are known to be effective against dysentery bacilli in vitro.
    To approach this problems, we examined the antibacterial activities of those antibiotics on nutrient agar, and SS agar, which contained bile acid as an ingredient.
    The different behaviour observed between E. coli and dysentery bacilli to erythromycin on SS agar but not on nutrient agar suggested the importance of specific conditions for a given species of bacteria to conduct antibacterial test in vitro.
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  • V. ANTIVIRAL EFFECT OF ISONICOTINYLGUANIDINE AND NIOOTINYLGUANIDINE
    TAKEO UEDA, SHIGESHI TOYOSHIMA, KANAME TAKAGI, YOSHIKO SETO, MASAKO TA ...
    1966 Volume 15 Issue 2 Pages 95-99
    Published: 1966
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    To find antiviral agents, a lot of guanido group containing compounds were synthesized and screened as to their antiviral effect. Among these synthesized compounds, the two compounds, Isonicotinylguanidine and Nicotinylguanidine, were found to be effective on some of picorna viruses. The site of the action of Isonicotinylguanidine was found to be the inhibition of the early step of intracellular multiplication of virus.
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