The Keio Journal of Medicine
Online ISSN : 1880-1293
Print ISSN : 0022-9717
ISSN-L : 0022-9717
Volume 15, Issue 4
Displaying 1-5 of 5 articles from this issue
  • Preliminary Report
    TATSUYUKI KUDO, NOBUO YOSHII, SHIRO SHIMIZU, SADAO AIKAWA, HIROSHI NAK ...
    1966 Volume 15 Issue 4 Pages 191-195
    Published: 1966
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
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  • HIDETOYO KOI
    1966 Volume 15 Issue 4 Pages 197-212
    Published: 1966
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Following oral administration of ergocornine metanesulphonate to thirtyeight women in the post-ovulatory period, the urinary excretion of steroids was measured.
    (1) Seven out of ten women, who received 2 mg, showed a fall in pregnanediol excretion after ergocornine administration, while the remaining 3 did show slight rise in its value. Seven out of 10 subjects treated with this ergot alkaloid of 10 mg revealed a drop on pregnanediol level. Three out of 5 cases who received 20 mg of this agent disclosed the similar result. The mean value of urinary pregnanediol excretion in women given 8mg (0.97mg/day) was definitely lower than that of the control group (1.64mg/day).
    (2) Six out of ten women showed increased urinary excretion of 17-KS following ergocornine and 4 out of 10 a rise in 17-OHCS excretion.
    (3) All of seven women had an apparent increase in urinary estrogen excretion following ergocornine administration.
    These results do not support Shelesnyak's hypothesis, that the effect of ergocornine might be due to a blocking of the enzyme 3 β-hydroxysteroiddehydrogenase which are essential for the endogenous production of progesterone.
    Following subcutaneous administration of pregnenolone-4 C14 to eight women in the post-ovulatory period, the urinary excretion of pregnanediol and its radioactivity was measured in urine specimens for 48 hours. Four out of these eight women were concurrently treated with 8mg of ergocornine and other four for the control.
    (4) The mean value of urinary pregnanediol level in the group treated with ergocornine was found to be lower, as compared with that of the control. There was no distinct difference, on the contrary, in the count per minute of C14 as pregnanediol between two groups.
    (5) The effects of this drug on the B. B. T. curve, uterine endometrium, the amount of cervical mucous and the vaginal smear index were also studied in women of normal mestrual cycles.
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  • YASUMASA MAJIMA
    1966 Volume 15 Issue 4 Pages 213-217
    Published: 1966
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    After albino rats were starved or fed with the fat and pyridoxine deficient diet, linoleic, linolenic and arachidonic acids and pyridoxine were administered. The amount of polyunsaturated fatty acids in phospholipid of the liver and muscle was then determined and the following results were obtained.
    1) Even if rats were fed on the fat deficient diet or starved, there were hardly any decreases of linolenic and arachidonic acids despite the decreases of linoleic acid in phospholipid.
    2) Under the existence of pyridoxine, linoleic, linolenic and arachidonic acids changed each other in phospholipid. In pyridoxine deficiency, linoleic acid failed to change into arachidonic acid, but arachidonic acid was changed in to linoleic acid.
    3) From the above mentioned results, it was suggested that arachidonic acid was metabolized into linoleic acid in phospholipid of white rats suggesting a possibility of a cycle formation between these two acids.
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  • NOBUO YOSHII, TSU-WEI TO, IKURO MURASE, RYUZO SHIOBARA, MIZUO KAGAWA
    1966 Volume 15 Issue 4 Pages 219-226
    Published: 1966
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    It seems to us that there has not been a paper about Average Reference Electrode Method since the publication by Goldman' and Offner2 in 1950. From the results mentioned above, comparing with MP, characteristics of Ave. R. are:
    (1) In many cases, localized EEG abnormality was more clearly represented.
    (2) As to non-focal EEG abnormality, records which are very useful to diagnosis can be obtained, except a extremely low amplitude brain potential.
    (3) Since Ave. R. did not use ear lobe as reference, the electrical activity in temporal region was easily observed, and artifact by abnormal electrical activity did not take place.
    (4) Physiological artifact was difficult to mix. On the other hand, alternative current artifact tended to slightly mix on some occasions. Since amplitude was represented lowerly than the case in which ear lobe was used as reference electrode, it is not suitable to record low amplitude.
    From those results, it can be emphasized that Ave. R. is much more helpful for localizing space taking lesion of the brain than MP. And we convince that accuracy of EEG diagnosis can be increased by using Ave. R.
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  • TAKASHI HAYASHI, TOSHIRO OTSUKA, SADAO AIKAWA, HIROSHI HOSHINO
    1966 Volume 15 Issue 4 Pages 227-243
    Published: 1966
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
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