The Keio Journal of Medicine
Online ISSN : 1880-1293
Print ISSN : 0022-9717
ISSN-L : 0022-9717
Volume 17, Issue 2
Displaying 1-5 of 5 articles from this issue
  • KIYOMICHI HANABUSA, HISAYO KOHNO
    1968 Volume 17 Issue 2 Pages 75-79
    Published: 1968
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
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  • KIYOO BEPPU
    1968 Volume 17 Issue 2 Pages 81-107
    Published: 1968
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
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  • SOME ASPECT FOR ETIOLOGY AND TREATMENT OF APLASTIC ANEMIA
    MITSUTO HASEGAWA, YASUO MATSUKI, SHINJIAO OZAWA, YASUHIKO ANDO
    1968 Volume 17 Issue 2 Pages 109-123
    Published: 1968
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    1) The plasma EP levels of patients with idiopathic aplastic anemia and other cases were measured simultaneously by the methods of Fried, Krantz and Matoth. EP titer in aplastic anemia was found to be higher when serum (plasma) was tested by the method of Fried (in vivo assay) and lower when tested by the methods of Matoth and Krantz (in vitro assay), although results were equal by any of the three method in all other cases.
    2) Causes of the different EP level in cases of aplastic anemia were dis-cussed.
    8) The bone marrow of patients with idiopathic aplastic anemia when tested in vitro revealed an increased incorporation rate in response to EP rich plasma as observed in the bone marrow of the normal individual.
    4) Treatment with EP rich plasma showed a remarkable effect on almost all patients with idiopathic aplastic anemia which did not respond to the normal plasma given as the control.
    5) Discussions whether or not EP if purified, will be a useful agent in the treatment of idiopathic aplastic anemia, were made.
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  • KANEO YAMADA, ZENZABURO YAMADA
    1968 Volume 17 Issue 2 Pages 125-133
    Published: 1968
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    1) Correlation between the amount of fibrinogen and value of FSF in plasma obtained from normal adults and children, newborn infants, and also in various disorders was examined.
    In the cases of hypofibrinogenemia showing less than 100 mg/dl, the value of FSF decreased to the level less than 25%. These remarkable cases consisted of consumption coagulopathy such as Kasabach-Merritt syndrome, promyelocytic leukemia etc. and liver diseases such as congenital atresia of bile ducts, cystic dilatation of common bile ducts, hepatitis etc.
    In spite of the strong correlation between these two factors in the extreme cases of pathological group it was also noted that the amount of fibrinogen re-mained normal in the cases of newborn infants showing physiological low level of FSF.
    2) Alteration in FSF value by the addition of cysteine in vitro was ob-served.
    a) In consumption coagulopathy, the value of FSF could not be restored by addition of cysteine.
    b) In liver diseases, the low value of FSF restored to the normal by cysteine.
    c) In newborn infants, although decreased values of FSF elevated to some extent by the addition of cysteine, their restoration did not reach to the level of healthy adults and children.
    Based on our findings, it is likely that, FSF in liver diseases exist mostly as a potentially active form, and in consumption coagulopathy, both active and potentially active forms have been consumed. In neonatal period, the produc-tion of these two forms are at the immature stage.
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  • 1968 Volume 17 Issue 2 Pages e1
    Published: 1968
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
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