1) Correlation between the amount of fibrinogen and value of FSF in plasma obtained from normal adults and children, newborn infants, and also in various disorders was examined.
In the cases of hypofibrinogenemia showing less than 100 mg/dl, the value of FSF decreased to the level less than 25%. These remarkable cases consisted of consumption coagulopathy such as Kasabach-Merritt syndrome, promyelocytic leukemia etc. and liver diseases such as congenital atresia of bile ducts, cystic dilatation of common bile ducts, hepatitis etc.
In spite of the strong correlation between these two factors in the extreme cases of pathological group it was also noted that the amount of fibrinogen re-mained normal in the cases of newborn infants showing physiological low level of FSF.
2) Alteration in FSF value by the addition of cysteine
in vitro was ob-served.
a) In consumption coagulopathy, the value of FSF could not be restored by addition of cysteine.
b) In liver diseases, the low value of FSF restored to the normal by cysteine.
c) In newborn infants, although decreased values of FSF elevated to some extent by the addition of cysteine, their restoration did not reach to the level of healthy adults and children.
Based on our findings, it is likely that, FSF in liver diseases exist mostly as a potentially active form, and in consumption coagulopathy, both active and potentially active forms have been consumed. In neonatal period, the produc-tion of these two forms are at the immature stage.
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