The Keio Journal of Medicine
Online ISSN : 1880-1293
Print ISSN : 0022-9717
ISSN-L : 0022-9717
Volume 18, Issue 3
Displaying 1-5 of 5 articles from this issue
  • AKIO SHINODA
    1969 Volume 18 Issue 3 Pages 115-128
    Published: 1969
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Fetal kidneys and placentas obtained from female mice of the DDN strain mated with male mice of the SWISS strain were transplanted to the abdominal walls of the DDN female mice in the following manner.
    Group A: the grafts were the fetal kidneys and the placentas, and the recipients were the mother mice.
    Group B: the grafts were the placentas, and the recipients were the mother mice.
    Group C: the grafts were the fetal kidneys, and the recipients were the mother mice.
    Group D: the grafts were the fetal kidneys, and the recipients were the unrelated pregnant mice.
    Group E: the grafts were the fetal kidneys, and the recipients were the virgin mice.
    In group A, B and C, the animals were sacrificed 28, 56 and 100 days after transplantation. In groups D and E, the animals were sacrificed 28 days after transplantation. The survival rates of grafts decreased as time passed. In group A, some placentas and kidneys and in C, some kidneys survived for 100 days. The placentas which were transplanted with kidneys, showed high sur-vival rate (44%) at 100th day, but the survival rate was much lower when the placentas were transplanted alone. The survival rates of fetal kidneys trans-planted to their mothers were higher than those of the kidneys transplanted to unrelated recipients, and pregnancy did not influence the survival rate. In groups C, D and E, necrotic and granulomatous lesions were far more frequently ob-served than in group A. It was concluded that not only fetal tissues would support placentas to survive but placentas would also support fetal tissue to survive.
    The helpful advice of Associate professor H. Sakaguchi, Keio University, is herewith acknowledged.
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  • TAKESHI KAWAI
    1969 Volume 18 Issue 3 Pages 129-145
    Published: 1969
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    The participation of histamine in bronchial asthma was studied.
    1. The averages of the plasma histamine concentrations of the asthmatic patients with positive skin reaction to the house dust (Group 1), with negative skin reaction (Group II), and of non-asthmatics (Group III) were 11.2, 10.3 and 12.9 mcg/L respectively (as to healthy individuals 12.5 mcg/L), and there were no differences in these groups. The histamine concentrations after in-cubation with the house dust in Group I, II and III were 18.7, 13.3 and 14.5 mcg/L respectively (as to healthy individuals 13.0 mcg/L). A significant his-tamine release was found in Group I, i.e. the asthmatic patients with positive skin reaction, while not in the other groups. This fact indicated that the house dust was the allergen to the asthmatic patients with positive skin reaction to the house dust.
    2. There was no correlation between the numbers of basophil and eosin-ophil leukocytes in each group.
    3. There was no correlation between the plasma histamine concentrations and the numbers of eosinophil leukocytes, so this denied the hypothesis that his-tamine could cause the eosinophilia.
    4. There was no correlation between the plasma histamine concentrations and the number of eosinophil leukocytes.
    5. In the asthmatic patients with positive skin reaction to the house dust, the decrease of the number of basophil leukocytes was recognized after incuba-tion with the house dust. The significant correlation between the amount of his-tamine released and this decrease was proved.
    6. The amount of histamine released with the challenge of the house dust proved decrease according to the desensitization therapy.
    The author is indebted to Professor J. Gomi and Lecturer T. Kimura for instruction and to Dr. Aoyagi and Dr. Y. Yamada for assistance.
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  • THE RIGHT VENTRICULAR CONTRACTION AND THE LOCAL MYOCARDIAL CONTRACTION MEASURED WITH TRANSCATHETER METHOD
    HARUO TOMODA, SHUNNOSUKE HANDA, TAKANORI OGINO, MASAKATSU FUKUDA, HAJI ...
    1969 Volume 18 Issue 3 Pages 147-152
    Published: 1969
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    The relations between the right ventricular contraction and the local myo-cardial shortening measured by means of the transcatheter method were dis-cussed. The local tension-velocity-length relationships were also shown.
    The authors wish to express their sincere gratitude to Prof. H. Sasamoto for his generous guidance and instruction in this study.
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  • YASUNOBU SUZUKI, HIROSATO MIYAKE, MAKOTO SAKAI, YUKIO INUYAMA, JUNICHI ...
    1969 Volume 18 Issue 3 Pages 153-162
    Published: 1969
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Bleomycin, discovered and developed by H. Umezawa in 1965, was adminis-tered to 50 patients with malignant tumors in head and neck. The doses and methods of administration were as follows : 10-15 mg-potency/day with intra-arterial infusion method, 10-30 mg-potency/day with intravenous injection and 15 mg-potency/day with local injection method. The effect of the drug was evaluated according to the changes of the tumors through gross observation in most cases. The remarkable effect was observed in 27.3% of intravenous in-jection group (the efficiency rate 59.1%), in 47.4% of intra-arterial infusion group (the efficiency rate 80%) and in 12% of local injection group. Side effects were rash, fever, stomatitis and anorexia, and these were appeared in 54% of the entire cases. No disturbance of the hematopoietic organs was observed.
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  • TETSUHEI OGAWA
    1969 Volume 18 Issue 3 Pages 163-173
    Published: 1969
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    The fine structure of the leukemic cells from seven cases of acute promy-elocytic leukemia was described, and compared with that of the promyelocytes from acute myeloblastic leukemia and the leukemic cells from monocytic leuke-mia.
    The fibrin-like structure, which has never been reported, was seen in the rough-surfaced endoplasmic reticulum of the leukemic cells.
    The common features of the leukemic cells of this type included well de-veloped rough-surfaced endoplasmic reticulum, lysosomes and Golgi apparatus, large mitochondria and fibrillar formation near the nucleus.
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