The Keio Journal of Medicine
Online ISSN : 1880-1293
Print ISSN : 0022-9717
ISSN-L : 0022-9717
Volume 19, Issue 1
Displaying 1-6 of 6 articles from this issue
  • YOSHIHIRO YAMADA
    1970 Volume 19 Issue 1 Pages 1-20
    Published: 1970
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    1. The binding rate of PAS to human serum albumin measured by the method of equilibrium dialysis correlate the albumin concentration and inversely correlate the PAS concentration in the range of 50 to 400 mcg/mI.
    2. The binding rate of PAS to human albumin is the lowest at pH 6.5 and increases according to the increasing alkalinity.
    3. Almost the same binding rates of PAS to serum protein are obtained either in vivo and in vitro by the method of equilibrium dialysis.
    4. There is an individual difference in the binding rates of PAS to serum protein even when corrected by the albumin concentration.
    5. The inverse correlation is proved between the blood level and the acety-lation rate of PAS.
    6. The inverse correlation is also proved between the binding rate and acetylation rate of PAS.
    7. There is a significant correlation between the unbound blood level of PAS and'the microbiologically active blood level of INH, and this result may suggest that the same grade of acetylation takes place in the same individual even when the different drugs are given.
    8. The serum protein binding is one of the most important factors of inactivation of the drug in vivo as well as the acetylation, and it may influence the clinical therapeutic effect of the drugs.
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  • YASUMASA MAJIMA
    1970 Volume 19 Issue 1 Pages 21-26
    Published: 1970
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Six triglycerides consisting of oleic and palmitic acid labelled with 14C were subjected to hydrolysis in vitro by rat pancreatic lipase and the radioisotope activity of the monoglyceride produced was determined. Comparison with un-hydrolyzed triglycerides was accomplished. Results show the partial exchange of long chain triglyceride was found to take place not only at the 1.3 position, but also preferentially at the position of the unsaturated fatty acid. The possibility of the coexistence of 2 kinds of rat pancreatic lipase, one changing triglycerides to diglycerides and the other changing the diglyceride to a monoglyceride was suggested.
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  • YASUMASA MAJIMA
    1970 Volume 19 Issue 1 Pages 27-30
    Published: 1970
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Albino rats fasted 48 hours were fed with 1-14C-oleicc acid, 1-14C-linoleic acid and 1-14C-palmitic acid, to daily determine the radioisotope activity of saturated fatty acid, monoenoic fatty acid, and dienoic fatty acid in the depot fat. Each fatty acid decreased to approximately the same degree. Changes in the radioisotope activity of monoenoic fatty acid were not influenced by the addition of linoleic acid. Based on these results, there appeared to be no differ-ence in the translation speed among palmitic, oleic and linoleic acid in depot fat.
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  • A COMPARATIVE WORK BETWEEN AGED, ADULTS AND CHILDREN
    NOBUO YOSHII, KIYOSHI MATSUMOTO, KINYA OSHIDA, TAKATO KAZUNO, TOSHIO S ...
    1970 Volume 19 Issue 1 Pages 31-46
    Published: 1970
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Divided 3, 284 patients of the head injuries into three age groups, the children, the adults, and the aged, and investigated the relationship of their clinical pictures, X-ray evidences, and EEG abnormality.
    1) EEG abnormality of the head injuries most frequently appeared in the children (49%), less frequently in the aged (35%), and least frequently in the adults (24%).
    2) As to the relationship between the consciousness disturbance and EEG abnormality, 10 mins interval of the unconsciousness became a borderline; the abnormal EEG more frequently appeared, when the unconsciousness was more than 10 mins.
    3) The diffuse abnormality frequently appeared in the children, and the frequent focal abnormality was found in the aged.
    4) About half of the patients of skull fracture showed the abnormal EEG.
    5) As to burst, theta waves frequently appeared in the children; alpha range wave in the adults; and delta waves in the aged.
    6) Spike, spike and wave complex, and sharp wave were mainly found in the children.
    7) The slowing trend like diffuse slow wave, posterior half slowing, and such was found in the aged.
    8) Slow wave of high amplitude like posterior half random δ, θ waves were found many in the children.
    9) Abnormal wave activated by the hyperventilation and photic stimulation was observed frequently in the children and rarely in the aged.
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  • KIYOAKI WATANABE
    1970 Volume 19 Issue 1 Pages 47-59
    Published: 1970
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Fibrinolytic activities of the leukemic cells collected from ten leukemic patients were studied and compared with those of normal leukocytes.
    Characteristic findings were observed in the spontaneous fibrinolytic activi-ties of these cells. The myeloblasts prepared from four AML patients and small lymphocytes from two CLL patients were lacks of this activity. In contrast, the azurophil granules of leukemic cells of one case of acute promyelocytic leukemia exhibited the elevated spontaneous fibrinolytic activity, which seemed to be approximately two times greater than the activity of normal leukocytes. Moreover, the fibrinolytic enzymes of these leukemic cells showed somewhat similar inhibitory effects on anti-proteases to α-chymotrypsin, but not to plasmin, trypsin and normal leukocytes. Namely, they were completely inhibited by salivary-kallikrein inhibitor (Trasylol) and soybean trypsin inhibitor but very slightly by t-AMCHA. CML neutrophils demonstrated the moderate fibrinolytic activity, which was almost equal to that of normal leukocytes quantitatively and qualitatively, and the enzymes of these cells appeared to be derived from the neutrophil granules.
    On the other hand, the proactivator activity by SK was equally observed in all examined leukemic cells, and that was thought to be localized mainly in the cell membrane. Like normal leukocytes, any type of leukemic cells did not possess other fibrinolytic enzymes such as the plasminogen-activator, the plas-minogen activated by UK and the anti-UK.
    The author wishes to express appreciation to Prof. Dr. J. Gomi (Medicine), Associate Prof. Dr. M. Hasegawa (Medicine) and Dr. H. Sugita (Medicine) for their interest and advice.
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  • MIZUO KAGAWA
    1970 Volume 19 Issue 1 Pages 61-65
    Published: 1970
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
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