The Keio Journal of Medicine
Online ISSN : 1880-1293
Print ISSN : 0022-9717
ISSN-L : 0022-9717
Volume 19, Issue 2
Displaying 1-5 of 5 articles from this issue
  • NOBUTAKE MATSUO
    1970 Volume 19 Issue 2 Pages 67-72
    Published: 1970
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Response of plasma insulin to intravenous glucose injection in the umbilical vein and artery were studied in normal newborn infants. Normal newborn infants produce a small rise in circulating insulin levels in response to hypergly-cemia despite a delayed excessive insulin levels in the umbilical vein. The relatively poor response of the neonatal pancreatic beta cells to glucose was confirmed.
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  • RYOKO SUZUKI
    1970 Volume 19 Issue 2 Pages 73-86
    Published: 1970
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    In order to investigate the metabolism of bile acids of the mouse by intestinal microorganisms, isolation of the organisms responsible for the transformation of bile acids in the intestinal tract of conventional mice and their activity in vivo in mono- or polycontaminated exgermfree mice were made.
    Bacteroides, Lactobacillus, Enterococcus and Clostridium perfringens isolated from the intestines of conventional mice converted conjugated bile acids into free acids both in vitro and in vivo, but E. coli, Staphylococcus and Proteus did not. These microorganisms capable of converting conjugates distributed in the whole intestines, also in the cecum and upper small intestine. Among the resident intestinal microorganisms of mice, only E. coli had the ability of converting cholic acid into 7-ketodeoxycholic acid. The role of exogenic microorganisms in the conversion of free bile acids were also investigated compared with resident intestinal flora. Many species of such exogenic bacteria as Shigella, Salmonella and El Tor vibrio had no effect on the conversion of cholic acid. Some of pathogenic E. coli converted cholic acid and some did not.
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  • SHOGO SASAKI, NOBUHIKO ONISHI, TAKEJI NISHIKAWA, RYOKO SUZUKI, RYOZO M ...
    1970 Volume 19 Issue 2 Pages 87-101
    Published: 1970
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
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  • TAKASHI AKAMATSU, MASATOMI OHBA, NORIYUKI NARAHARA, SUSUMU KODAIRA, MO ...
    1970 Volume 19 Issue 2 Pages 103-114
    Published: 1970
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    In major abdominal surgery, the restriction of oral nutrition and surgical trauma produce a marked loss of protein and, therefore, carbohydrate supply as an energic source by intravenous route is essential during this period. However, carbohydrate metabolism is impaired immediately after surgery. This is con-sidered to be due to the relative shortage of insulin action which reflects endocrine responses to surgical trauma. By estimating fluctuations of plasma glucose, free amino acids and insulin, in this study, the authors have mainly investigated the metabolic interrelationship between carbohydrate and amino acid during and after surgery, and some considerations regarding these conditions have been discussed.
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  • YASUHARU KUWAHARA
    1970 Volume 19 Issue 2 Pages 115-133
    Published: 1970
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    1. The author has devised a new ultrasonic phaco-emulsifler after a series of fundamental experiments.
    2. The aspiration method by the ultrasonci phaco-emulsifier was used in about 250 cataract patients, and clinical results of one hundred cases were re-ported.
    3. The clinical results were almost as good as the conventional cataract surgery.
    4. The author believes that the main advantages of this aspiration method of senile cataract are simplicity, safety and an early convalescence.
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