The Keio Journal of Medicine
Online ISSN : 1880-1293
Print ISSN : 0022-9717
ISSN-L : 0022-9717
Volume 19, Issue 3
Displaying 1-5 of 5 articles from this issue
  • KINYA OSHIDA, NOBUO YOSHII, KASHIWA MIKAMI, TOSHIO SAWA, KIYOSHI MATSU ...
    1970 Volume 19 Issue 3 Pages 135-143
    Published: 1970
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
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  • A POSSIBLE PATHOGENESIS OF MYOTONIC DYSTROPHY
    HIDEO WAKAMATSU, HARUO NAKAMURA, KIYOAKI ITO, WAKO ANAZAWA, SHIGETAKA ...
    1970 Volume 19 Issue 3 Pages 145-149
    Published: 1970
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    It has been reported that several inhibitors of cholesterol biosynthesis can induce myotonia, cataract and baldness, which are frequently observed in myotonic dystrophy, in man and experimental animals with concomitant accu-mulation of desmosterol.
    These observations suggest that the abnormal lipid metabolism play a pathogenetic role in myotonic dystrophy.
    The results of this study showed significantly elevated serum desmosterol, total cholesterol and triglyceride in myotonic dystrophy, indicating a possibility of pathogenetic role of abnormal lipid metabolism in this disease.
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  • YASUMASA MAJIMA
    1970 Volume 19 Issue 3 Pages 151-156
    Published: 1970
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Cholesterol-C14-oleate and cholesterol-C14-linoleate were administered in albino rats either orally through a catheter or by injection, to measure the specific activity of each fat in the serum, liver and depot fat in a chronological sequence.
    As a result, scarcely any radioactivity was demonstrated in triglyceride, diglyceride, monoglyceride, free cholesterol, free fatty acid, phospholipid fraction and depot fat (triglyceride) when injection was employed, unlike oral adminis-tration through a catheter. The fatty acid of the orally ingested cholesterolester is hydrolyzed within the digestive tract, absorbed and transferred to other fats. However, the fatty acid of cholesterolester injected into the body or synthesized in the body is probably not transferred to other lipids.
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  • YASUMASA MAJIMA
    1970 Volume 19 Issue 3 Pages 157-161
    Published: 1970
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Albino rats were maintained on a constant basic diet and fasted for 48 hours, to determine each lipid in serum lipoprotein for comparison with the value before fasting.
    As the result, triglyceride in low density lipoprotein appeared to have increased as compared with the prefasting level. Other fats increased only slightly. The fatty acid composition of the increased triglyceride was relatively quite similar to that of depot fat before fasting.
    The depot fat thus appeared to be transported during fasting, not in the form of free fatty acid but in the form of a low density lipoprotein, mainly triglyceride.
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  • MINORU TOMITA, FUMIO GOTOH
    1970 Volume 19 Issue 3 Pages 163-175
    Published: 1970
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    An electronic osmometer supplied with a rigid but leaky semipermeable membrane, and a semiconductor strain transducer was described. The leaky membrane so prepared responded rapidly to a colloid solution with reproducibil-ity of ± 1.7%. The continuous recording showed a monoexponential response up to a plateau followed by a gradual decrease. Our investigation showed that the maximum height of the plateau can be regarded as the product of the true osmotic pressure and the reflection coefficient, and that the reflection coefficient remained unchanged during repeated measurments. With this osmometer, it was possible to detect relative changes of osmotic pressure developed by a solute in water. After determining the reflection coefficient, native changs could be calibrated into absolute units of atm. Possible applications of the osmometer were described.
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