The Keio Journal of Medicine
Online ISSN : 1880-1293
Print ISSN : 0022-9717
ISSN-L : 0022-9717
Volume 2, Issue 1-2
Displaying 1-5 of 5 articles from this issue
  • ITTAKU MIKATA
    1953 Volume 2 Issue 1-2 Pages 1-22
    Published: 1953
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
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  • TAKASHI HAYASHI
    1953 Volume 2 Issue 1-2 Pages 23-38
    Published: 1953
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    1. If the faradization of a certain strength and duration was applied to the motor cortex of a dog, the epileptic seizure was produced which continued after the cessation of the application, and when the motor cortex was excised, the attack was suddenly ceased.
    2. When a minute quantity of nicotine, picrotoxine, pentamethylentetrazol in its diluted solution was introduced into the grey matter of the motor area of a dog, the epileptic seizure was produced and continued, and as soon as when the site of its application was excised, the attack was suddenly ceased.
    3. Acetylcholine in its rather high concentration which was applied to the motor area could produce the epileptic fit as the above chemicals in dogs as well as in human beings.
    4. Sodium glutamate if pure in its appropriate concentration also could produce from the motor cortex the fit of epileptic seizure in dogs as well as in human beings, but when it was mixed with proteinoids, those motor action was inhibited.
    5. When sodium glutamate was not pure, it was inactive in the above motor effect, but if it was treated for a few second in vitro by the electric current, direct or induced, it was suddenly disinhibited and produces the motor effect. The sodium glutamate was the only substance which would be activated by current in vitro.
    6. A model experiment was introduced and discussed by the author which suggested how electric current excited the motor nerve cells of extrapyramidal system. At the same time, a hypothesis on aetiological origin of epilepsy was offered.
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  • II. INFLUENCES OF ASSOCIATED BACTERIA AND THE DECREASE OF HOST-RESISTANCE UPON THE PRODUCTION OF THE ABSCESS
    BUYU YOSHIMURA
    1953 Volume 2 Issue 1-2 Pages 39-47
    Published: 1953
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    1) Entamoeba histolytica growing in culture media were washed with Ringer's solution by centrifugation to get rid of as many associated bacteria as possible and then they were added with pure culture of strepto- or staphylo-coccus. This mixture of amoebae and bacteria was inoculated directly into the liver of rats. Though abscesses were produced in many of the rats inoculated, amoebae were not found in them at all. As it was considered that the vitality of amoebae might be impaired by the washing with Ringer's solution, pure culture of strepto- or staphylococcus was added directly to the culture of amoebae without preliminary treatment with Ringer's solution. Inoculation of this amoebae-bacteria mixture also did not give a higher rate of the production of amoebic liver abscess as compared with control experiments.
    2) Injection of antibiotics after the inoculation much reduced the death of the experimental animals and abscesses produced were small in size and amoebae were found in none of them while in the control animals they were found in 30% of abscesses produced.
    3) Strains of amoebae associated with a single strain of Escherichia coli or Clostridium perfringens produced abscesses in rather a small percentage of animals inoculated and amoebae were detected in none of the abscesses.
    4) To reduce the resistance of host to pathogenic microbes, CCl or inulin was administered before or after the inoculation of amoebae. Definite effects of these substances were, however, not recognized partly due to the premature death of experimental animals.
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  • YOICHI YAMAGUCHI, SEIICHI ASANO, SHUN MATSUKI, SHOSHICHI HIWATARI, RYO ...
    1953 Volume 2 Issue 1-2 Pages 49-58
    Published: 1953
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
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  • YASUKAZU NISHIYAMA
    1953 Volume 2 Issue 1-2 Pages 59-74
    Published: 1953
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    1. Itried to modifize the Kossa's method and by the foregoing procedure in oxalic acid solution, contrived better method for demonstration of calcium deposits in tissue.
    2. With my new method and several histochemical procedures, it has been found that the fundamental matrix of pathologic calcification is mucopolysacchride degeneration.
    3. The mucopolysaccharides by influence of some tissue damage, are lost their colloidal property and precipitated or coagulated, this degeneration of muco- polysaccharides associate with ionized calcium or calcium salts in tissue fluid and form mucopolysaccharide calcium complex.
    As the ratio of calcium salts which are attracted from surrounding tissue fluid increase, the mucopolysaccharide part as fundamental matrix of calcifica- tion decreases its quantity, and then, is formed the complete inorganic calcium deposit.
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