The Keio Journal of Medicine
Online ISSN : 1880-1293
Print ISSN : 0022-9717
ISSN-L : 0022-9717
Volume 2, Issue 3
Displaying 1-4 of 4 articles from this issue
  • II. EFFECTS OF THE IMMUNIZATION WITH KILLED VACCINES ON SALMONELLA ENTERITIDIS INFECTION OF MICE
    DAIZO USHIBA, MORIMASA YOSHIOKA, RYUNOSUKE IWAHATA, SOROKU YAMAGATA
    1953 Volume 2 Issue 3 Pages 75-90
    Published: 1953
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Effects of the immunization with killed vaccines against the infection of mice with a virulent strain of S. enteritidis have been studied, special attention being given to analysing the infection into two categories, the large inoculum infection and the small inoculum infection.
    Prolongation in the survival time of animals, which indicates the protection against the primary septicemia caused by the large inoculum, was clearly demonstrated by the active immunization with killed vaccines prepared from culture types of salmonella which possess O antigens common to the challenge strain. Effects of the passive immunization against the large inoculum infection was observed in a similar result as in the active one, but to a lesser degree even though the pooled serum of immunized mice were used as the immunizing agent.
    The active immunization with a large amount of killed vaccines against the small inoculum infection (the typhoid and the secondary septicemia) was found somewhat effective, but there was no correlation between the effectiveness and the presence of O antibodies in the serum of immunized mice or of O antigens in culture strains used as the vaccine. No production of O antibodies for the challenge strain was noted at an early stage of the infection in the serum of mice immunized with a heterologous vaccine.
    All of T. T. T. (Hosoya), chrome vaccine (Ando), water-in-oil vaccine (Freund), and alum-vaccine showed no better immunizing effect against the small or large inoculum infections than the heat-killed vaccine.
    The seemingly “non-specific” immunity observed in the small inoculum infection was noted, though to a far lower degree, even in the large inoculum infection.
    Possibilities of the elucidation about this problem, taking the results of the past investigations with live vaccines into consideration, or in the connection with the immunity in other host-parasite systems, are discussed.
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  • SEIICHI ASANO
    1953 Volume 2 Issue 3 Pages 91-108
    Published: 1953
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
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  • III. EFFECTS OF ASSOCIATED BACTERIAL FLORA ORIGINATING FROM THE SAME AND DIFFERENT HOST SPECIES UPON THE PRODUCTION OF EXPERIMENTAL AMOEBIC LIVER ABSCESS
    BUYU YOSHIMURA
    1953 Volume 2 Issue 3 Pages 109-117
    Published: 1953
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    1) Cysts of Entamoeba histolytica in human stool were collected and made bacteria-free. To these cysts were added human and murine intestinal bacterial flora separately and cultivated. These cultivations were inoculated directly into the liver of rats. Amoebae associated with murine intestinal flora produced far more frequently the amoebic liver abscesses than those associated with human intestinal flora.
    2) By the injection of antibiotics following the inoculation of amoebae, abscesses produced were mostly minute in size and amoebae were detected from none of them.
    3) By the serial transplantation of amoebae from the abscesses into the liver of rats, the rate of the abscess production attained almost 100% and positive detection of amoebae from abscess also increased from one passage to another.
    4) Addition of the associated bacteria of this liver-passed, highly virulent strain restored much of the infectivity of a strain which had been maintained in the culture media for more than 18 months and had almost lost the infectivity to the rat liver.
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  • KAZUYO SHIMAI, KIYOHARU TAMARU
    1953 Volume 2 Issue 3 Pages 119-124
    Published: 1953
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
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