The Keio Journal of Medicine
Online ISSN : 1880-1293
Print ISSN : 0022-9717
ISSN-L : 0022-9717
Volume 20, Issue 1-2
Displaying 1-10 of 10 articles from this issue
  • DAIZO USHIBA
    1971 Volume 20 Issue 1-2 Pages 1-3
    Published: 1971
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
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  • TADAYOSHI KOBAYASHI
    1971 Volume 20 Issue 1-2 Pages 5-14
    Published: 1971
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    The bursa of Fabricius of wild birds, especially that of Passerine birds was investigated, and it was established that there are two types of structures in the mucous membrane, i.e., the plica type and the tubulus type. The development and structure of the lymph follicle in each type were discussed. Morphological correlation between the bursa and the cecum was observed, and these results were collectively arranged in a table. It was also mentioned that the variations of the structure of the BF should be taken into consideration in future when the function of the BF of birds are discussed.
    The author wishes to express his gratitude to Mr. Eiichi Sato, Akita Prefecture, for the sincere help in collecting the materials.
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  • TAKEHISA AKIYAMA, NOBORU YAMAURA, TAKIKO KENJO, TOSHIRO OHMURA, RYOZO ...
    1971 Volume 20 Issue 1-2 Pages 15-27
    Published: 1971
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
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  • HIROSHI YOSHIMATSU, TAKAAKI IKEDA, MASAHARU TSUCHIYA, KASHU SHIMABUKUR ...
    1971 Volume 20 Issue 1-2 Pages 29-43
    Published: 1971
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
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  • I. QUANTITATIVE STUDIES WITH SPECIAL REFERENCE TO MYASTHENIA GRAVIS
    SONOKO HABU, TORU KAMEYA, NORIKAZU TAMAOK
    1971 Volume 20 Issue 1-2 Pages 45-56
    Published: 1971
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    A quantitative study was performed regarding the occurrence and density of thymic lymphoid follicles in 125 cases of biopsied thymus in various diseases and 71 cases of autopsied subjects from accidental death.
    1. The incidence of thymic lymphoid follicles in myasthenia gravis was 83.8% and strikingly high in comparison with other diseases. Furthermore, in cases showing severe clinical symptom of myasthenia gravis, the incidence goes up to 100%.
    In hyperthyroidism the incidence of lymphoid follicles was high (66.7%), next to myasthenia gravis. The incidence in autoimmune disease excluding myasthenia gravis and hyperthyroidism was 39.1%. Follicular incidence in control thymus was very low (16.9%) as compared with Middleton's report.
    Lymphoid follicles were found very frequently in the thymic tissue of cases with thymoma associated with myasthenia gravis and Hashimoto thyroiditis, whereas no lymphoid follicles were observed in cases without such complications. The frequency of occurrence of thymic lymphoid follicles in women was similer to that in men.
    2. Thymic lymphoid follicles occurrec in a high frequency among aged people with myasthenia gravis and autoimmune disease, while occurrence of lymphoid follicles was restricted in the first and second decades in non-autoimmune disease and accidental death.
    3, The number of the thymic lymphoid follicles per lobule in myasthenia gravis was higher that in other diseases. There was a parallelism between the severity of muscle weakness and density of lymphoid follicles per lobule, although the correlative coefficient was not high.
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  • II. HISTOLOGICAL, HISTOCHEMICAL AND ELECTRON MICROSCOPIC STUDIES
    NORIKAZU TAMAOKI, SONOKO HABU, TORU KAMEYA
    1971 Volume 20 Issue 1-2 Pages 57-68
    Published: 1971
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Both histochemical and electron microscopic findings confirmed that thymic lymphoid follicles were identical in structure with lymphoid follicles in peripheral lymphoid tissues and not related to thymic epithelial cells. Histochemical demonstration of β-glucuronidase and other acid hydrolases showed that thymic medulla around the lymphoid follicles was infiltrated with the lymphocytes of the peripheral type corresponding to recirculating lymphocytes in paracortical areas of lymph nodes. Reticular cells around the thymic germinal center showed the same activity of alkaline phosphatase as those in lymph nodes.
    Electron micrographs revealed that the thymic germinal center contained reticular cells connected to each other with prominent interdigitation and desmosome-like structures. These cells differ from thymic epithelial cells in the absence of typical desmosomes, abundant tonofilaments and basement membranes.
    It could be assumed that reticular cells of thymic lymphoid follicles arise from mesenchymal cells of the perithymic tissue, and that the lymphocytes of the peripheral type occur in the thymus by mutation of thymic lymphocytes or by immigration of circulating lymphocytes.
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  • HIROSHI WATANABE
    1971 Volume 20 Issue 1-2 Pages 69-75
    Published: 1971
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    1. Ten cases in which the attached thymic tissues were histologically investigated from 91 cases of thymomas were reviewed with brief description of the gross appearance, histological findings and clinical complications.
    2. Thymic germinal centers were found in 7 cases of which 5 cases were associated with myasthenia gravis.
    3. One case of thymoma with the presence of a germinal center in the neoplastic stroma was added.
    4. The significant relationship between thymomas and thymic germinal centers is postulated with a discussion of the relationship of thymic abnormalities and autoimmune diseases.
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  • Report of 10 Cases and Follow-up Study
    KIYOTAKA KAMEGAYA, MASAHARU TSUCHIYA, KEN SAMBE
    1971 Volume 20 Issue 1-2 Pages 77-90
    Published: 1971
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    The present series include one case of chronic active hepatitis fulfilling the 5 markers for an autoimmune process, 25 2 cases of SLE, 3 cases of lymphoid thyroiditis and a case of hepatomegaly. Pneumomediastinography showed abnormally large thymic shadow and histological examinations revealed lymph follicle formation and/or marked hyperplasia of epithelial reticulum cells in all cases. The liver showed features of hepatitis ranging from non-specific reactive hepatitis to chronic active hepatitis. The presence of gamma-globulin in some cases was demonstrated in the germinal centers of the thymus with a fluoresceinlabeled antibody technique. A long-term follow up study has disclosed an improvement of the serum gamma-globulin level, the colloidal reaction and the latex fixation test and so forth. (A case of liver cirrhosis with hyperplasia of thymic epithelial reticulum cells and two cases of thymoma with liver cirrhosis and/or fibrosis were also recorded.)
    These findings would support the possibilities of a participation of thymic abnormalities or immunological processes in the development of some chronic hepatitis or cirrhosis.
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  • MASAHARU TSUCHIYA, KIYOTAKA KAMEGAYA, KASHU SHIMABUKURO, KEIZO TAKAGI, ...
    1971 Volume 20 Issue 1-2 Pages 91-102
    Published: 1971
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    The presence of parathyroid tissue within the thoracic thymus is not rare even in human beings. The authors have encountered such a finding in 18 out of 113 (15.9%) thymectomized adult cases via supra clavicular notch by Yoshimatsu's method. The intrathymic parathyroid tissue is well defined and encapsulated in most cases. However, on occasions, it is poorly defined or scattered and intermingled with thymic tissue thus being difficult to recognize. If, in case of hyperparathyroidism, parathyroid adenoma or hyperplasia is not found anywhere, intrathymic parathyroid tissue should be suspected. The authors experienced one such rare case, which is reported in the present paper.
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  • SHIRO FURUYA, SHOW BABA
    1971 Volume 20 Issue 1-2 Pages 103-114
    Published: 1971
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    1. Four cases of parathyroid cysts and one case of cervical thymic cyst were seen in our hospital during 8 years of observation.
    2. Diagnostic criteria was discussed to rule out the secondary change of cystic formation.
    3. Comparative studies indicated that both cysts seemed to develop congenitally from the thymopharyngeal duct system. 4. Both cysts were considered to be a rare entity. However, it may be possible to find them more frequently if sections of histopathological specimens are carefully taken from various sites.
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