The Keio Journal of Medicine
Online ISSN : 1880-1293
Print ISSN : 0022-9717
ISSN-L : 0022-9717
Volume 22, Issue 4
Displaying 1-4 of 4 articles from this issue
  • A Preliminary Report
    YUICHIRO GOTO, HARUO NAKAMURA, YOSHIYA HATA, NORIAKI NAKAYA, ICHIRO TA ...
    1973 Volume 22 Issue 4 Pages 143-149
    Published: 1973
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    To overcome the difficulties in the dietary treatment of hyperlipidemias, the method of food exchange table for hyperlipidemia has been developed, in which each food of 80 calories was handled as one unit and the cholesterol and fatty acid content in one unit of food were shown as number of black circle(s) and triangle(s). Each full black circle indicated 50 mg of food cholesterol, and a full triangle meant that S-1/2P value of food was 0.5. The patients were instructed to take daily diet containing not more than 5 black circles or +4 trangles in the total. Serum cholesterol and triglycerides of the patients thus instructed were compared with those of patients on ordinary dietary regimens. Although this method still failed to effect statisfactory reduction in serum lipid concentrations, the method made it easier for a dietician to explain the dietary regimen and also for a patient to observe dietary treatment. For further improvement, more strict exchange rules for varieties of food had to be established without causing imbalance in the nutritional ingredients of dietary regimens.
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  • MASAAKI NAKAZONO, KENKICHI KOISO, KUNIYOSHI TAJIMA, PAUL S. MALCHESKY, ...
    1973 Volume 22 Issue 4 Pages 151-162
    Published: 1973
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Ideal blood access devices for hemodialysis should have a blood contact surface similar to vascular intima and a tissue contact surface similar to tissue and an air contact surface similar to skin if the access device is placed exterior to the body. If these conditions are met, it was thought that both standard type shunts and artificial fistulae, similar to the surgically created fistula, could be designed with the same approach.
    Bovine mesentric arteries were chosen for the blood access device con-straction. Two general shemes of blood access devices were conceived: the sub-cutaneous (a modified Cimino-Brescia fistula) and the extracutaneous shunt. The results of preliminary study will be discussed in this report.
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  • PART 1. THE QUALITATIVE STUDY
    HIROKAZU NAITO
    1973 Volume 22 Issue 4 Pages 163-171
    Published: 1973
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Following the various lesions in the cerebral cortex of the monkeys, the degenerated fibers were traced in the level of the cerebral peduncle, pons and pyramid of the medulla oblongata. Extensive intermingling of the projection fields is demonstrated at the cerebral peduncle but there is a denser aggregation of the face fibers toward the medial side, arm fibers in the middle and foot fibers toward the lateral side of the middle 3/5 of the cerebral peduncle.
    The parietopontine tract passes at the lateral 2/5 of the pes pedunculi. In the pons, the parietopontine tract is rather concentrated in the dorso-lateral groups of the longitudinally descending bundles. Otherwise further extensive intermingling of the fibers occurs in the pontine level and no clear cut somatotopographical pattern is found.
    In the medullary pyramid, the degenerated fibers are diffusely and homogenously distributed. Small numbers of fibers in the motor face lesion still descend beyond the medullary pyramid. It was found that the pyramidal tract fibers were not clearly demarcated topographically in the brain stem as described in the diagram of some literatures.
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  • SHIGEO MATSUYAMA, KIYOMICHI HANABUSA
    1973 Volume 22 Issue 4 Pages 173-180
    Published: 1973
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Three isozymes of pig glycogen phosphorylase in the skeletal muscle, cardiac muscle and brain were studied mainly by means of electrofocusing. The isoelectric point of isozyme I, II and III located at pH 5.5, 5.9 and 6.35, respectively. Among these enzymes, isozyme III was found to be changed iso-electric point (pH 6.25) in contact with ammonium sulfate solution, and this changed protein appeared as a satellite-peak of native isozyme III peak. Pro-perties of the satellite-peak (isozyme III') were investigated comparing with native isozyme III. The results were as follows:
    (1) No difference on the catalytic properties between the two enzyme was observed except that specific activity of isozyme III' was lowered than that of isozyme III.
    (2) Isozyme III' still kept a dimer structure.
    (3) Isozyme III' could be converted to form “a” with phosphorylase kinase.
    (4) The reactivity of SH groups with DTNB was studied on both enzymes. It was shown that isozyme III' had one more reactive SH group per monomer which had been masked on the native enzyme.
    It was suggested from these results that conformational change occurred in the site which did not have significant effect on the active and ser-P sites.
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