The Keio Journal of Medicine
Online ISSN : 1880-1293
Print ISSN : 0022-9717
ISSN-L : 0022-9717
Volume 24, Issue 1
Displaying 1-4 of 4 articles from this issue
  • WITH SPECIAL REFERENCE TO THE COMPARISON BETWEEN HEAD INJURIES IN ADVANCED AGE AND THOSE IN MIDDLE AGE
    NOBUO YOSHII, KINYA OSHIDA, SAKAE FUKUDA
    1975 Volume 24 Issue 1 Pages 1-9
    Published: 1975
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Comparative studies have been done on the results of our EEG examination with 218 senile patients with head injuries and 1, 110 middle-aged patients with head injuries, who were classified into groups by the frequency of abnormal EEG records, duration of unconsciousness, notable clinical symptoms, skull fracture, and details of EEG findings. The principal findings out of the results were that the frequency of abnormal EEG was usually higher in senile patients concerning all groups, and especially that the frequency of abnormal EEG was nearly double in the patients with duration of unconsciousness for more than 10 minutes. Among the details of EEG findings, delta burst, focal abnormality, and slow waves in posterior half of the brain were the most notable findings.
    It is a matter of course that the head injuries of senile patients offer features different from those of young and middle-aged patients. The difference can be partly attributed to that the skull protecting the brain is fragile and that the elasticity of soft tissues is also reduced in the senile patients. The cerebral tissues are destined to become fragile as the neural fibers and blood vessels of neural cells get older.1-4 On the other hand, it has been pointed out that both the blood flow in the brain and the metabolism of cerebral tissues are reduced as the sclerosis of cerebral arteries is advanced, 5 and that these changes, when affected by the external forces exerted upon head, would indicate clinical pictures and results of laboratory examinations unlike those of head injuries in the young and middle-aged patients. The present report, therefore, has been intended for comparative evaluation of head injuries of senile patients with those of younger patients and, consequently, for clarification of the characteristics of head injuries in senile patients.
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  • SAKAE SAKURAI, MASAHIRO TAKAHASHI, YASUO NAKAJIMA, TOSHIO ISHIZAKA
    1975 Volume 24 Issue 1 Pages 11-17
    Published: 1975
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    The case of a 3 year 2 month-old girl with a history of multiple papil loma and unsuccessful surgical treatments' is reported in this paper. Micro surgery of the larynx and local injection of Bleomycin produced an effective result, however, and phonation was close to normal after 3 local injections. There has been no reccurrence for one year after this last procedure, and the patient is considered to have been cured.
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  • CONCENTRATIONS OF THE CHEMICAL IN THE ELUTION FROM DISHES OF FORMALDEHYDE RESIN IN SOME VEGETABLES
    KENZABURO TSUCHIYA, YOSHIO HAYASHI, MITSUKO ONODERA, TAKAO HASEGAWA
    1975 Volume 24 Issue 1 Pages 19-37
    Published: 1975
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    The study composes of the following experiments:
    1) The first experiment was carried out in order to calculate the lethal dose (LD50) of formaldehyde and of formalin solution.
    2) The second one was to examine the quantitative method and to measure the concentration of formaldehyde in solution eluted from plastic bowls made of formaldehyde resin.
    3) In the final experiment formaldehyde in some foods was measured. Principal results obtained were as follows:
    1) LD50 of formaldehyde by oral administration was determined to be 500-800mg/kg for rats.
    2) The maximum allowable concentration of the chemical for chronic poisoning was estimated to exist at the level of around 25 to 30 mg/day/50 kg for man.
    3) However, it was conceivable that various kinds of food would contain formaldehyde as high as almost 20 ppm. More elaborate studies are required on this point.
    4) It was confirmed that formaldehyde is eluted from plastic dishes and bowls made from a monomer of formaldehyde from the non-detectable concentration at 400°C up to 20 ppm at 90°C, and up to almost 400 ppm in solution of 4% acetic acid of 90°C, showing only 10 ppm at 40° to 50°C, after leaving the solutions in the bowls for 15 minutes.
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  • ROLE OF HISTAMINE IN CHRONIC LIVER INJURY
    KOHDOH ISHII, OSAMU SUZUKI, YASUYOSHI KIRYU, MASAHARU TSUCHIYA
    1975 Volume 24 Issue 1 Pages 39-47
    Published: 1975
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Role of autotallergic mechanism on the chronicity of liver diseases with special reference to histamine, which is said to be one of the chemical media tors and plays a large part in antigen antibody reaction, was investigated experimentally.
    Under the administration of homologous liver antigen with histamine to rabbits, liver injury closely resembling chronic active hepatitis could be de veloped, which progressed into liver cirrhosis with pseudolobulus formation. This result may indicate that the progression of chronic hepatitis into liver cirrhosis can be regarded as one process. Estrogen promotes antigen anti body reaction and plays a large part in prolongation and aggregation of liver diseases. Furthermore, liver cell carcinoma was demonstrated in one animal and epithelial hyperplasia of bile ductules in two animals. This fact may sug gest that chronic hepatitis changes into malignant tumor and perpetual anti genic stimulation has a large role in the development and progression of malignant tumor and role of histamine should never be ignored.
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