The Keio Journal of Medicine
Online ISSN : 1880-1293
Print ISSN : 0022-9717
ISSN-L : 0022-9717
Volume 26, Issue 2
Displaying 1-6 of 6 articles from this issue
  • Interrelationships in food and feces and interactions in the liver and the renal cortex
    SOICHIRO IWAO
    1977 Volume 26 Issue 2 Pages 63-78
    Published: 1977
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    The concentrations of Cd, Pb, Cu and Zn in food, feces and organs were analyzed in order to study the interrelationships among these metals in humans. Correlation coefficients and the ratio of all 4 metals in these media were calculated, and the following results were obtained: the ratios of Cd to Cu and Cd to Zn in the renal cortex showed 100 times higher and those ratios in the liver showed 10 times higher than those in food and feces. How-ever, Pb/Cu and Pb/Zn ratios did not vary in these media. Intimate correlations between Cd and Zn were found in the organs in spite of the fact that they showed no correlation in food and feces. Cu and Zn indicated high correlations in food, feces and renal cortex, but not in the liver. Thus this study indicates that the proportions of the metals ingested via food and excreted in feces are almost the same, i.e., the absorption rates are not greatly different. However, once absorbed, the relationships among the metals are markedly altered, suggesting different metabolism by individual metal and/ or possibly metal-metal interactions in the human organs, particularly in the renal cortex and the liver.
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  • YUKIO INUYAMA, KAZUYUKI ASAOKA, YASUO NAKAJIMA, MASATOSHI HORIUCHI, KE ...
    1977 Volume 26 Issue 2 Pages 79-89
    Published: 1977
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    The antibody against viral capsid antigen (VCA) of Epstein-Barr virus (EB virus) has been studied in 59 patients with malignant tumor of the nasopharynx, in 117 patients with tumor of the other sites of the head and neck, and in 263 patients with nonmalignant disease. The anti-VCA titer was determined by Kawamura's modification of Henle's indirect immunofluorescence technic.
    The geometric mean titer was 1:794 and the antibody positive rate (≥ 1:640) 82% in patients with nasopharyngeal tumor, while being 1:190 and 37% respectively in those with tumor of the other sites of the head and neck. In 263 patients with nonmalignancy serving as controls, the values were respectively 1:120 and 20%. The anti-VCA titer in patients with naso-pharyngeal carcinoma was significantly higher than that in controls by ridit analysis.
    The anti-VCA titer was repeatedly determined in patients with naso-pharyngeal carcinoma at different points of the clinical course.
    As the result of the present study, it was shown that in cases of recur-rence or metastasis there was a remarkable elevation of the anti-VCA titer and in cases of short and long term remission there was a decrease in the titer.
    We concluded that the anti-VCA titers might serve as a useful clinical parameter for prognosis of the nasopharyngeal carcinoma.
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  • TOYOMI FUJINO
    1977 Volume 26 Issue 2 Pages 91-98
    Published: 1977
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    A new microsurgical closure of the soft cleft palate was done in ten cases. The essence of the surgical procedure is summarized in three points; 1) a pancaked shaped musculomucosal flap of the soft palate and if necessary mucoperiosteal flap of the hard palate, 2) a whole layer Z-plasty at the palatopharynge:l muscle region, and 3) muscle sling of the levator veli palatini muscle. This surgical approach never exposes the retromolar region, which is a growth center, nor severes the lesser palatine nerve. Therefore, we expect a better growth of the maxillary and palatal bones, and less chance of anesthesia of the soft palate and of atrophy of the mucosal gland.
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  • HARUTOSHI KIZAKI, TOMOMI SAKURADA
    1977 Volume 26 Issue 2 Pages 99-104
    Published: 1977
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    The effect of starvation for 24 and 48 hours on the enzymes of purine nucleotide catabolism, i.e. 5'-nucleotidase, AMP deaminase, adenosine deami-nase, purine nucleoside phosphorylase, xanthine oxidase and guanase, has been examined with the mouse liver extract. Among them, 5'-nucleotidase activity increased by about 2 times after 24 and 48 hours of starvation. AMP deaminase decreased by about 18 and 12% after 24 and 48 hours of starvation, respectively. Adenosine deaminase increased by about 9 and 20% after 24 and 48 hours of starvation, respectively. On the other hand, purine nucleoside phosphorylase, xanthine oxidase and guanase activities did not change sig-nificantly. It is concluded that acute starvation may cause the imbalance of purine nucleotide metabolism in the liver.
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  • DAIZO TSUKUMO
    1977 Volume 26 Issue 2 Pages 105-123
    Published: 1977
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    We tried to determine the localization of reversible impairment of brain function in a percussion model of head injury. In our experiments, 30 cats were immobilized and artificially ventilated. Traumatic impact was adminis-tered by a sudden input of water into the epidural space at the right parietal region. Using EEG, SER, VER, and ECG as indexes of brain function, we evaluated traumatic effect. Intensity of impact showed closer correlation with change of SER than with change of EEG or VER. Impact first caused re-duction and flattening of polysynaptic components of SER. When impact was intensified, all components of SER were flattened and EEG was desyn-chronized. Immediate post-impact VER had a simple form, but soon returned to pre-impact form. From these indexes, we estimated that in this percussion model, the function of the lower brain stem was most vulnerable to impact. In about half of cases, suppression of lower brain stem function transiently reappeared at 10-15 minutes into recovery. When impact was much more intensified, SER remained flat throughout observation. EEG and VER re-covered fairly even in cases with continuously flat SER.
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  • HARUTOSHI KIZAKI, TOMOMI SAKURADA
    1977 Volume 26 Issue 2 Pages 125-134
    Published: 1977
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Purine phosphoribosyltransferases were assayed in crude extracts of mouse liver, spleen, kidney, heart, lung, cerebrum and red cells, which also contain xanthine oxidase, guanase, 5'-nucleotidase and adenosine deaminase, by the method which was based on the isolation of the products by electro-phoresis on cellulose acetate membrane. Purine phosphoribosyltransferase activities were found in all tissues examined. Among them, the activities in the cerebrum were higher than those of other tissues whereas activities in the red cells were very low. The activity ratios of hypoxanthine-guanine phosphoribosyltransferase with hypoxanthine and guanine as the substrates to adenine phosphoribosyltransferase were 0.9-2.1 and 1.8-4.1, respectively, in the liver, spleen, heart, lung and kidney. In the cerebrum these were 7.4 and 19.2, and were 0.2 and 0.2 in the red cells. The significance of these results has been discussed.
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