The Keio Journal of Medicine
Online ISSN : 1880-1293
Print ISSN : 0022-9717
ISSN-L : 0022-9717
Volume 27, Issue 1
Displaying 1-5 of 5 articles from this issue
  • TAKAO HARASHINA
    1978 Volume 27 Issue 1 Pages 1-13
    Published: 1978
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Experimental use of alcohol-preserved allo or hetero graft vessels to interpose arterial or venous deficit which are about 1mm in external diameter and less than 2.5cm long was performed. The preservation method is simple and inexpensive and the preserved grafts could be used almost permanently.
    The results were the same as one would expect from autografts.
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  • HIROSHI NAKAMURA, KAZUO MATSUSHITA, MAKOTO HATA, HIROSHI SAKAGUCHI
    1978 Volume 27 Issue 1 Pages 15-21
    Published: 1978
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    The potentially serious side effects that result from prolonged prednisolone (or prednisone) therapy are well known in clinical renal transplantation. The present study was undertaken to evaluate the effect of less toxic corticosteroid therapy on canine renal allograft. Fifty-three dogs received renal allografts from randomly selected donors. They were assigned into four groups and were treated as follows: group 1, controls, no immunosuppression; group 2, prednisolone, 3mg/kg/day, as conventionally used steroid; group 3, beta-methasone, 0.3mg/kg/day; group 4, paramethasone, 1.5mg/kg/day. Drug therapy was started two days before operation. The blood urea nitrogen (BUN) and serum creatinine were followed twice a week. An autopsy was performed in each dog. The kidney's histopathologic changes were arbitrarily graded in severity, and the graded lesions summed to give a final score for each sample. Beta-methasone has proven the most effective for both renal function and histology of the transplant. The results suggest that beta-methasone could replace part of prednisolone as immunosuppressive agent in renal transplantation, but that paramethasone was ineffective at the dosages studied.
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  • AKIRA ONO
    1978 Volume 27 Issue 1 Pages 23-36
    Published: 1978
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
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  • HISAO TACHIBANA, TORU MINE, TOMOAKI SASAKI, MASAHARU NARA, KOHEI ONO
    1978 Volume 27 Issue 1 Pages 37-42
    Published: 1978
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    A case with three intracerebral hematomas detected by computed tomography is reported. These regions were the left thalamus, the subcortex of the left parietal lobe and the right caudate nucleus-internal capsule. At surgery, two hematomas were observed in the left cerebral hemisphere, but the presence of tumor could not be recognized macro and microscopically.
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  • SEIICHI INAYAMA, TETSUICHI SHIBATA, JUN'ICHI OHTSUKI, SHIGEJI SAITO
    1978 Volume 27 Issue 1 Pages 43-46
    Published: 1978
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    A microanalytical method for the determination of hydroxyproline in a microquantity of connective tissues (0.05-5mg) has been developed on the basis of Prockop's conventional methods. The new method is simple, rapid, sensitive, and linear in a wider assay range (0.04-20μg), with a high reproducibility even when used by experts or novices. The present communication mainly describes the standard assay procedure of the method (protocol), which has been brought about by essential modification of the conventional method.
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