The Keio Journal of Medicine
Online ISSN : 1880-1293
Print ISSN : 0022-9717
ISSN-L : 0022-9717
Volume 28, Issue 2
Displaying 1-4 of 4 articles from this issue
  • YU MARUYAMA
    1979 Volume 28 Issue 2 Pages 63-72
    Published: 1979
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Cartilage provides various important structural supports, such as a sur-face for a bony joint, framework for the ears, nose, respiratory tract, and anterior chest cavity, where it is present in the greatest quantity.
    Cartilage is known to possess very little regenerative activity, but recently it has been noted that the perichondrium may have the ability to produce cartilage.
    During the investigation of the perichondrium, the possibility of enzyme-histochemical behavior was noted and was seemed to be regenerating cartilage from perichondrium. To date no experimental work on regeneration of cartilage from perichondrial and perichondrocutaneous island flap has been described.
    In author's experimental studies, chondrogenic activity apparently exists over wide age groups. The amount and shape of cartilage produced by any type of perichondrial graft is influenced by age, and the blood supply to the perichondrium in rabbits.
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  • HIROSHI OGAWA, KOJI KAMI, TOSHIO SUZUKI, TADAO MITSUI
    1979 Volume 28 Issue 2 Pages 73-79
    Published: 1979
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    The localization of lysozyme (LZM) in the human nasal mucoua was ob-served with the use of an unlabelled antibody peroxidase-antiperoxidase (PAP) method. LZM was distributed in serous cells of the nasal submucosal glands. Weak staining occurred in some mucous parts of them which seemed to be so-called seromucous cells classified by Shackleford and Wilborn, which exhibit intermediate characteristics between mucous and serous cells. In the present study, however, it was not clarified whether LZM produced by the serous cells is from blood plasma. No specific staining for LZM was detectable in the epithelial cells. Some tissue blood element cells such as neutrophils and macro-phages also contained antigenic LZM intracellularly in parallel with those of human blood huffy coats.
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  • YUKIO NAKAMURA, BAI-KWANN TU, KENICHI SHIMIZU, NAOMICHI KAWAMURA, KIYO ...
    1979 Volume 28 Issue 2 Pages 81-96
    Published: 1979
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Thirty-seven patients with documented PCO were studied. Group 1 patients had elevated luteinizing hormone (LH) and group 2 patients had normal LH. Among the patients of group 1, polycystic type of the ovary was the gross finding and 83.9% ovulation rate after ovarian wedge resection were noted, while the patients of group 2 were found to have sclerotic type of the ovary with 16.1% postoperative ovulation rate. Serum basal levels of LH, estrone (E1) and 11-deoxy-17 ketosteroid were significantly higher (p<0.01) before wedge resection but follicle stimulating hormone (FSH), estradiol (E2), estriol (E3) and testosterone (T) were within normal limits. After wedge resection, 11-deoxy-17 ketosteroid declined significantly (p<0.05), the levels of serum T, E1, E2, and E3 showed decreasing tendency without statis-tical significance and the results of luteinizing hormone releasing hormone test remained unchanged. The hypothesis of “locus minoris resistentiae” was speculated for the mechanism of ovulation induction following wedge resection.
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  • SHINICHI KOHSAKA, YASUZO TSUKADA
    1979 Volume 28 Issue 2 Pages 97-108
    Published: 1979
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Neurochemical changes and discriminative learning ability were investi-gated on experimental phenylketonuric rats (PKU rats). PKU rats were fed a diet containing 7% L-phenylalanine from 22nd day of age for several months. Some rats were fed the high phenylalanine diet from 22nd day of age up to 3 months of age, and thereafter they were fed a normal diet for appropriate period (Rehabilitated PKU rats).
    Gain in body weight was clearly lowered in the PKU and Rehabilitated PKU rats (R-PKU rats), but the DNA content per cerebrum did not differ from that of the controls. The concentration of 5-hydroxytryptamine (5-HT) and 5-hydroxyindol acetic acid (5-HIAA) in the cerebrum decreased sig-nificantly in the PKU rats, while the R-PKU rats showed normal values. The activity of 2', 3'-cyclic nucleotide 3'-phosphohydrolase (CNPase) decreased sig-nificantly in the cerebrum of the PKU and R-PKU rats. Operant brightness discriminative learning ability of the PKU and R-PKU rats was found to be disturbed compared to that of the controls.
    It was suggested that the poor learning ability in the PKU rats was more closely related to the dysmyelination in the cerebrum than other neural elements such as DNA and monoamine contents.
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