The Keio Journal of Medicine
Online ISSN : 1880-1293
Print ISSN : 0022-9717
ISSN-L : 0022-9717
Volume 34, Issue 3
Displaying 1-5 of 5 articles from this issue
  • MITSUHIRO OSADA
    1985 Volume 34 Issue 3 Pages 139-151
    Published: 1985
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Since the first success to close the cleft palate with muco periosteal flap by von Langenbeck, many improvements were made not only the technique but speech therapy, orthodontic treatment and anesthesiology.
    The author makes a review on the history of the cleft palate operation, and present concepts on the treatment of the cleft palate from the standpoint of the speech results and maxillary growth. Ten years ago, the surgeon made operation only to gain good speech results, but now he must think of maxillary growth at the same time.
    It is now fell known, that the early operation (1-2 years old) with mucoperiosteal flap results mal development of the maxilla. In eastern Europe, late operation (after 3-4 years old) are in common. But in western Europe, United States and Japan early operation is still prevailing. Several methods were reported which could preserve maxillary growth, yet problems remain in the speech. The author wish to introduce these methods, including his two stage method (Osada method).
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  • HIROSHI MURAKAMI, YASUO IKEDA, KUNIHIKO SATOH, KEISUKE TOYAMA, KIYOAKI ...
    1985 Volume 34 Issue 3 Pages 153-159
    Published: 1985
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    We have developed a simple and sensitive enzyme linked immunosorbent assay (ELISA) to detect antibodies against the platelet major glycoproteins, GPIb and GPIIb/IIIa complex. Briefly, the glycoproteins were immobilized in the microtiter wells by addition of Nonidet P 40 lysates of human platelets to the wells coated with mouse monoclonal antibodies against either GPIb or GPIIb/IIIa complex. Serum from patient was added to each well and antibody bound to the glycoproteins was detected by peroxidase conjugated goat anti-human IgG.
    Sera from 4 out of 43 patients with ITP were found to have antibodies against GPIb, while sera from 2 out of 43 had antibodies against GPIIb/IIIa complex. Analysis of clinical as well as laboratory characteristics of the patients failed to demonstrate any significant features that would distinguish the patients with the anti-glycoprotein antibodies from those without.
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  • A CASE STUDY
    JUNHAKU MIYAMOTO
    1985 Volume 34 Issue 3 Pages 161-166
    Published: 1985
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    An alternative approach by thyrotropin-releasing hormone (TRH) stimulation test to assess the prognostic factor was described in a patient with trophoblastic disease. The serial changes in the prolactin (PRL) responses to TRH administration after evacuation of molar tissue were similar to those of normal term pregnant, immediate postpartum and nonpregnant women. The thyroid-stimulating hormone (TSH) response to TRH was, however, absent for over 3 weeks after evacuation. The lack of TSH response may reflect the high thyrotropic activity of human chorionic gonadotropin (hCG). It might be feasible that the occurrence of a hCG plateau after evacuation can be predicted by the absent TSH response to TRH administration in patients with trophoblastic disease.
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  • MASAAKI TACHIBANA, J. W. CHIAO, BERNARD I. WEINSTEIN, GEORGE R. NAGAMA ...
    1985 Volume 34 Issue 3 Pages 167-178
    Published: 1985
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Cytolytic activity derived from conditioned medium (CM) of activated normal human peripheral blood lymphocytes was analyzed, using human solid tumor cells of kidney, bladder, breast and normal fibroblasts. Supplementation of CM to cell cultures resulted in an overall cytolysis, seen in cell number, cell growth, and colony formation. The lysis of cells was ascertained by the release of both lactic dehydrogenase and incorporated [3H] thymidine from the cells, to a degree which is directly proportional to the amount of cytolytic activity used and the length of exposure. The initial effect was revealed after one day and showed a greater than 85% cytoreduction by Day 3. The mechanism of cytolysis was further analyzed using human SK-RC-29 cells, which are suitable as target cells for the study of human cytolytic activity. CM was found to increase membrane permeability 6- to 8-fold by the flow cytometric determination of the permeability of a fluorescing DNA stain into the cells. The membrane permeability increase was seen prior to cell lysis, indicating its relationship to the destruction process. The cytolytic activity is non-dialyzable, heat stable at 60°C, and is distinct from human gamma interferon. Both T and B lymphocytes were shown capable of providing the cytolytic activity accompanied by increased membrane permeability.
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  • N. H. ANTIA
    1985 Volume 34 Issue 3 Pages 179-183
    Published: 1985
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    The Indian surgeon Sushruta described in 600 BC several operations for the correction of deformities including those of the nose and ears. In 1784 a potter demonstrated the Indian forehead rhinoplasty to two British Army Officers which has been well documented. The midline forehead (Indian) rhinoplasty on a remarkably narrow pedicle turned through 180° has been used successfully by us and documented in the British Journal of Plastic Surgery.
    Plastic surgery was revived in India in the late fifties by a few Indian plastic surgeons trained in the United Kingdom. The Association of Plastic Surgeons of India was formed by seven surgeons in December 1957 and the late Sir Harold Gillies was present and elected an Honorary Member. Gillies visited India twice and helped promote the speciality in our country.
    Today the Association of Plastic Surgeons of India have over 200 members with about 15 full-fledged centres of plastic surgery. Much original work has been undertaken by these surgeons especially for endemic problems like leprosy, filariasis and burns.
    India with a population of over 700 million needs a much larger number of centres for such surgery but due to limited financial resources much of this type of surgery has to be undertaken by the much larger group of general surgeons in the smaller district and country hospitals. The role of plastic surgeons is therefore to devise simple procedures and teach them to general surgeons and other specialities and restrict their work to the more major problems requiring their specialized skills and facilities. Also to undertake research in the prevention and treatment of deforming diseases like leprosy, cutaneous leishmaniasis, cancrum oris and filariasis.
    Many of the deformities are the result of communicable diseases some like small-pox have been totally eradicated. Besides these there are also the congenital deformities, burns, accidents and cancer particularly of the oral cavity as a result of tobacco chewing.
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