The Keio Journal of Medicine
Online ISSN : 1880-1293
Print ISSN : 0022-9717
ISSN-L : 0022-9717
Volume 37, Issue 4
Displaying 1-8 of 8 articles from this issue
  • So Inoue, Tetsuro Kubota, Takashi Ohishi, Masahiko Kuzuoka, Shoichi Ok ...
    1988 Volume 37 Issue 4 Pages 355-364
    Published: 1988
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    The antitumor spectra of quinocarmycin citrate (KW-2152; QCM), a novel antibiotic with a different molecular structure from conventionally available antitumor agents, was examined using a human tumor xenograft-nude mouse system. One breast (MX-1), one colon (Co-4), seven gastric (St-4, St-15, St-40, SC-2-JCK, SC-6-JCK, Exp-4 and H-111) and two lung small cell (Lu-24 and Lu-130) carcinomas were inoculated into BALB/cA male nude mice, and the treatment was initiated when the tumor started exponential growth. When QCM was given ip in schedules of 2.5mg/kg qd×14, 5mg/kg qd×7, 7mg/kg g3.5d×5 and 10mg/kg q7d×3 for MX-1 and SC-2-JCK, the most effective schedule of administration was 5mg/kg qd×7, which was applied for the other strains. QCM showed excellent antitumor activity against MX-1 and Co-4 which are sensitive to most conventionally available antitumor agents. The antitumor spectra of QCM against human lung small cell carcinomas was obvious; all of the Lu-130 tumors disappeared completely and five out of six Lu-24 tumors also disappeared. The efficiency rate of QCM against gastric carcinomas was 71.4% (5/7), which was almost equivalent to those of mitomycin C and cisplatin and superior to those of adriamycin, 5-fluorouracil, nimustine and aclarubicin. Because the antitumor spectrum of this agent against gastric carcinoma xenografts was excellent, it was thought to he useful for clinical application to gastric carcinomas.
    Download PDF (379K)
  • Seijiro Okusawa
    1988 Volume 37 Issue 4 Pages 365-378
    Published: 1988
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    In an attempt to elucidate the etiology of postoperative metabolic alkalosis in surgical patients, the exogeneous bicarbonate load as an etiologic factor was assessed in a prospective study. Also, the renal handling of bicarbonate was studied in postoperative patients. Seventeen patients who had a stomach cancer were randomly divided into two groups before operation. During the postoperative days zero through seven after gastrectomy, bicarbonate was continuously infused through intravenous fluid in group A, while no bicarbonate was given in group B. Citrate in fresh frozen plasma was interpreted as being a bicarbonate load with its nature of metabolic change to bicarbonate. Seven (78.5%) of the nine patients in group A exhibited postoperative metabolic alkalosis, which might have been caused by the retention of exogenous bicarbonate in the kidneys. On the other hand, no incidence of postoperative metabolic alkalosis occurred in group B. With regard to the renal handling of bicarbonate after operation, the rate of renal tubular bicarbonate reabsorption correlated closely to the bicarbonate retention in the kidneys, and was further regulated by sodium-cation exchange in the renal tubules. The blood aldosterone concentration had little effect on the tubular bicarbonate reabsorption. On the contrary, the rate of urinary bicarbonate excretion was indicated as not being determined by a homeostatic mechanism which responded to the systemic pH or blood bicarbonate level. Thus, the increased retention of exogenous bicarbonate followed by an enhanced renal sodium reabsorption under surgical stress was strongly suggested as the mechanism of uostoperative metabolic alkalosis induced by exonenous bicarbonate load. This implies that reevaluation is needed on the routine use of alkalinizing agents in intravenous fluid administration following surgery.
    Download PDF (506K)
  • Yasuhiro Soma, Kozo Kawada, Tadashi Inoue
    1988 Volume 37 Issue 4 Pages 379-385
    Published: 1988
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Whether the site of operation for coarctation of aorta has grown or not after resection and end-to-end anastomosis is an important factor to affect long term results, as an operation takes place in infancy in most cases. However, because aortography is necessary to know the growth exactly, clinical investigations are scarce. Excluding one case of recoarctation and the other with no sufficient data at the operation, we were able to confirm growth at the anastomotic site in 7 cases. Therefore, we believe that resection and end-to-end anastomosis is a useful technique as a surgical treatment of coarctation of aorta without sacrificing the subclavian artery and using prosthesis.
    Download PDF (817K)
  • Masahiro Kawaida, Hiroyuki Fukuda, Shigeru Kano, Shigeji Saito
    1988 Volume 37 Issue 4 Pages 386-397
    Published: 1988
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    The aim of this study is to evaluate the dynamic movement of the air tract fluid which is involved in the lubrication of the larynx by using excised canine larynges and experimental air tract fluid. The experimental phonation was artificially produced by blowing air from the trachea. From the results obtained, it is thought that the lubrication of the larynx during phonation might be carried out in three different phases; at the start of phonation (PHASE-1), during phonation (PHASE-2), and after the completion of phonation (PHASE-3).
    Download PDF (2815K)
  • Daisuke Aoki
    1988 Volume 37 Issue 4 Pages 398-414
    Published: 1988
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Phenotypic aspects of glycoconjugates in human endometrium were examined in association with the menstrual cycle and malignant transformation by horseradish peroxidase (HRP)-labeling method using seven different lectins as a probe. At the light microscopic level, Concanavalin A (ConA), Ricinus communis agglutinin (RCA), and wheat germ agglutinin (WGA) stained almost all glandular cells in both normal endometrium and endometrial adenocarcinoma. Dolichos biflorus agglutinin (DBA) and soybean agglutinin (SBA) demonstrated markedly enhanced binding in secretory endometrium compared with endometrium in the proliferative phase. Ulex europeus agglutinin 1 (UEA-1) strongly stained endometrial adenocarcinoma, especially the well differentiated type, but scarcely stained normal endometrium. The reaction with peanut agglutinin (PNA) was characterized by cytoplasmic staining in the carcinoma cells, whereas its binding was restricted to the apical surface in the normal cells. At the electron microscopic level, the reaction products representing UEA-1 and PNA binding sites were observed in the plasma and Golgi membranes of malignant cells. DBA stained the same membranes in the normal endometrium, with the number of positive cells being markedly increased in the secretory phase. Whereas ConA binding was proved to be positive in the plasma membrane, endoplasmic reticulum, Golgi apparatus and nuclear envelope of normal and malignant cells. These results indicate that sugar components of endometrial glycoconjugates change during the menstrual cycle and differ between normal endometrium and endometrial adenocarcinoma.
    Download PDF (3852K)
  • Takashi Kiyoizumi
    1988 Volume 37 Issue 4 Pages 415-428
    Published: 1988
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Hematoma formation is a frustrating complication of free skin grafting. Application of a low level diode laser to hematomas stimulates absorption with no side effects or scarring as presented in two clinical cases. Despite these satisfactory results little is known about the photobiological mechanism of the laser itself. In an in vitro study the author presents two photobiological effects of the low level diode laser. First, it stimulates PGI2 secretion in cultured human endothelial cells. PGI2 known as prostacyclin, has an anti-aggregatory effect on platelets and strong vasodilating properties. This increase of PGI2 in laser treated groups enhanced hematoma absorption. Second, the diode laser degradates the 125I labelled fibrin net by mechanical action. Continued research of the mechanism of the low level laser will expand the applications of laser treatment in the field of plastic surgery.
    Download PDF (2765K)
  • Masahiro Kobari, Naoki Ishihara, Kazuta Yunoki, Osamu Togashi, Shuzo S ...
    1988 Volume 37 Issue 4 Pages 429-433
    Published: 1988
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    A case with anomalies of the intracranial arteries, i.e. triplication of the middle cerebral artery associated with fenestration of the anterior cerebral artery, is reported. The terminology, clinical relevance and etiology of these anomalies are discussed.
    Download PDF (936K)
  • Hong-Ming Cheng
    1988 Volume 37 Issue 4 Pages 434-440
    Published: 1988
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    There are two modes of NMR (nuclear magnetic resonance), i.e., MRI (magnetic resonance imaging) and MRS (magnetic resonance spectroscopy). MRI is now a common diagnostic modality, which in many ways proves superior to X-ray CT. MRS can provide metabolic information of tissue, which is not obtainable with other diagnostic imaging means; its clinical application is in the offing. We have applied several NMR techniques to the examination of ocular tissues such as the lens, cornea, vitreous, and retina. These techniques include MRI of water protons (including NMR microscopy) and MRS of various nuclei such as phosphorus-31, carbon-13, deuterium, and proton. The results are summarized in this review.
    Download PDF (286K)
feedback
Top