The Keio Journal of Medicine
Online ISSN : 1880-1293
Print ISSN : 0022-9717
ISSN-L : 0022-9717
Volume 39, Issue 2
Displaying 1-9 of 9 articles from this issue
  • Tadashi Inoue, Kozo Kawada, Yasuhiro Soma, Ryohei Yozu, Takahiko Misum ...
    1990 Volume 39 Issue 2 Pages 69-74
    Published: 1990
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    We have proposed calling dissecting aortic aneurysm with entry of the dissection in the aortic arch “arch-type”. We described the procedures and results of surgery for 12 cases of this disorder. The dissection was localized (type a) in six cases, and extended (type b) in the other six. Seven cases were treated by patch or direct closure of the entry, with one operative death and two later deaths. Five cases were treated by reconstruction of the ascending aorta and the aortic arch with a prosthetic graft, with two operative deaths and one later death. Efforts must be directed towards improving the outcome of the latter operation.
    Download PDF (739K)
  • Wolfgang E. Berdel, Shinichiro Okamoto
    1990 Volume 39 Issue 2 Pages 75-78
    Published: 1990
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    There is considerable evidence that certain ether lipids such as 1-0-octadecyl-2-0-methyl-rac-glycero-3-phosphocholine represent a new class of antineoplastic agents. These ether lipids have been shown to be cytotoxic for a wide variety of tumors. The site of action of ether lipids appears to be the cell membrane, where they inhibit the biosynthesis of phosphatidylcholine as well as the activity of protein kinase C. However, it remains uncertain that these effects represent the only mechanism for the cytotoxic action of these ether lipids. Further experiments to elucidate the molecular mechanisms of the cytotoxic action of these compounds are necessary. Clinical phase I pilot trials have been completed showing encouraging tumor response in a small number of patients treated. Some of these ether lipids are selectively cytotoxic to leukemic cells sparing of normal cells within a certain dose range. Thus, they are uniquely suitable for purging residual leukemic cells from remission marrow used for autologous bone marrow transplantation. A phase I/II study of autologous bone marrow transplantation in acute leukemia using bone marrow cells treated with ether lipids is in progress.
    Download PDF (378K)
  • Hidetsugu Saito, Toshio Morizane, Tetsu Watanabe, Tatehiro Kagawa, Shi ...
    1990 Volume 39 Issue 2 Pages 79-85
    Published: 1990
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    To investigate hepatitis B virus (HBV) biology in vitro, the transfection of recirculized HBV DNA into Chang cell line was performed. Linear HBV DNA was isolated from recombinant HBV DNA, pHBR105, which includes the whole genome of HBV and was recirculized. Chang cells were transfected with this recirculized HBV DNA by the two different procedures of calcium/phosphate coprecipitation and electroporation. After the transfection, the presence of large nucleated cells with multinuclei and ground-glass cytoplasma were noticed and these cells seemed to proliferate faster than untreated Chang cells. Transient expression of hepatitis B virus surface antigen (HBsAg) was demonstrated in cytoplasma of transfected cells by indirect immunofluorescence. HBsAg was not detected in the culture supernatants by radioimmunoassay. The extra-chromosomal HBV DNA was detected in the transfected cells by both procedures 7 weeks after the transfection by Southern blot analysis but it was lost 4 weeks after that. It was demonstrated that it was possible to transfect Chang cells with HBV DNA and that DNA was functioning to express HBsAg transiently.
    Download PDF (542K)
  • Etsuyo Takayama, Hiroyuki Fukuda
    1990 Volume 39 Issue 2 Pages 86-90
    Published: 1990
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    The intracordal injection technique was first introduced by Brünings in 1911. This technique has been accepted as vocal rehabilitation for dysphonia caused by deficiencies of glottal closure. Although various injection materials have been evaluated, the injection procedure itself has not been studied. In this study, we measured the mechanical force required to perform intracordal injection by using a certain amount of substance, when varying the needle size and syringe type. Although a large needle can reduce the mechanical force for injection, leakage from the pinhole can not be prevented. We modified this technique by introducing a CITO JECT, a syringe, which is used for the anesthesia of the periodontal ligament, to perform the collagen injection. With this technique, the mechanical force required for the injection can be reduced to 1/2 to 1/4 of the force by the conventional technique. We conclude that the introduction of this syringe enable us to use the needle with smaller diameter to facilitate the intracordal injection.
    Download PDF (2029K)
  • Joji Inomata, Kosuke Yamazaki, Ryuzo Tsuji, Masatoshi Kobayashi, Tutom ...
    1990 Volume 39 Issue 2 Pages 91-96
    Published: 1990
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    The number of juvenile delinquents detained by police for shoplifting, glue sniffing, and automobile and bicycle theft reached its highest level in Japan in 1980 since world war II. The incidence of delinquency has fluctuated up and down somewhat between 1981 and 1988 but has remained slightly below the 1980 peak. In 1988 the number of juvenile detainees between the ages of 14 and 18 was 187, 172. Juvenile delinquents currently undergoing training and treatment at the K-Institute in Kanagawa Prefecture will be discussed. The K-Institute for the training and correction of juvenile delinquents is a public institution which was established in 1900. It has a holding capacity for 100 male offenders. We have interviewing and treating inmates by psychotherapeutic and psychopharmacological methods since 1975. The institute has recently begun to practice a form of inclusive family therapy where the parent comes and stays with the child in the institute for a short period of time. The treatment program has shown a success so that so far none of the participants have returned to the institute, while 30% of non-participants have returned to the institute.
    Download PDF (2618K)
  • Ken Marumo, Masaru Murai, Nobuhiro Deguchi, Kouichi Ikeuchi, Hiroshi T ...
    1990 Volume 39 Issue 2 Pages 97-101
    Published: 1990
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Immunologic and antitumor effects of human recombinant interferon-gamma were studied in patients with renal cell carcinoma. A daily dose of 6 to 12×106 units/m2 of interferon-gamma was given by intravenous drip infusion or intramuscular injection to nine patients over a period varying from two to 16 weeks. Antibody-dependent cell-mediated cytotoxicity and OKIal-positive monocytes count increased significantly after the therapy was started. Interferon-gamma transiently increased OKT3- and OKT4-positive lymphocyte count. Tumor regression was not observed when clinical response was evaluated in seven patients. Two others, who had no measurable metastases, were not evaluated, because interferongamma were given to them as post-operative adjuvant therapy. Our results indicate that interferongamma stimulated monocytes and enhanced cell-mediated cytotoxicity; they also suggest the necessity of combining monoclonal antibodies and other biological response modifiers that effect tumor-associated antigens.
    Download PDF (307K)
  • Hiroyuki Fukuda, Masahiro Kawaida, Kazuaki Oki, Shigeru Kano, Yoshihis ...
    1990 Volume 39 Issue 2 Pages 102-105
    Published: 1990
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    The phonatory examination was performed while monitoring vocal fold vibration by laryngostrobovideography. Vocal fold vibration was video-taped by a laryngostroboscope and flexible laryngofiberscope inserted through the nasal cavity. Simultaneously, the phonatory examination was conducted with a phonation analyzer. The data were entered into a personal microcomputer via an A/D converter and analyzed to obtain the parameters of sound pitch, sound intensity and mean expiratory air flow volume, which were superimposed on the color video monitor screen.
    Download PDF (1706K)
  • Tetsuo Nagai, Eisaku Susami, Tsutomu Ebihara
    1990 Volume 39 Issue 2 Pages 106-111
    Published: 1990
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Plummer-Vinson syndrome has been brought tp attention as a precancerous lesion of hypopharyngeal and cervical lesions of the esophagus, but that involving the stomach is uncommon. We report a case of Plummer-Vinson syndrome with gastric cancer. A brief literature review of this disorder is presented, and possible causes in this unusual case are discussed.
    Download PDF (1855K)
  • Ren Jun, Pan Borong, Li Mingfeng, Lu Ping, Yan Peisong, Miao Jiyan, Do ...
    1990 Volume 39 Issue 2 Pages 112-116
    Published: 1990
    Released on J-STAGE: March 27, 2009
    JOURNAL FREE ACCESS
    Biopsy samples were taken endoscoplcally from the of 693 patients with peptic ulcer and chronic gastritis presenting dyspepsia symptoms. Campylobacter pyloridis cultures were positive in 59 of 98 (60.2%) cases and histopathologically the organisms were found in 411 of 693 cases (59.3%). Pathologically, Campylobacter pyloridis was positive in 273 out of 300 patients with chronic superficial gastritis (91.0%), in 102 of 249 patients with chronic atrophic gastritis (40.9%), in 36 out of 144 patients with chronic atrophic gastritis with intestinalization or dysplasia (25.0%). We found that there was a significant association between the presence of Campylobacter pyloridis and chronic superficial gastritis, also the degree of lymphocyte infiltration showed a strong inverse association with the presence of Campylobacter pyloridis, suggesting that a local immune response might exert an important action in the eradication of this organism. These findings support the view that Campylobacter pyloridis, may be etiologically related to chronic gastritis and peptic ulceration, even though its role still remains to be determined.
    Download PDF (1235K)
feedback
Top