The Keio Journal of Medicine
Online ISSN : 1880-1293
Print ISSN : 0022-9717
ISSN-L : 0022-9717
Volume 4, Issue 1
Displaying 1-5 of 5 articles from this issue
  • KYUHEI NAKADATE, SHINNOSUKE YASOSHIMA, KOZO HOSHI
    1955 Volume 4 Issue 1 Pages 1-7
    Published: 1955
    Released on J-STAGE: May 26, 2009
    JOURNAL FREE ACCESS
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  • ESPECIALLY ON THE FORMATION MECHANISM OF THE CHANGE
    HARUO MATSUYAMA
    1955 Volume 4 Issue 1 Pages 11-24
    Published: 1955
    Released on J-STAGE: May 26, 2009
    JOURNAL FREE ACCESS
    Pathological changes of the central nervous system in Encephalitis Japonica were studied in 53 autopsy cases collected during 1948-1951. Special attention was given to the pathogenesis of the glial nodules and the necrotic foci, and to the localization of these changes within the central nervous system. The results are as follows:
    1. The most characteristic pathological picture noticed in the earliest stage of infection is the eosinophilic necrosis of nerve cells. This change is considered to result from the proliferation of the virus in these cells and not from circulatory disturbances.
    2. Most of the glial nodules develop on the basis of neuronophagia. A few are localized on one side or around the blood vessels with no relationship to nerve cells. This latter change suggests a probable proliferation of Japanese encephalitis virus in the endothelial cells of the blood vessels and is supported by finding similar changes in other viscera.
    3. Careful examination of minute nocrotic foci reveals a necrotic nerve cell in the center of these lesions. These minimal units of necrosis may coalesce and form the most commonly encountered military-sized necrotic foci.
    4. Neuronophagia, glial nodules and necrosis which are the fundamental changes noticed in Japanese encephalitis are considered secondary to the necrosis of nerve cells. As these changes are characteristic for viral infections, it would seem possible that the development of these three changes are due chiefly to the proliferation of virus in the nerve cells, to its diffusion in the surrounding tissue and to its toxic action.
    5. The degree of necrosis corresponds to the intensity of the primary infection, varying from focal areas of softening infiltrated by many scavenger cells, to cavernous formations, leaving behind many holes.
    6. As these fundamental changes depend on the existence of nerve cells, almost no changes are seen in the white matter. Furthermore, the intensity of the secondary changes varies greatly in accordance with the degrees of damage to the nerve cells and the distribution of the lesions varies accordingly.
    7. The selective involvement of certain nerve cells. cannot be explained by their morphological character alone, but it is considered possible that the internal composition of the nerve cells influences the proliferation of the virus.
    I hereby wish to express my deep gratitude to Prof. Teisho Aoki for his cordial guidance.
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  • MASAKATSU IZAKI, YUTAKA KIMURA
    1955 Volume 4 Issue 1 Pages 27-33
    Published: 1955
    Released on J-STAGE: May 26, 2009
    JOURNAL FREE ACCESS
    Angioma senile was statistically observed in a total of 1802 people, of which 1552 were males and 250 females. The results obtained were as follows:
    It is one of the skin changes which are due largely to age, its occurrence incidence gradually increasing as ages advance. Its occurrence is already seen rather frequently in the late teen-agers, the incidence in this group being (Occurrence incidence/Confidence limit: Upper limit-Lower limit), and it is especially noticed after 40 years of age, the incidence after 40 years being in male, and in female. The spots increase in number, after the fourth decade the majority showing two or more spots.
    No difference was found in sex incidence.
    It is most frequently noticed on the breast, next the back, and third the abdomen. Also, it is occasionally seen on the upper arm and the thigh. It may also appear on the neck and nape, face, head. However, it is rarely notieed on the leg and lips. In adolescence it is mostly seen on the breast and the back, and as ages advance it is likely to appear on the abdomen.
    We would like to acknowledge indebtedness and express gratitude to Dr. Yokoyama, Professor of Dermatology, School of Medicine, Keio University for assisting and encouraging us during the course of this study. We also desire to acknowledge the courtesy of Instructor Dr. Sato, School of Medicine, Keio University for his pains-taking aid and helpful suggestion.
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  • OBSERVATION IN HUMAN SUDDEN DEATH CASES AND EXPERIMENTAL STUDIES
    SABURO KATO
    1955 Volume 4 Issue 1 Pages 35-44
    Published: 1955
    Released on J-STAGE: May 26, 2009
    JOURNAL FREE ACCESS
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  • TATSUYA KUROKAWA
    1955 Volume 4 Issue 1 Pages 47-59
    Published: 1955
    Released on J-STAGE: May 26, 2009
    JOURNAL FREE ACCESS
    In this experimental study transplantation of urinary bladder epithelium according to Huggin's method was performed in 60 guinea pigs dividing the pigs in two groups, the experimental group and the control group. The experimental group was fed with vitamin C deficiency diet, while the control group was nutritioned with vitamin C added to this deficiency diet. The results obtained are as follows:
    Bone formations in the experimental group were very rare in comparison with that in the control group.
    Contrarily, in the experimental group the formations of hyalinized lesions with tendency to proliferation of elastic fibers were demonstrated, resembling the result obtained in Koide's experimental study transplanting the prostatic tissue and seminal vesicle epithelium subfascially.
    The hyalinized lesions were discussed dividing them into three types, namely, the first type, the second type and the third compound type.
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